The Influence of Chitosan Concentration on Polyelectrolytes Complexes (PECs) of Chitosan – Poly-2-Acrylamido-2-Methylprophane Sulfonic Acid (PAMPS) as Potential Drug Carrier in Pulmonary Delivery Application

Wibowo, Arie; Mumtaziah,; Rachmawati, Systi Adi; Qulub, Fitriyatul; Asri, Lia Amelia Tresna Wulan; Aimon, Akfiny Hasdi; Suratman, Rochim

doi:10.1088/1757-899x/547/1/012028

Cited by 3 publications

(1 citation statement)

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“…However, they used multiple steps of the polymer-monomer pair reaction system to form their PECs. In our previous work, chitosan-PAMPS based PECs has successfully prepared by simple mixing of PAMPS solution and chitosan solution in sodium chloride (NaCl) (Wibowo et al, 2018;Wibowo et al, 2019). This method offers a simpler and faster strategy for obtaining chitosan-PAMPS-based PECs as they can be prepared directly from their polymer solution.…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Polyelectrolyte Complex Nanoparticles Based on Chitosan – Poly-2-Acrylamido-2-Methylpropane Sulfonic Acid as a Potential Drug Carrier Material

Wibowo¹,

Jatmiko²,

Ananda³

et al. 2021

IJTech

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Polyelectrolyte complexes (PECs) are attractive materials for drug delivery application as they offer simple preparations and high drug-loading efficiency. In this study, a novel method for preparing polyelectrolyte complex nanoparticles using a simple mixing method of chitosan and poly-2-acrylamido-2-methylpropane sulfonic acid (PAMPS) solutions is presented. The effect of chitosan concentrations was examined by fixing the PAMPS concentration at 0.01 %w/v, while chitosan concentrations were varied from 0.01 to 0.05 %w/v. Based on dynamic light scattering (DLS) and zeta sizer results, increasing the chitosan concentration led to increased average PEC particle sizes with broader particle distributions from 249.1 (polydispersity index/PDI 0.13) to 318.2 nm (PDI 0.19) and changed the particle surface charges from -5.85±0.34 to 11.95±0.84 mV. The addition of glutaraldehyde (GA) followed by dialysis eliminated sodium chloride (NaCl) and produced spherical PEC nanoparticles, confirmed via scanning electron microscopy (SEM) results. Among those samples, PECs with a chitosan concentration of 0.01 %w/v are the most promising drug carrier materials due to their negative surface charges, which promote prolonged circulation time in the bloodstream.

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Section: Introductionmentioning

confidence: 99%