1996
DOI: 10.1016/0093-691x(96)84759-5
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The influence of cytoplasmic age on the development of embryos made by nuclear transfer

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“…Other studies have examined structural and functional reprogramming events in reconstructed embryos, including nucleolar and mitochondrial morphology (31), nuclear swelling (32), and the exchange of somatic histone H1 subtypes (25). These studies have demonstrated that nuclear reprogramming takes place over several cell cycles and may be delayed or incomplete in the transferred nucleus (32,33). Recently, a differential display analysis that compared cDNA profiles between nuclear-transferred bovine blastocysts with in vivo-and in vitro-derived blastocysts demonstrated that most but not all of the mRNAs are reprogrammed in cloned embryos (34).…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have examined structural and functional reprogramming events in reconstructed embryos, including nucleolar and mitochondrial morphology (31), nuclear swelling (32), and the exchange of somatic histone H1 subtypes (25). These studies have demonstrated that nuclear reprogramming takes place over several cell cycles and may be delayed or incomplete in the transferred nucleus (32,33). Recently, a differential display analysis that compared cDNA profiles between nuclear-transferred bovine blastocysts with in vivo-and in vitro-derived blastocysts demonstrated that most but not all of the mRNAs are reprogrammed in cloned embryos (34).…”
Section: Discussionmentioning
confidence: 99%