The influence of complex drug cocarnit on the nerve conduction velocity in nerve tibialis of rats with diabetic polyneuropathy

Abstract

We have analysed the influence of complex drug cocarnit (20 mg nicotinamide, 50 mg cocarboxylase, 0.5 mg cyanocobalamin, 10 mg disodium adenosine triphosphate trihydrate) on the nerve conduction velocity in nervus tibialis of rats with diabetic polyneuropathy. Our data shows that diabetic polyneuropathy leads to dysfunction of signal conduction to the effector. Administration of complex drug cocarnit showed linear dose-dependent therapeutic effect on pathology. After 9 d course administration in rats with diabetic polyneuropathy Cocarnit led to almost complete time parameters renewal of stimulation impulses but only with the presence of long relaxation periods between the contractions. Cocarnit has great prospects as a remedy for diabetic polyneuropathy therapy.

Protective Effect of Water-Soluble C60 Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats

“…Stimulation of the efferents was performed by electric impulses with a frequency of 1 to 50 Hz, and the duration of each pulse was 2 ms, formed by using a pulse generator. A control of the external load on the muscle was carried out with the help of an original mechanical stimulator [44]. In the process of analyzing the obtained results, the next parameter was used, namely the integrated muscle power (calculated area under the force curve), which is an indicator of the general performance of the muscle with the applied stimulation pools.…”

The Residual Effect of C60 Fullerene on Biomechanical and Biochemical Markers of the Muscle Soleus Fatigue Development in Rats

“…The dynamic properties of muscle contraction were studied under conditions of muscle activation using the method of modulated efferent stimulation [34]. Fatigue was induced by successive stimulation impulses with a frequency of 50 Hz and a duration of 5 s each, without a relaxation period between them.…”

“…We compared antioxidant enzymes isolated from the blood of the studied animals and the tissues of the muscle subjected to stimulation fatigue. Inflammatory processes occurring immediately after the onset of fatigue in skeletal muscle are a source of ROS and contribute to the intensification of LPO processes [34,35]. This interferes with the adequate performance of muscle work and significantly increases the recovery period.…”

Analysis of Skeletal Muscle Contraction of Chronic Alcoholic Rats under the Action of Water-Soluble С60 Fullerene

“…Для підготовки до модульованої стимуляції еферентів перерізали вентральні корінці безпосередньо в місцях їхнього виходу зі спинного мозку. Силу скорочення м'яза вимірювали за допомогою ориґінальних тензодатчиків, розташованих у задній частині мікропіпетки, до передньої частини якої приєднували сухожилок досліджуваного м'яза [23]. Для формування стимулювальних сиґналів використовували програмовані ґенератори сиґналів спеціяльної форми [24].…”