2011
DOI: 10.1002/jor.21526
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The influence of Co–Cr and UHMWPE particles on infection persistence: An in vivo study in mice

Abstract: Wear of metal-on-metal (cobalt-chromium, Co-Cr particles) and metal-on-polyethylene (ultra-high-molecular-weight polyethylene, UHMWPE particles) bearing surfaces in hip prostheses is a major problem in orthopedics. This study aimed to compare the influence of Co-Cr and UHMWPE particles on the persistence of infection. Bioluminescent Staphylococcus aureus Xen36 were injected in air pouches prepared in subcutaneous tissue of immuno-competent BALB/c mice (control), as a model for the joint space, in the absence o… Show more

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Cited by 19 publications
(12 citation statements)
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“…In a subsequent in vivo study, it was found that Co–Cr particles showed a similar infection burden as UHMWPE particles in four of six mice, with two cases showing significantly increased levels of infection. The increase in these animals was attributed to a possible reduction in macrophage function by the Co–Cr particles [27]. This theory is supported by evidence showing that both soluble and particulate debris derived from CoCrMo can induce monocyte–macrophage activation and the secretion of numerous proinflammatory cytokines [28].…”
Section: Host Response To Biomaterials and Infectionmentioning
confidence: 96%
“…In a subsequent in vivo study, it was found that Co–Cr particles showed a similar infection burden as UHMWPE particles in four of six mice, with two cases showing significantly increased levels of infection. The increase in these animals was attributed to a possible reduction in macrophage function by the Co–Cr particles [27]. This theory is supported by evidence showing that both soluble and particulate debris derived from CoCrMo can induce monocyte–macrophage activation and the secretion of numerous proinflammatory cytokines [28].…”
Section: Host Response To Biomaterials and Infectionmentioning
confidence: 96%
“…[27,28] Polytetrafluoroethylene coating on orthodontic brackets minimized biofilm formation, but it was partially abraded on surfaces exposed to high shear forces. [30] [30] …”
Section: Mechanical Stabilitymentioning
confidence: 99%
“…Hosman, Van Der Mei, Bulstra, Busscher, and Neut () have shown that higher levels of Co 2+ and Cr 3+ ions in the implant proximity reduced biofilm formation. In contrast, a mouse study showed an opposite effect with Co‐Cr debris, which was attributed to the reduction of the host immune response function caused by the presence of the metal particulates (Hosman et al, ).…”
Section: Prosthetic‐related Infections: Causes and Treatment Approachesmentioning
confidence: 99%