The Influence of Chain Microstructure of Biodegradable Copolyesters Obtained with Low-Toxic Zirconium Initiator to<i>In Vitro</i>Biocompatibility

Orchel, Arkadiusz; Jelonek, Katarzyna; Kasperczyk, Janusz; Dobrzyński, P.; Marcinkowski, Andrzej; Pamuła, Elżbieta; Orchel, Joanna; Bielecki, Ireneusz; Kulczycka, Anna

doi:10.1155/2013/176946

Cited by 24 publications

(22 citation statements)

References 51 publications

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“…Depending on the preparation process and physicochemical properties of drug molecules and the carrier, the drug can be either encapsulated into the carrier or adsorbed onto its surface. 38 If the encapsulated substance is fat-soluble, a simple emulsion method is usually used. A polymer and a drug are dissolved in a volatile water-immiscible organic solvent, as a rule, in methylene chloride or ethyl acetate.…”

Section: Ii2 Receptor Portrait Of a Cell As A Basis For Developing mentioning

confidence: 99%

New approaches to targeted drug delivery to tumour cells

Severin¹

2015

Russ. Chem. Rev.

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Section: Ii2 Receptor Portrait Of a Cell As A Basis For Developing mentioning

confidence: 99%

New approaches to targeted drug delivery to tumour cells

Severin¹

2015

Russ. Chem. Rev.

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“…Previous studies on the impact of polymer coatings on the corrosion resistance of a metal substrate, mainly non-biodegradable coatings, have been performed [23,27,28]. However, there have been a limited number of reports on the impact of biodegradable coatings on the corrosion resistance of metal substrates and their cytotoxicities [18,19,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

et al. 2020

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The inhibition of the corrosion of metal implants is still a challenge. This study aimed to increase the corrosion resistance of Ti6Al7Nb alloy implants through surface modification, including grinding, sandblasting, and anodic oxidation followed by the deposition of a polymer coating. The aim of the work was to determine the influence of biodegradable polymer coatings on the physico-chemical properties of a Ti6Al7Nb alloy used for short-term implants. Biodegradable coatings prepared from poly(glycolide-caprolactone) (P(GCap)), poly(glycolide ε-caprolactone-lactide) (P(GCapL)), and poly(lactide-glycolide) (PLGA) were applied in the studies. The dip-coating method with three cycles of dipping was applied. Corrosion resistance was assessed on the basis of potentiodynamic studies. The studies were carried out on samples after 30, 60, and 90 days of exposure to Ringer's solution. Surface topography, wettability, and cytotoxicity studies were also carried out. The degradation process of the base material was evaluated on the basis of the mass density of the metal ions released to the solution. The results indicated the influence of the coating type on corrosion resistance. In addition, a beneficial effect of the polymer coating on the reduction of the density of the released metal ions was found, as compared to the samples without polymer coatings. The obtained results provide basic knowledge for the development of polymer coatings enriched with an active substance. The presence of ciprofloxacin in the coating did not reduce the corrosion resistance of the metal substrate. Moreover, the cytotoxicity test using the extract dilution method demonstrated that the implants' coatings are promising for further in vitro and in vivo studies.The extensive use of biodegradable polymers in medical applications is mainly associated with the possibility of tailoring their physicochemical and mechanical properties. Controlled polymer degradation allows for their use as carriers of medicinal substances, ensuring drug release with regulated dynamics to obtain the expected therapeutic effects [5]. The mentioned group of biopolymers is characterized by an appropriate biocompatibility [4], and the achieved degradation products-mainly lactic, glycolic, and hydroxyhexanoic acids-are found to be neutral to the human organism and are metabolized in accordance the Krebs cycle [6]. The basic limitation of the use of biodegradable polymers relates to the mechanical properties that change over time. This feature may be disadvantageous in some applications, e.g., orthopedic implants. Treatment disorders can be observed as the implant weakens due to degradation processes. This can lead to repeated injuries. The consequence of this is the need to perform a revision surgery combined with the removal of an incompletely degraded and mechanically weakened implant and followed by its replacement with a new one. The revision surgery due to the progressive degradation of the polymer material may be associated with serious difficulties that lead to a much ...

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“…There are few reports on the influence of biodegradable coatings on the corrosion resistance of metal substrates [11,18,19].…”

Section: Introductionmentioning

confidence: 99%

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Kajzer¹,

Jaworska²,

Jelonek³

et al. 2018

Eksploatacja i Niezawodność – Maintenance and Reliability

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The aim of this study was to determine the influence of long-term exposure of Ringer’s solution on degradation of the anodically oxidated Ti6Al4V alloy coated with a biodegradable polymer coating. Polymeric coatings made of poly(glycolide-ε-caprolactone) – G-Cap and poly(glycolide- ε-caprolactone-lactide) – G-Cap-L were applied by a dip-coating method. Degradation was assessed on the basis of the results of pitting corrosion resistance and density of metal ions infiltrating to the solution. Studies were conducted for samples after 3, 6, 8, 10 and 12 weeks of exposure to the corrosive environment. In addition, topography of the surface of the polymer coating was assessed. As a result of potentiodynamic studies, the value of the polarization resistance and corrosion potential for the G-Cap and G-Cap-L coated samples were significantly decreased while simultaneous reduction of the density of metal ions infiltrating to the solution throughout the whole study period. There was also observed a faster degradation of the G-Cap coating compared to G-Cap-L, which showed local discontinuity after 12 weeks of exposure. The obtained results provide the basis for the development of polymeric coatings on surface of metal implants with predictable time / kinetics of degradation by selecting the composition of polymers while simultaneous limitation of metal ions infiltration into surrounding tissues.

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The Influence of Chain Microstructure of Biodegradable Copolyesters Obtained with Low-Toxic Zirconium Initiator toIn VitroBiocompatibility

Cited by 24 publications

References 51 publications

New approaches to targeted drug delivery to tumour cells

New approaches to targeted drug delivery to tumour cells

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

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