The influence of circular RNAs on autophagy and disease progression

Wang, Yian; Mo, Yongzhen; Miao, Peng; Zhang, Shanshan; Gong, Zhaojian; Yan, Qijia; Tang, Yue; He, Yi; Liao, Qianjin; Li, Xiayu; Wu, Xu; Xiang, Bo; Zhou, Ming; Li, Yong; Li, Guiyuan; Li, Xiaoling; Zeng, Zhaoyang; Guo, Can

doi:10.1080/15548627.2021.1917131

Cited by 60 publications

(37 citation statements)

References 154 publications

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“…Meanwhile, autophagy widely existed in almost all eukaryotes, playing essential roles in the material homeostasis in cancer cells ( Chang et al, 2021 ; Kitada and Koya, 2021 ). A growing number of articles demonstrate the associations between these two processes, which may break a novel research ground ( Zhou et al, 2021a ; Wang et al, 2021b ).…”

Section: Discussionmentioning

confidence: 99%

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Circular RNA-regulated autophagy is involved in cancer progression

Zhou

Lin

Wang

et al. 2022

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a sort of long, non-coding RNA molecules with a covalently closed continuous ring structure without 5'-3' polarity and poly-A tail. The modulative role of circRNAs in malignant diseases has been elucidated by many studies in recent years via bioinformatics and high-throughput sequencing technologies. Generally, circRNA affects the proliferative, invasive, and migrative capacity of malignant cells via various mechanisms, exhibiting great potential as novel biomarkers in the diagnoses or treatments of malignancies. Meanwhile, autophagy preserves cellular homeostasis, serving as a vital molecular process in tumor progression. Mounting studies have demonstrated that autophagy can not only contribute to cancer cell survival but can also induce autophagic cell death in specific conditions. A growing number of research studies have indicated that there existed abundant associations between circRNAs and autophagy. Herein, we systemically reviewed and discussed recent studies on this topic in different malignancies and concluded that the circRNA–autophagy axis played crucial roles in the proliferation, metastasis, invasion, and drug or radiation resistance of different tumor cells.

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Section: Discussionmentioning

confidence: 99%

“…Longev. 2021, 9936154. doi:10.1155 Zhu, Y., Huang, S., Chen, S., Chen, J., Wang, Z., Wang, Y., et al (2021). SOX2 promotes chemoresistance, cancer stem cells properties, and epithelialmesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer.…”

Section: Author Contributionsmentioning

confidence: 99%

Circular RNA-regulated autophagy is involved in cancer progression

Zhou

Lin

Wang

et al. 2022

Front. Cell Dev. Biol.

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“…When autophagy is initiated, cells undergo morphological changes, including the formation of double-membraned autophagosomes and fusion with lysosomes as autolysosomes to drive the suicide process (Y. Wang, Mo, et al, 2021). The key genes of autophagy (e.g., autophagyrelated homolog 5 [ATG5], ATG7, DRAM3, and TFEB) are regulated by several canonical pathways including the PI3K-AKT-mTOR (Y. T. Wu et al, 2009) Abbreviations: ALKBH5, α-ketoglutarate-dependent dioxygenase alkB family member 5; AML, acute myeloid leukemia; BC, breast cancer; CRC, colorectal cancer; CXCR4, C-X-C motif chemokine receptor 4; DLBCL, diffuse large B-cell lymphoma; EC, endometrial cancer; ETS1, ETS proto-oncogene 1; FTO, fat mass and obesity-associated protein; GBM, glioblastoma; GC, gastric cancer; HCC, hepatocellular carcinoma cell; HIF-1α, hypoxia-inducible factor-1α; IGF2BP, insulin-like growth factor 2 mRNA-binding protein; m 6 A, N 6 -methyladenosine; METTL3, methyltransferase-like 3; NSCLC, non-small cell lung cancer; OC, ovarian cancer; PDACpancreatic ductal adenocarcinoma; PTC, papillary thyroid carcinoma; WTAP, Wilms tumor 1-associated protein.…”

Section: Network Of Rcd Mechanisms In Cancer Cellsmentioning

confidence: 99%

“…After canonical cell death and apoptosis were identified, substantial efforts were made to identify other types of RCD, such as autophagy, ferroptosis, pyroptosis, and necroptosis. When autophagy is initiated, cells undergo morphological changes, including the formation of double‐membraned autophagosomes and fusion with lysosomes as autolysosomes to drive the suicide process (Y. Wang, Mo, et al, 2021). The key genes of autophagy (e.g., autophagy‐related homolog 5 [ ATG5 ], ATG7 , DRAM3 , and TFEB ) are regulated by several canonical pathways including the PI3K‐AKT‐mTOR (Y. T. Wu et al, 2009), MAPK‐ERK1/2‐mTOR (Ferreira‐Marques et al, 2021), and SIRT1‐FOXO1 signaling pathways (Mei et al, 2020).…”

Section: Network Of Rcd Mechanisms In Cancer Cellsmentioning

confidence: 99%

Potential applications of N⁶‐methyladenosine modification in the prognosis and treatment of cancers via modulating apoptosis, autophagy, and ferroptosis

Yuan

Zhang

et al. 2022

WIREs RNA

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N6‐methyladenosine (m6A) is one of the most abundant modifications determining the fate of RNA. Currently, m6A modification is tightly connected with tumorigenesis and presents novel promise in clinical applications. Regulated cell death (RCD) is a programmed mechanism that plays a complicated role in malignant transition. Regarding the main forms of RCD, aberrant levels of m6A modification have been detected during the progression of apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis in several diseases. However, few reviews have elucidated the correlation between m6A‐modified RCD and carcinogenesis. In this review, we summarize the regulators of m6A methylation and their functions in carcinogenesis through an overview of m6A‐modified RCD. Additionally, we assume the potential role of m6A modification regulators as novel biomarkers for chemotherapies and precision medicine. Furthermore, we review the controversies and conflicts in m6A explorations and predict future orientations of m6A‐modified RCD for clinical applications. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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“…The circRNAs play essential roles in human diseases and are considered to be ideal biomarkers of these diseases due to their high stability [ 165 ]. Evidence has shown that circRNAs influence the course of a disease by regulating autophagy [ 166 ]. For example, following binding with MIR139-5p, circEIF3K inhibits the functions of MIR139-5p, the phosphorylation of MAPK/Erk, and the expression of BCL2, which promotes the autophagy in somatic inflammatory cells of patients with tubal inflammation, thereby inhibiting cell vitality and promoting apoptosis [ 167 ].…”

Section: Epigenetic Control Of Autophagymentioning

confidence: 99%