The Influence of Delivery Mode on Biological Inactive Renin Level in Umbilical Cord Blood

Fujimura, Akio; Morimoto, Shinji; Uchida, Keiji; Takeda, Ryoyu; Ohshita, Michio; Ebihara, Akio

doi:10.1093/ajh/3.1.23

Cited by 3 publications

(2 citation statements)

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“…In a further study, though blood pressure at birth was the same, during the first 24 h post partum the blood pressure of the VD infants increased to a greater extent than that of the CS infants, producing a significant difference in blood pressure at 24 h post partum (Gemelli et al , 1992). This finding may be attributable to differences in the renin‐angiotensin‐aldosterone system (Broughton Pipkin et al , 1974; Fujimura et al , 1990; Oliveira Filho & Procianoy, 1995).…”

Section: Short‐term Physiological Changes In Response To Caesarementioning

confidence: 99%

“…Two studies report an increase in plasma TSH concentration (Bird et al , 1996; Ramezani Tehrani et al , 2003), although one study found the reverse (Miyamoto et al , 1991); the reason for this discrepancy is unclear and further work is required to establish the dynamics of TSH after different modes of delivery. The plasma concentration of biologically active renin is reduced in CS neonates (Fujimura et al , 1990), possibly as a result of the increase in cord blood pH (Tetlow & Broughton Pipkin, 1983). Consistent with this finding, plasma angiotensin II concentration is reduced ( P = 0.03) in CS neonates (Broughton Pipkin et al , 1974; Kingdom et al , 1993; Lumbers & Reid, 1977).…”

Section: How Might Plcs Account For These Physiological Differences?mentioning

confidence: 99%

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The health implications of birth by Caesarean section

Hyde¹,

Mostyn²,

Modi³

et al. 2011

Biological Reviews

188

165

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Since the first mention of fetal programming of adult health and disease, a plethora of programming events in early life has been suggested. These have included intrauterine and postnatal events, but limited attention has been given to the potential contribution of the birth process to normal physiology and long-term health. Over the last 30 years a growing number of studies have demonstrated that babies born at term by vaginal delivery (VD) have significantly different physiology at birth to those born by Caesarean section (CS), particularly when there has been no exposure to labour, i.e. pre-labour CS (PLCS). This literature is reviewed here and the processes involved in VD that might programme post-natal development are discussed. Some of the effects of CS are short term, but longer term problems are also apparent. We suggest that VD initiates important physiological trajectories and the absence of this stimulus in CS has implications for adult health. There are a number of factors that might plausibly contribute to this programming, one of which is the hormonal surge or "stress response" of VD. Given the increasing incidence of elective PLCS, an understanding of the effects of VD on normal development is crucial.

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Section: Short‐term Physiological Changes In Response To Caesarementioning

confidence: 99%