The influence of chain length of a competitive polyanion and nature of monovalent counterions on the direction of the substitution reaction of polyelectrolyte complexes

Izumrudov, Vladimir A.; Bronich, Tatiana K.; Saburova, O.; Zezin, A. B.; Kabanov, V.A.

doi:10.1002/marc.1988.030090102

Cited by 54 publications

(35 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our result correlates well with data obtained by Schindler et al 12) , where the decrease of cation ability to destroy DNA-containing PEC in the order Ca ++ F Sr ++ S Li + A Na + F K + A Cs + has been ascertained. The same interrelation between the ability of cations and anions to destroy PEC and their affinity as counterions to the components of PEC was established for (PMA-PEVP) 6) and (PPh-PEVP) 25) complexes. The data obtained imply that the stability of DNA-containing PEC could be controlled effectively by changing the length, charge, and structure of the polycation chain 4 NCl is presented by a dotted line.…”

Section: Resultsmentioning

confidence: 99%

“…Data obtained in this paper could be important for the prediction and precise control of the equilibrium of the competitive reactions in solutions of DNA-containing PEC. The potential of such an approach for the control of reactions was demonstrated in a study of the model system (PMA-PEVP-PPh) 25) . values of PEC(DNA-PAVP) were calculated from data presented in Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stability of DNA-containing interpolyelectrolyte complexes in water-salt solutions

Izumrudov¹,

Zhiryakova

1999

Macromol. Chem. Phys.

Self Cite

View full text Add to dashboard Cite

SUMMARY: Destruction of interpolyelectrolyte complexes (PEC) formed by DNA and different poly cations was achieved by addition of low molecular weight electrolytes. Monitoring of PEC dissociation was carried out by fluorescence quenching using the ability of the cationic dye ethidium bromide to intercalate into free sites of the DNA double helix accompanied by fluorescence. Degree of polymerization and charge density of the polycations as well as their N-alkyl substituentes (alkyl = methyl, ethyl, and propyl) were shown to be factors influencing the stability of PEC. The ability of added cations and anions to dissociate PEC decreases in the order Cawhich coincides with a decrease of affinity of the same counterions to DNA and to the polycation. The data obtained indicate that the change of the stability of DNA-containing PEC shows the same regularities as revealed for the stability of interpolyelectrolyte complexes formed by oppositely charged flexible synthetic polyelectrolytes in water-salt solutions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stability of DNA-containing interpolyelectrolyte complexes in water-salt solutions

Izumrudov¹,

Zhiryakova

1999

Macromol. Chem. Phys.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The latter is deduced from the higher stability of PEC formed by PEVP of different chain lengths with the polyphosphate anion, as compared to the corresponding PMA-containing PEC. [11] In contrast to PEC formed by flexible synthetic PMA and polyphosphate, the DNAcontaining PEC with short PEVP ceased to obey this regularity. It supports the assumption of the important role of charge-charge conformity of the partners in the dissociation of DNA-containing PEC with relatively short polyamines.…”

Section: Resultsmentioning

confidence: 99%

Polyelectrolyte Complexes Formed by Calf Thymus DNA and Aliphatic Ionenes: Unexpected Change in Stability upon Variation of Chain Length of Ionenes of Different Charge Density

Zelikin

Izumrudov

2002

Macromol. Biosci.

Self Cite

View full text Add to dashboard Cite

“…Analyses of the MD were performed on dried samples purified using an ultrafiltration apparatus (Filtron, cut off membrane 5 000 D) followed by lyophilization. The degree of carboxymethylation was determined on dried aliquots (15 -25 mg) by acidimetric titrations in a water/acetone mixture (1 : 1 v : v) acidified with 10 mol-% HNO 3 . The proportion of benzylamide, sulfonate, and sulfate groups was assessed from N and S elemental analysis performed by CNRS (France, Gif/Yvette).…”

Section: Methodsmentioning

confidence: 99%

“…In the present paper we report the results of a study of IPR which occured in the presence of modified dextrans (MD) with COO -, SO 3 -, and SO 4 -groups in the chains (Scheme 1). The MD were either labeled with the fluorescent pyrenyl group or not.…”

Section: Introductionmentioning

confidence: 98%

Interpolyelectrolyte reactions in solutions of functionalized dextrans with negatively charged groups along the chains

Izumrudov

Chaubet²,

Clairbois

et al. 1999

Macromol. Chem. Phys.

Self Cite

View full text Add to dashboard Cite

SUMMARY: Poly(methacrylate) and functionalized dextrans (obtained by random substitution of soluble dextran with carboxylate, benzylamide, sulfate, and sulfonate groups) were labeled with fluorescent pyrenyl groups. The formation of polyelectrolyte complexes (PEC) of both labeled polyanions with poly(N-ethyl-4-vinylpyridinium) as a quencher, and the competitive reactions in solutions of the PEC were studied by means of the fluorescence quenching technique. A complete excitation of fluorescence was observed when highly sulfated or sulfonated polyanion competitors like heparin and poly(styrenesulfonate) were added to the PEC solutions. We presume that a transfer of the polycation chains from PEC to the polyanion competitors occurs. Modified dextrans are good polyanion competitors due to their content of sulfate and sulfonate groups, even in small amounts. Moreover, the affinity of carboxylate groups containing polyanion competitors to the polycation increases according to the increasing charge density of the chains. Shielding of negative charges of the polyanions by addition of low-molecular weight counterions decreases the efficiency. The data obtained show that both chemical nature of the negatively charged groups and charge density of the polyanion chains are factors that effectively control the equilibrium of competitive interpolyelectrolyte reactions.

show abstract

The influence of chain length of a competitive polyanion and nature of monovalent counterions on the direction of the substitution reaction of polyelectrolyte complexes

Cited by 54 publications

References 2 publications

Stability of DNA-containing interpolyelectrolyte complexes in water-salt solutions

Stability of DNA-containing interpolyelectrolyte complexes in water-salt solutions

Polyelectrolyte Complexes Formed by Calf Thymus DNA and Aliphatic Ionenes: Unexpected Change in Stability upon Variation of Chain Length of Ionenes of Different Charge Density

Interpolyelectrolyte reactions in solutions of functionalized dextrans with negatively charged groups along the chains

Contact Info

Product

Resources

About