The influence of an extra-articular implant on bone remodelling of the knee joint

Saeidi, Morteza; Gubaua, José Eduardo; Kelly, Piaras; Kazemi, Mousa; Besier, Thor F.; Dicati, Gabriela Wessling Oening; Pereira, Jucélio Tomás; Neitzert, Thomas; Ramezani, Maziar

doi:10.1007/s10237-019-01193-7

Cited by 10 publications

(7 citation statements)

References 44 publications

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“…These models have been numerically implemented in finite element analysis to evaluate their predictive capacity to simulate bone adaptation to mechanical loading (Huiskes et al 1987 ; Beaupré et al 1990a , b ; Weinans et al 1992 ; Mullender et al 1994 ; Adachi et al 2001 ; Ruimerman et al 2005 ; Fernández et al 2010 , 2012a ; Garzón-Alvarado et al 2012 ; Idhammad et al 2013 ; Garijo et al 2014 ; Mohaghegh et al 2014 ; Mauck et al 2016 ) and are reviewed elsewhere (Gerhard et al 2009 ; Webster and Muller 2011 ; Amirouche and Bobko 2015 ). The theories of bone adaptation that have been developed in the past decades to predict changes in bone shape and density are based on strain (Turner et al 1997 ; Wang et al 2016 ), stresses (Gong et al 2013 ), strain energy density (SED) (Huiskes et al 1987 ; Weinans et al 1992 ; Mullender et al 1994 ; Fernández et al 2010 , 2012a ; Garzón-Alvarado et al 2012 ; Saeidi et al 2020 ; Suárez et al 2012 ), deformations (Papathanasopoulou et al 2002 ), cell proliferation (Pivonka et al 2008 ) and mechanical damage (Prendergast and Taylor 1994 ; Garcia-Aznar et al 2005 ; Martínez et al 2006 ; Hambli et al 2011 ). Although there are many important aspects of bone remodelling, they are limited only to the study of bone response to a specific stimulus.…”

Section: Introductionmentioning

confidence: 99%

Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework

Bansod

Kebbach

Kluess

et al. 2021

Biomech Model Mechanobiol

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Bone tissue exhibits piezoelectric properties and thus is capable of transforming mechanical stress into electrical potential. Piezoelectricity has been shown to play a vital role in bone adaptation and remodelling processes. Therefore, to better understand the interplay between mechanical and electrical stimulation during these processes, strain-adaptive bone remodelling models without and with considering the piezoelectric effect were simulated using the Python-based open-source software framework. To discretise numerical attributes, the finite element method (FEM) was used for the spatial variables and an explicit Euler scheme for the temporal derivatives. The predicted bone apparent density distributions were qualitatively and quantitatively evaluated against the radiographic scan of a human proximal femur and the bone apparent density calculated using a bone mineral density (BMD) calibration phantom, respectively. Additionally, the effect of the initial bone density on the resulting predicted density distribution was investigated globally and locally. The simulation results showed that the electrically stimulated bone surface enhanced bone deposition and these are in good agreement with previous findings from the literature. Moreover, mechanical stimuli due to daily physical activities could be supported by therapeutic electrical stimulation to reduce bone loss in case of physical impairment or osteoporosis. The bone remodelling algorithm implemented using an open-source software framework facilitates easy accessibility and reproducibility of finite element analysis made.

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Section: Introductionmentioning

confidence: 99%

Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework

Bansod

Kebbach

Kluess

et al. 2021

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…The accuracy of the analysis depends on the authenticity of the models and the validity of the loading conditions. The current study reconstructed a heterogeneous femoral model which could realistically reflect the biomechanical performance of diverse bone densities ( Saeidi et al, 2020 ; Ghaziani et al, 2021 ). Meanwhile, the accuracy of the heterogeneous model reconstruction method in this study has been demonstrated by previous biomechanical tests ( Zhang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Zhang

Liu

Han

et al. 2022

Front. Bioeng. Biotechnol.

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Purpose: The management of bone defects is a crucial content of total knee revision. This study compared the biomechanical performance of porous Ti6Al4V block and tumor prosthesis UHMWPE block in treating distal femoral bone defects.Methods: The finite element models of AORI type 3 distal femoral bone defect treated with porous Ti6Al4V block and UHMWPE block were established. Sensitivity analysis was performed to obtain the appropriate mesh size. The biomechanical performance of treatment methods in bone defects were evaluated according to the peak stress, the Von Mises stress distribution, and the average stresses of regions of interest under the condition of standing on one foot and flexion of the knee. Statistical analysis was conducted by independent samples t-test in SPSS (p < 0.05).Results: In the standing on one-foot state, the peak stress of the porous Ti6Al4V block was 12.42 MPa and that of the UHMWPE block was 19.97 MPa, which is close to its yield stress (21 MPa). Meanwhile, the stress distribution of the UHMWPE block was uneven. In the flexion state, the peak stress of the porous Ti6Al4V block was 16.28 MPa, while that of the UHMWPE block was 14.82 MPa. Compared with the porous Ti6Al4V block group, the average stress of the region of interest in UHMWPE block group was higher in the standing on one foot state and lower in the flexion state (p < 0.05).Conclusion: More uniform stress distribution was identified in the porous Ti6Al4V block application which could reserve more bone. On the contrary, uneven stress distribution and a larger high-stress concentration area were found in the UHMWPE block. Hence, the porous Ti6Al4V block is recommended for the treatment of AORI type 3 distal femoral bone defect.

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“…In addition, since the theory of SED based bone remodelling approach 64,[125][126][127][128][129] came into existence, there has not been much significant development in the remodelling approaches. However, most of the models developed henceforth are mostly subtle need-based modifications 93,95,125,[130][131][132][133][134] of the existing formulation of Huiskes and co-workers 64,85 and the Stanford model 84,92,135 of bone adaptation.…”

Section: Studies On Internal Bone Remodelling and External Bone Remod...mentioning

confidence: 99%

Application of finite element analysis to tissue differentiation and bone remodelling approaches and their use in design optimization of orthopaedic implants: A review

Ghosh

Chanda

Chakraborty

2022

Numer Methods Biomed Eng

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Post-operative bone growth and long-term bone adaptation around the orthopaedic implants are simulated using the mechanoregulation based tissuedifferentiation and adaptive bone remodelling algorithms, respectively. The primary objective of these algorithms was to assess biomechanical feasibility and reliability of orthopaedic implants. This article aims to offer a comprehensive review of the developments in mathematical models of tissuedifferentiation and bone adaptation and their applications in studies involving design optimization of orthopaedic implants over three decades. Despite the different mechanoregulatory models developed, existing literature confirm that none of the models can be highly regarded or completely disregarded over each other. Not much development in mathematical formulations has been observed from the current state of knowledge due to the lack of in vivo studies involving clinically relevant animal models, which further retarded the development of such models to use in translational research at a fast pace. Future investigations involving artificial intelligence (AI), soft-computing techniques and combined tissue-differentiation and bone-adaptation studies involving animal subjects for model verification are needed to formulate more sophisticated mathematical models to enhance the accuracy of pre-clinical testing of orthopaedic implants.

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The influence of an extra-articular implant on bone remodelling of the knee joint

Cited by 10 publications

References 44 publications

Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework

Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Application of finite element analysis to tissue differentiation and bone remodelling approaches and their use in design optimization of orthopaedic implants: A review

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