The Influence of Cortico-Cerebellar Structural Connectivity on Cortical Excitability in Chronic Stroke

Guder, Stephanie; Frey, Benedikt M.; Backhaus, Winifried; Braaß, Hanna; Timmermann, Jan E.; Gerloff, Christian; Schulz, Robert

doi:10.1093/cercor/bhz169

Cited by 28 publications

(34 citation statements)

References 79 publications

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“…Previous DTI studies also showed decreased FA in the midbrain of stroke patients by manually plotting ROIs (Wei et al, 2019). A recent study indicated that the cerebellum plays a role in residual motor output by facilitating cortical excitability in chronic stroke (Guder et al, 2020). Taken together, these ndings suggest that the inability to perform normal movements might gradually lead to abnormal balance, which is re ected in decreased cortico-cerebellar connectivity in these patients.…”

Section: The Cerebellummentioning

confidence: 80%

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions

Cao¹,

Wang

Chen

et al. 2021

Preprint

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Diffusion tensor imaging (DTI) studies have revealed distinct white matter characteristics of the brain following diseases. Beyond the lesion-symptom maps, stroke is characterized by extensive structural and functional alterations of brain areas remote to local lesions. Here, we further investigated the structural changes over a global level by using DTI data of ten ischemic stroke patients showing motor impairment due to basal ganglia lesions and 11 healthy controls. DTI data were processed to obtain fractional anisotropy (FA) maps, and multivariate pattern analysis (MVPA) was used to explore brain regions that play an important role in classification based on FA maps. The white matter (WM) structural network was constructed by the deterministic fiber-tracking approach. In comparison with the controls, the stroke patients showed FA reductions in the perilesional basal ganglia, brainstem, and bilateral frontal lobes. Using network-based statistics (NBS), we found a significant reduction in the WM subnetwork in stroke patients. We identified the patterns of WM degeneration affecting brain areas remote to the lesions, revealing the abnormal organization of the structural network in stroke patients, which may be helpful in understanding of the neural mechanisms underlying hemiplegia.

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Section: The Cerebellummentioning

confidence: 80%

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions

Cao¹,

Wang

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous DTI studies also found a decrease in FA in midbrain after stroke by manually plotting ROI [38]. A recent study found the role of the cerebellum for residual motor output by facilitating cortical excitability in chronic stroke [45]. The changes of cortico-cerebellar structural connectivity was probably caused by brain injuries related to the neural bers connecting to cerebellum, but the inability of normal movement may gradually lead to abnormal balance that re ected in the decreases of cortico-cerebellar connectivity.…”

Section: Cerebellummentioning

confidence: 90%

Pattern of white matter degeneration in remote brain areas from the basal ganglion lesion of ischemic stroke patients with motor impairment

Cao¹,

Wang²,

Chen

et al. 2020

Preprint

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Abstract Background Diffusion tensor imaging (DTI) studies have revealed distinct white matter characteristic of brain following diseases. Beyond the lesion-symptom mapping, recent studies have demonstrate extensive structural and functional alterations of remote areas to local lesions caused by stroke in the brain. Here, we investigated the influences further from a global level by multivariate pattern analysis (MVPA) and network-based statistic (NBS). Methods Ten ischemic stroke patients with basal ganglia lesion and motor dysfunction and eleven demographically matched adults underwent brain Magnetic Resonance Imaging scans. DTI data was processed to obtain fractional anisotropy (FA) map and MVPA was used to explore brain regions that play an important role in classification based on FA map. White matter (WM) structural network was constructed by the deterministic fiber tracking approach according to the Automated Anatomical Labeling (AAL) atlas. NBS was used to explore differences of structural network between groups. Results MVPA applied to FA images correctly identified stroke patients with a statistically significant accuracy of 100% (P ≤ 0.001). Compared with the controls, the patients showed an FA reduction in the perilesional basal ganglia and brainstem, with a few in bilateral frontal lobes. Using NBS, we found the significant decreased FA-weighted WM subnetwork in stroke patients. Conclusions We identified some patterns of WM degeneration in the affected brain areas remote from the ischemic lesion, revealed the abnormal topological organization of WM network in stroke patients, which may be helpful for understanding of the neural mechanism of stroke sequela.

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“…The CPT is associated with hand dominance-related alterations ( Kim et al, 2019 ). In addition, previous researches have demonstrated that the integrity of the CPT in patients with chronic stroke affects the residual upper limb function ( Schulz et al, 2015 ; Guder et al, 2020 ). A positive association was observed between the FA of the left FPT and the upper limb sub-score, which concurs with the association between the FA of the CPT and the finger-tapping-score in ALS patients ( Kalra et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Brainstem Involvement in Amyotrophic Lateral Sclerosis: A Combined Structural and Diffusion Tensor MRI Analysis

Zhang

Jin

et al. 2021

Front. Neurosci.

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IntroductionThe brainstem is an important component in the pathology of amyotrophic lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural changes in ALS patients, few studies have investigated structural alterations in the brainstem. Herein, we compared the brainstem structure between patients with ALS and healthy controls.MethodsA total of 33 patients with ALS and 33 healthy controls were recruited in this study. T1-weighted and diffusion tensor imaging (DTI) were acquired on a 3 Tesla magnetic resonance imaging (3T MRI) scanner. Volumetric and vertex-wised approaches were implemented to assess the differences in the brainstem’s morphological features between the two groups. An atlas-based region of interest (ROI) analysis was performed to compare the white matter integrity of the brainstem between the two groups. Additionally, a correlation analysis was used to evaluate the relationship between ALS clinical characteristics and structural features.ResultsVolumetric analyses showed no significant difference in the subregion volume of the brainstem between ALS patients and healthy controls. In the shape analyses, ALS patients had a local abnormal surface contraction in the ventral medulla oblongata and ventral pons. Compared with healthy controls, ALS patients showed significantly lower fractional anisotropy (FA) in the left corticospinal tract (CST) and bilateral frontopontine tracts (FPT) at the brainstem level, and higher radial diffusivity (RD) in bilateral CST and left FPT at the brainstem level by ROI analysis in DTI. Correlation analysis showed that disease severity was positively associated with FA in left CST and left FPT.ConclusionThese findings suggest that the brainstem in ALS suffers atrophy, and degenerative processes in the brainstem may reflect disease severity in ALS. These findings may be helpful for further understanding of potential neural mechanisms in ALS.

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The Influence of Cortico-Cerebellar Structural Connectivity on Cortical Excitability in Chronic Stroke

Cited by 28 publications

References 79 publications

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions

Pattern of white matter degeneration in remote brain areas from the basal ganglion lesion of ischemic stroke patients with motor impairment

Brainstem Involvement in Amyotrophic Lateral Sclerosis: A Combined Structural and Diffusion Tensor MRI Analysis

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