The influence of anticoagulant therapy on the occurrence of cardiac rupture and hemopericardium following heart infarction. II. A controlled study of a selected treated group based on 1,044 autopsies

Lange, Henrik F.; Aarseth, Sverre

doi:10.1016/0002-8703(58)90237-0

Cited by 24 publications

(5 citation statements)

References 6 publications

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“…I t is widely believed that treatment with anticoagulants increases the risk of rupture (1,14,16,28). Anticoagulants had been used in only 4 of our cases and only in one (No.…”

Section: Discussionmentioning

confidence: 99%

Perforation of the Interventricular Septum in Myocardial Infarction: A Study Based upon an Autopsy Material

Lundberg

Söderström

1962

Journal of Internal Medicine

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“…I t is widely believed that treatment with anticoagulants increases the risk of rupture (1,14,16,28). Anticoagulants had been used in only 4 of our cases and only in one (No.…”

Section: Discussionmentioning

confidence: 99%

Perforation of the Interventricular Septum in Myocardial Infarction: A Study Based upon an Autopsy Material

Lundberg

Söderström

1962

Journal of Internal Medicine

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“…Some authors have emphasized one or the other [7-13, 18, 19], or have used both to diagnose PER [37], As Spodick [38] has countered this leads to confusion since PE often accompa nies cardiac and systemic diseases other than MI. PE is associated with PER, myocardial rupture, anticoagula tion, thrombolysis, pericardial tamponade, hemopericardium or pericardial constriction [23][24][25][26][39][40][41][42][43][44][45][46]. In the absence of complications, interest is merely restricted to the natural course of PE as determined by serial echocar diography.…”

Section: Resultsmentioning

confidence: 99%

Pericarditis and Pericardial Effusion in Patients with Acute Myocardial Infarction

Madias¹,

Perdoncin²,

Bartoszyk³

et al. 1994

Am J Noninvas Cardiol

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A consecutive series of 174 patients with acute myocardial infarction (MI) was prospectively monitored for pericardial friction rub to diagnose pericarditis (PER) and had three echocardiograms on days 1, 3 and 10 of hospitalization, to detect a pericardial effusion (PE). The relationship of heparin therapy to PER and PE was also studied. Patients with PER (n = 41,23.6% of total) had a higher rate of anterior MI (65.9 vs. 36.8%, p < 0.001), heparin therapy (100 vs. 84.2%, p< 0.001) and PE (34.1 vs. 15.0%, p< 0.01) than those without PER; also the PE on day 1 was smaller in the patients with than without PER (0.5 ± 1.2 vs. 2.3 ± 2.7 mm, p < 0.005), but not different on days 3 and 10. Patients with PE (n = 34, 19.5% of total) differed from those without PE only in the incidence of PER (41 vs. 19%, p < 0.01). PE increased between days 1 and 3 (1.5 ± 2.3 vs. 3.7 ± 5.3 mm, p < 0.05), but was not different between days 3 and 10, during which it was 3.8 ± 3.3 mm. No higher rate of complications was noted in connection with PER or PE, either in the hospital or for a mean of 20 months after discharge. Heparin therapy in patients with PER and PE did not have an untoward effect. Hence, PER and PE were frequent in patients with MI; their emergence even in patients receiving heparin did not alter the expected clinical outcome, both in the hospital and during a mean 20-month follow-up after discharge.

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“…More than 40 years ago, an autopsy study in Scandinavia looked at the difference in outcomes between patients who received anticoagulants after myocardial infarction and those who did not. 1 The study found a higher incidence of myocardial rupture and hemopericardia in the pa-tients who received anticoagulants, but the difference was not statistically significant. On the basis of that study, one could argue that there may be some increased risk in giving anticoagulants to patients who have pericarditis.…”

mentioning

confidence: 79%

Decision Making by Analogy

Greenberg

Root

1995

N Engl J Med

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In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows.A 27-year-old woman with a history of seizures since childhood was brought to the emergency department because of sharp left anterior pleuritic chest pain, a productive cough, increasingly severe shortness of breath, nausea, and one episode of vomiting. She had no fever, chills, sweats, diarrhea, dysuria, edema, orthopnea, or weight change. She had been ill only one day. The New England Journal of Medicine Downloaded from nejm.org at PRINCETON UNIVERSITY on August 11, 2015. For personal use only. No other uses without permission.

show abstract

The influence of anticoagulant therapy on the occurrence of cardiac rupture and hemopericardium following heart infarction. II. A controlled study of a selected treated group based on 1,044 autopsies

Cited by 24 publications

References 6 publications

Perforation of the Interventricular Septum in Myocardial Infarction: A Study Based upon an Autopsy Material

Perforation of the Interventricular Septum in Myocardial Infarction: A Study Based upon an Autopsy Material

Pericarditis and Pericardial Effusion in Patients with Acute Myocardial Infarction

Decision Making by Analogy

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