The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

García-Soriano, David; Amaro, Rebeca; Lafuente-Gómez, Nuria; Milán-Rois, Paula; Somoza, Álvaro; Navío, Cristina; Herranz, Fernando; Gutiérrez, Lucía; Salas, Gorka

doi:10.1016/j.jcis.2020.06.011

Cited by 26 publications

(26 citation statements)

References 54 publications

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“…Hence, using smart nanoparticles could overcome the shortcomings of traditional chemotherapy, such as the lack of specificity and side effects [8,9]. In this sense, magnetic nanoparticles have been widely studied [10][11][12][13]. They can be used as a diagnostic tool in magnetic resonance imaging (MRI), promote cancer cell death via magnetic hyperthermia (MH), which involves the generation of heat when an alternating magnetic field (AMF) is applied [10,[14][15][16], and also as carriers of anticancer drugs [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties

Lafuente-Gómez

Milán-Rois

García-Soriano

et al. 2021

Cancers

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Magnetic nanoparticles (MNP) are employed as nanocarriers and in magnetic hyperthermia (MH) for the treatment of cancers. Herein, a smart drug delivery system composed of MNP functionalized with the cytotoxic drug gemcitabine (MNP-GEM) has been thoroughly evaluated. The linker employed is based on a disulfide bond and allows the controlled release of GEM under a highly reducing environment, which is frequently present in the cytoplasm of tumor cells. The stability, MH, and the interaction with plasma proteins of the nanoparticles are evaluated, highlighting their great potential for biological applications. Their cytotoxicity is assessed in three pancreatic cancer cell lines with different sensitivity to GEM, including the generation of reactive oxygen species (ROS), the effects on the cell cycle, and the mechanisms of cell death involved. Remarkably, the proposed nanocarrier is better internalized than unmodified nanoparticles, and it is particularly effective in PANC-1 cells, resistant to GEM, but not in non-tumoral keratinocytes. Additionally, its combination with MH produces a synergistic cytotoxic effect in all cancer cell lines tested. In conclusion, MNP-GEM presents a promising potential for treating pancreatic cancer, due to multiple parameters, such as reduced binding to plasma proteins, increased internalization, and synergistic activity when combined with MH.

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Section: Introductionmentioning

confidence: 99%

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties

Lafuente-Gómez

Milán-Rois

García-Soriano

et al. 2021

Cancers

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“…For example, magnets can be used to guide nano-drugs to interested tissues, thus, significantly improving the selectivity. For this method, magnetic nanoparticles based on iron oxide are usually used because of their stability and biocompatibility in biomedical applications [ 303 , 304 ]. Interestingly, they can combine with liposomes, polymers, and porous metal nanocapsules to make them magnetic.…”

Section: Stimuli-responsive Nanomaterials For Lymphatic System Drug D...mentioning

confidence: 99%

Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes

et al. 2022

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The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, and immune regulation. The lymph nodes (LNs) are known as the primary sites of tumor metastasis and the metastatic LNs largely affected the prognosis of the patiens. A well-designed lymphatic-targeted system favors disease treatment as well as vaccination efficacy. In recent years, development of nanotechnologies and emerging biomaterials have gained increasing attention in developing lymph-node-targeted drug-delivery systems. By mimicking the endogenous macromolecules or lipid conjugates, lymph-node-targeted nanocarries hold potential for disease diagnosis and tumor therapy. This review gives an introduction to the physiological functions of LNs and the roles of LNs in diseases, followed by a review of typical lymph-node-targeted nanomaterial-based drug-delivery systems (e.g., liposomes, micelles, inorganic nanomaterials, hydrogel, and nanocapsules). Future perspectives and conclusions concerned with lymph-node-targeted drug-delivery systems are also provided.

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“…[1][2][3] A wide variety of nanoparticles have been developed for biomedical purposes for years. [4][5][6][7] In this sense, magnetic nanoparticles, composed of metals and/or oxide metals, can be easily synthesized with inexpensive procedures suitable for large-scale production, 8 their magnetic properties have been explored for diagnostic and therapeutic purposes, [9][10][11][12] and they have been studied for controlled drug release applications. [13][14][15][16] Interestingly, they also display self-adjuvating properties that can be exploited to promote further or modulate the immune function.…”

Section: Introductionmentioning

confidence: 99%

Synergistic immunomodulatory effect in macrophages mediated by magnetic nanoparticles modified with miRNAs

et al. 2022

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The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

Cited by 26 publications

References 54 publications

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties

Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes

Synergistic immunomodulatory effect in macrophages mediated by magnetic nanoparticles modified with miRNAs

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