The influence of COVID-19 on routine hematological parameters of hospitalized patients

Abstract

Objectives: Coronavirus disease 2019 (COVID-19) was first discovered in Wuhan, China, in December 2019, and soon spread around the entire world. As no effective treatment is known, prediction of disease severity is very important in order to estimate a patients outcome. Aim of this study was to evaluate routine hematology parameters in time after admission. Methods: Data from routine blood analyses from confirmed COVID-19 cases admitted to the University Hospital of Leuven in Belgium were collected. COVID-19 patients (n = 197) were assigned to three groups: a 'non-ICU' group, a 'ICU' group and a 'deceased' group. A control group of 60 Influenza A (non-COVID-19) patients was also included. The parameters evaluated were platelet count (PLT, 10 9 /L), hemoglobin concentration (Hb, g/dL), leukocyte count (LEU, 10 9 /L), neutrophil count (NEU, %), eosinophil count (EO, %), lymphocyte count (LYM, %) and monocyte count (MONO, %). Results: Deceased COVID-19 patients had significant lower platelet count, higher leukocyte/ neutrophil count, and lower eosinophil/lymphocyte/monocyte count compared to recovered patients. Especially lymphocyte count showed important differences; they were significantly lower between day 9 and 12 after admission making this time window important in predicting clinical worsening of a patient. Conclusion: Patients with COVID-19 with poor outcome showed significant differences in results of routine hematological parameters compared with patients that recovered. Especially lymphocyte count can be helpful in the prediction of a patients outcome.

Impact of Covid-19 on Hematological Parameters-a Single Centre Study, India.

“…Although 13.9% of patient showed leucocytosis and high ANC in 14 15.6% ,this was similar to a study done by Blomme S et al . ,leucocytosis and high neutrophil count was observed due to superimposed bacterial infection that plays an important role in Covid-19 patients outcome.…”

Alterações hematológicas e hemostasia na COVID-19: uma revisão de literatura

“…Leucopenia Qin et al, (2020); Huang, C. et al, (2020); Guan et al, (2020); Ye et al, (2020) Linfopenia Zhang, J. et al, (2020); Fan et al, (2020); Qin et al, (2020); Huang, C. et al, (2020); ; Diao et al, (2020); Guan et al, (2020); Sun et al, (2020); Wang, D. et al, (2020); Zheng et al, (2020); ; Ye et al, (2020); Ding et al, (2020); ; Yuan et al, (2020); ; Wang, Lizhen et al, (2020); Blomme et al, (2020); Guclu et al, (2020); Bao et al, (2020) Leucocitose Sun et al, (2020); Wang, D. et al, (2020); Ye et al, (2020); Blomme et al, (2020); Guclu et al, (2020) Neutrofilia Fan et al, (2020); Sun et al, (2020); Wang, D. et al, (2020); Zheng et al, (2020) Alterações Morfológicas Zini et al, (2020); Jones e Ireland (2020); Taha et al, (2020) Agregação Plaquetária Guclu et al, (2020); Hottz et al, (2020); Manne et al, (2020); Taha et al, (2020) PDW aumentado Guclu et al, (2020); Zhang, S. et al, (2020) VPM aumentado Guclu et al, (2020); Taha et al, (2020); Zhang, S. et al, (2020) Fonte: Autores. Na população chinesa com COVID-19, estudos têm demonstrado a presença de leucopenia, ou seja, baixo nível de glóbulos brancos no sangue durante a internação, basicamente às custas de li...…”

“…Quin et al, 2020) . A linfopenia (baixo nível de linfócitos) na COVID-19 parece ser a alteração hematológica mais frequente, pois ela funciona como biomarcador de gravidade da infecção, logo, os linfócitos podem ser utilizados como triagem para diagnóstico de exames e para monitoramento da evolução de casos graves (Blomme;Smets;Ranst;Boeckx;Laer, 2020).…”

“…;Ye et al, (2020);Blomme et al, (2020);;Guclu et al, (2020); Bao et al, (2020) Aumento de NLR Qin et al, (2020); Ye et al, (2020); Ding et al, (2020); Zheng et al, (2020); Chen, R. et al, (2020) Eosinopenia Zhang, J. et al, (2020); Qin et al, (2020); Chen, R. et al, (2020); Xie et al, (2020); Tan et al, (2020) Alterações Morfológicas Fan et al, (2020); Zini et al, (2020); Nazarullah et al, (2020); Jones e Ireland (2020) Eritrograma Redução de Hemoglobina Fan et al, (2020); Huang, C. et al, (2020); Sun et al, (2020); Guan et al, (2020); Chen, N. et al, (2020); Yuan et al, (2020); Huang, Y. et al, (2020); Wang, Lizhen et al, (2020); Blomme et al, (2020); Lazarian et al, (2020); Djakpo et al, (2020); Wang, C. et al, (2020); Algassim et al, (2020); Torti et al, (2020); Bellmann-Weiler et al, (2020); Lansiaux et al, (2020); Mironova et al, (2020) RDW aumentado Foy et al, (2020); Wang, C. et al, . et al (2020); Wang, X. et al, (2020); Wang, Lang et al (2020); Manne et al, (2020); Bao et al, (2020); Tang et al, (2020); Guclu et al, (2020); Zhang, S. et al, (2020); Huang, C. et al, (2020); Guan et al, (2020) TrombocitoseWang, Lang et al, (2020);Taha et al, (2020) …”

Alterações leucocitárias em pacientes com COVID-19 observadas em extensão de sangue periférico

“…Sabe-se que o SARS-CoV-2 afeta a hematopoiese e o sistema imunológico durante seu desenvolvimento (Ahnach et al., 2020), isso ocasiona danos aos leucócitos e, por consequência, causa uma resposta imune ineficiente fazendo com que o organismo fique mais vulnerável a infecções (Blomme et al, 2020). Portanto, a observação dos parâmetros hematológicos concedidos pelo hemograma de rotina são de grande valia para acompanhar a progressão da doença .…”