The Influence of Anoxia on Lactate Utilization in Man after Prolonged Muscnlar Work

Abstract

Summary. A slight modification of Barker and Summerson's method of lactic acid determination is described. The rates of lactate utilization, urinary lactate excretion and blood glycolysis during recovery from prolonged muscular exercise were studied in two subjects working on a bicycle ergometer. The results indicate that under the specified conditions the rate of lactate utilization is not significantly altered by anoxia caused by inhalation of low percentage oxygen mixtures. the rate of blood glycolysis is low compared with the utilization rate of lactate and is independent of the blood lactate level. the rate of urinary lactate excretion is very low compared with the utilization rate of lactate. and is independent of anoxia. The difficulties in determining the chemical order of the lactate utilization processes are discussed.

Respiratory Regulation During Exercise in Unconditioned Subjects 1

“…The finding has been confirmed abundantly (20,22,27,32,33). Conversely, it is known that ventilation for a given work rate is greater at high altitudes (13,34,35) or while breathing low-oxygen mixtures (15,27,36,37) than it is at normal oxygen tensions. In the present study a trial was made of the effect on ventilation of changing from air to 15%o 02 mining "expected" ventilation and per cent oxygen saturation from the control periods was the same as described in the preceding section.…”

Plasma Catecholamines during Sustained Isometric Exercise

“…Blood lactate concentration was determined by Strom's modification of the Barker & Summerson method (Strom, 1949); the error of duplicate determinations in this laboratory was f0.14 mmol/l for concentrations between 0 and 3.3 mmol/l and f0.19 mmol/l for concentrations between 3.3 and 7.8 mmol/l (n = 50). …”

Alteration in Carboxyhemoglobin Concentrations During Exposure to 9 ppm Carbon Monoxide for 8 Hours at Sea Level and 2134 m Altitude in a Hypobaric Chamber

“…Blood lactates were determined by the Strom method. 10 The data were tested by four-factor analysis of variance with repeated measures across CO, PB, and time. When a significant F was observed, the Tukey procedure was used to determine which difference existed at p <0.05 level or better for rejection of the null hypothesis.…”