The influence of body mass index on skin susceptibility to sodium lauryl sulphate

Löffler, Harald; Aramaki, J; Effendy, Isaak

doi:10.1046/j.0909-752x

Cited by 107 publications

(116 citation statements)

References 30 publications

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“…TEWL is normally elevated in obese subjects [75] and the inferior barrier possibly leading to enhanced secretion of serine proteases could contribute to activating the PAR-2 system and skin pigmentation problem.…”

Section: Racial Differences In Photoagingmentioning

confidence: 99%

Ethnic skin types: are there differences in skin structure and function?¹

Rawlings¹

2006

Intern J of Cosmetic Sci

323

277

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SynopsisPeople of skin of colour comprise the majority of the world's population and Asian subjects comprise more than half of the total population of the earth. Even so, the literature on the characteristics of the subjects with skin of colour is limited. Several groups over the past decades have attempted to decipher the underlying differences in skin structure and function in different ethnic skin types. However, most of these studies have been of small scale and in some studies interindividual differences in skin quality overwhelm any racial differences. There has been a recent call for more studies to address genetic together with phenotypic differences among different racial groups and in this respect several large-scale studies have been conducted recently. The most obvious ethnic skin difference relates to skin colour which is dominated by the presence of melanin. The photoprotection derived from this polymer influences the rate of the skin aging changes between the different racial groups. However, all racial groups are eventually subjected to the photoaging process. Generally Caucasians have an earlier onset and greater skin wrinkling and sagging signs than other skin types and in general increased pigmentary problems are seen in skin of colour although one large study reported that East Asians living in the U.S.A. had the least pigment spots. Induction of a hyperpigmentary response is thought to be through signaling by the protease-activated receptor-2 which together with its activating protease is increased in the epidermis of subjects with skin of colour. Changes in skin biophysical properties with age demonstrate that the more darkly pigmented subjects retaining younger skin properties compared with the more lightly pigmented groups. However, despite having a more compact stratum corneum (SC) there are conflicting reports on barrier function in these subjects. Nevertheless, upon a chemical or mechanical challenge the SC barrier function is reported to be stronger in subjects with darker skin despite having the reported lowest ceramide levels. One has to remember that barrier function relates to the total architecture of the SC and not just its lipid levels. Asian skin is reported to possess a similar basal transepidermal water loss (TEWL) to Caucasian skin and similar ceramide levels but upon mechanical challenge it has the weakest barrier function. Differences in intercellular cohesion are obviously apparent. In contrast reduced SC natural moisturizing factor levels have been reported compared with Caucasian and African American skin. These differences will contribute to differences in desquamation but few data are available. One recent study has shown reduced epidermal Cathepsin L2 levels in darker skin types which if also occurs in the SC could contribute to the known skin ashing problems these subjects experience. In very general terms as the desquamatory enzymes are extruded with the lamellar granules subjects with lowered SC lipid levels are expected to have lowered desquamatory enzyme levels...

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Section: Racial Differences In Photoagingmentioning

confidence: 99%

Ethnic skin types: are there differences in skin structure and function?¹

Rawlings¹

2006

Intern J of Cosmetic Sci

323

277

View full text Add to dashboard Cite

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“…Obese individuals demonstrated significantly increased transepidermal water loss compared with control subjects 29 . It was reported that morbidly obese patients have dry skin and impaired skin barrier repair 1 .…”

Section: Resultsmentioning

confidence: 99%

Erişkin Obez Hastalarda Dermatolojik Bulgular

Demirci¹,

Bilen²,

Aktürk³

et al. 2016

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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Objectives: There are only a few studies about the dermatological findings of obese patients in the literature. However, we aimed to investigate the dermatological findings of obese patients and the relationship of these conditions with age, menopause, number of pregnancies, and insulin resistance in our study. Material and Methods:This study included 119 patients with a body mass index higher than 30 kg/m 2 and 122 normal weight individuals as a control group. Also, the insulin resistance was calculated of the patients. The prevalences of dermatoses were compared between the two groups. Results:The most common dermatologic finding in both groups was striae. But, there was not statistically significant difference between two groups. Plantar hyperkeratosis was found in 47.1% and 7.4% of patients in the study and control groups, respectively and the difference was statistically significant. Also the frequencies of acrochordon, acanthosis nigricans, keratosis pilaris and intertrigo were significantly higher in the obese group. Varicose veins were more common in the control group (36.9%) compared with the obese group (31.9%). There was no statistically significant difference between the patients with and without insulin resistance in terms of frequency of plantar hyperkeratosis, intertrigo, keratosis pilaris, varicose veins, striae, acrochordon and xerosis in the obese group. However, it was striking that there was insulin resistance in 13 of the 14 patients who had acanthosis nigricans. Conclusions:Our study showed that some dermatological findings were significantly more common in obese patients. So, prevention of obesity is important in terms of prevention of these dermatoses. Key words: Obesity, skin manifestations, insulin resistanceAmaç: Obez hastalardaki dermatolojik bulgularla ilişkili olarak literatürde çok az sayıda çalışma bulunmaktadır. Bu nedenle çalışmamızda obez hastalardaki deri bulgularını ve bunların yaş, menapoz, gebelik sayısı ve insülin direnci ile ilişkilerinin araştırması amaçlanmıştır. Gereç ve Yöntemler:Bu çalışma vücut kitle indeksi 30 kg/m 2 nin üzerinde olan 119 hastayı ve kontrol grubu olarak normal kiloya sahip 122 bireyi kapsamaktadır. Dematozların görülme sıklıkları iki grup arasında karşılaştırılmıştır. Bulgular:Her iki grupta da en sık rastlanan dermatolojik bulgu stria idi. Ancak iki grup arasında istatistiksel anlamlı bir farklılık yoktu. Plantar hiperkeratoz çalışma ve kontrol gruplarında sırasıyla % 47,1 ve % 7,4 oranlarında bulundu ve farklılık istatistiksel olarak anlamlıydı. Aynı zamanda akrokordon, akantozis nigrikans, keratozis pilaris ve intertrigo sıklığı obez grupta anlamlı olarak yüksekti. Variköz venler kontrol grubunda (% 36,9) obez grup (% 31,9) ile karşılaştırıldığında daha sık gözlendi. Çalışma grubunda insülin direnci olan ve olmayan olgular plantar hiperkeratoz, intertrigo, keratozis pilaris, variköz venler, stria, akrokordon ve kserosis görülme sıklıklarına göre karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık yoktu. Ancak akantozis nigrikans olan...

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“…Obesity is a key cause of the failure of capillary microvessel function, which in turn is related to changes in microvessels and high blood pressure [15]. Loffler et al [16] illustrated that the circulation in the skin was elevated in those with a high BMI, but the speed of cells within the blood vessel becomes very slow. These facts support the view that obesity negatively influences wound healing.…”

Section: Discussionmentioning

confidence: 99%

Review of Keloid Patients with Clinical Experience

Joh

Shin

Park

et al. 2014

Arch Aesthetic Plast Surg

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Background Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood. Despite many studies of the pathogenesis and cause, little is known of the predisposing factors or the diathesis. Therefore, we evaluated patients with keloid for 13 years clinical experience, with the goal of considering the causative factors and physical disposition of keloid. Methods We evaluated 107 patients (38 males, 69 females; median age 22.31 years, range 7-58 years) who visited the department of plastic and reconstructive surgery from March 1998 to December 2010. The patients' chart and clinical photo were reviewed for the study. Results Etiologies were an intended wound like piercing or surgical wound (n =39), avulsion flap injury (n=30), laceration (n=29) and burn (n=9). The location were the head and neck (n=38), trunk (n=23), upper extremity (n=21), lower extremity (n=16) and face (n =9). Patients with more than overweight (>23 kg/m 2 , Body mass index) were 84 in 107 patients (78.5%) with keloids. Conclusions In the care of the keloids, patient information, particularly sex, age and body mass index, it may be useful indicators for expecting prognosis of the patients and treating with proper management. Particularly, large-scale accurate follow-up observations on obese patients will be critical.

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The influence of body mass index on skin susceptibility to sodium lauryl sulphate

Cited by 107 publications

References 30 publications

Ethnic skin types: are there differences in skin structure and function?¹

Ethnic skin types: are there differences in skin structure and function?¹

Erişkin Obez Hastalarda Dermatolojik Bulgular

Review of Keloid Patients with Clinical Experience

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The influence of body mass index on skin susceptibility to sodium lauryl sulphate

Cited by 107 publications

References 30 publications

Ethnic skin types: are there differences in skin structure and function?1

Ethnic skin types: are there differences in skin structure and function?1

Erişkin Obez Hastalarda Dermatolojik Bulgular

Review of Keloid Patients with Clinical Experience

Contact Info

Product

Resources

About

Ethnic skin types: are there differences in skin structure and function?¹

Ethnic skin types: are there differences in skin structure and function?¹