The influence of chronic stress imposed on pregnant rats on the induced bone loss in their adult offspring

Semenoff-Segundo, Alex; Semenoff, Tereza Aparecida Delle Vedove; Borges, Álvaro Henrique; Pedro, Fábio Luís Miranda; Caporossi, Leonardo Stephan; Bosco, Álvaro Francisco

doi:10.1016/j.archoralbio.2011.10.018

Cited by 3 publications

(3 citation statements)

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“…There have been several studies reported in the literature corroborating these results. 13,[16][17][18] Stress causes a depression of various defense systems due to alteration of the central nervous system. The organism response is variable and depends on the type of stress imposed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Stress on Ligature-induced Periodontitis in Inbred and Noninbred Rats: A Radiographic Study

Semenoff-Segundo¹,

Borges²,

Bandéca³

et al. 2014

The Journal of Contemporary Dental Practice

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Section: Discussionmentioning

confidence: 99%

Effect of Chronic Stress on Ligature-induced Periodontitis in Inbred and Noninbred Rats: A Radiographic Study

Semenoff-Segundo¹,

Borges²,

Bandéca³

et al. 2014

The Journal of Contemporary Dental Practice

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“…A pesar de que el hueso posee esta capacidad intrínseca de reparación, existen factores que podrían modificarla hasta deteriorarla o hacerla insuficiente, como son los factores hormonales (cortisol y adrenalina) (6) y las modificaciones sobre los ejes inmuno-endocrinos. (7,8) Diversos estudios en humanos y en animales de experimentación nos indican una relación entre el estrés, principalmente el crónico, y el grado de pérdida ósea (9,10) . Existen modelos preclínicos con ratones seniles que relacionan al estrés crónico con la aceleración en el desarrollo de osteoporosis (11) ; sin embargo sería importante determinar cuál sería la función que ejerce el estrés agudo sobre los cambios moleculares que podrían afectar los procesos de reparación ósea ante una lesión, así como también es pertinente conocer cómo dichos procesos generados en el estrés agudo son la base para el desarrollo del estrés crónico y sus cambios neuroinmunoendocrinos.…”

Section: Introductionunclassified

Estrés agudo y crónico en la reparación ósea: un enfoque actualizado desde las Neurociencias.

Ruiz-Ramírez

Becerra-Bravo

Lam-Figueroa

2022

Rev. chil. neuro-psiquiatr.

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The physiological molecular mechanisms associated with the response to acute and chronic stress allow us to understand the changes that these can produce in the various tissues of the body. Various investigations highlight the role of chronic stress in the development of dysfunctions that affect body balance; However, it must be considered that the mechanisms related to acute stress can also influence the development of pathologies and the progression of the deleterious manifestations of chronic stress. On the other hand, one of the most studied tissues in recent years has been bone tissue, since it is influenced by nervous, endocrine and immunological factors. This paper seeks to analyze the neuroscientific bases of the molecular mechanisms of stress and their relationship in the bone repair process. Therefore, a literature search was carried out in the Pubmed, Scopus and ScienceDirect databases. Concluding that stress modifies the release of neurotransmitters, the action of the autonomic nervous system, the release of corticotropic hormones and the activity of various cytokines; which leads to the imbalance of the regulation and repair processes of the bone tissue subjected to load or injury.

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“…show that the chemical modulation of the HPA axis, or directly the effect of physical chronic stress during pregnancy are responsible for a higher progression of periodontitis induced in adulthood 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Effect of chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood

et al. 2013

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PURPOSE:To investigate the effect chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood. METHODS:Ten couples of adult Wistar rats were selected for mating. After birth, the female and their respective offsprings were allocated into two groups. Ligature Group (LG): offsprings were only watched during breast-feeding; Stress-ligature Group (SLG): after 24h of live birth, the offsprings were moved away from their mothers every day for four hours during breast-feeding for 20 days; in both approaches, after reaching ± 250g, ten rats were included in the groups. Periodontal disease was induced by a silk suture placed around the maxillary right second molar. The left side was used as control. After 15 days, the animals were subjected to euthanasia, maxillary bones were removed and stored in 10% formaldehyde. After 48h, radiographs were taken and revealed and were used for bone destruction analysis. Examiner was blind and calibrated for measurements. RESULTS:Stress-ligature group presented higher bone loss values in relation to ligature group (p<0.05). CONCLUSION:Exposure to chronic stress imposed on offsprings produced a greater progression of bone loss induced during adulthood.

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The influence of chronic stress imposed on pregnant rats on the induced bone loss in their adult offspring

Cited by 3 publications

References 46 publications

Effect of Chronic Stress on Ligature-induced Periodontitis in Inbred and Noninbred Rats: A Radiographic Study

Effect of Chronic Stress on Ligature-induced Periodontitis in Inbred and Noninbred Rats: A Radiographic Study

Estrés agudo y crónico en la reparación ósea: un enfoque actualizado desde las Neurociencias.

Effect of chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood

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