The influence of depression on risk development of acute cardiovascular diseases in the female population aged 25–64 in Russia

Гафаров, В. В.; Panov, D.; Громова, Е. А.; Гагулин, И. В.; Гафарова, А. В.

doi:10.3402/ijch.v72i0.21223

Cited by 20 publications

(18 citation statements)

References 16 publications

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“…To the best of our knowledge, this is the first open-label observational study to examine the efficacy and safety of fluvoxamine-based treatment in Russian patients with depression under uncontrolled routine settings. The high percentage of female patients with depression (72%) in this study is line with other published reports [24] [25] reporting high prevalence of depression in Russian females in comparison with the male population; similarly observed worldwide.…”

Section: Discussionsupporting

confidence: 92%

Fluvoxamine in Treatment of Depression in Russian Patients: An Open-Label, Uncontrolled and Non-Randomized Multicenter Observational Study

Smulevich¹,

Ilyina²

2015

OJPsych

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Background: Fluvoxamine, a selective serotonin reuptake inhibitor is widely used in the treatment of depression, one of the most common disorders prevalent in Russia. However, studies demonstrating its efficacy and safety in routine settings in Russia are scarce. Methods: This prospective, uncontrolled, open-label study was conducted at 11 centers in Russia. Total 293 patients (aged ≥ 18 years), meeting DSM-IV criteria for depression and scoring ≥ 17 on 17-item Hamilton Rating Scale of Depression (HAMD-17) received fluvoxamine 50-300 mg for 6 weeks. Primary efficacy measures included change from baseline in the HAMD-17 and Clinical Global Impression (CGI) scores. Secondary efficacy measure was evaluation of sleep quality changes on HAMD-17 subscale. Safety was assessed by monitoring of adverse drug reactions (ADRs). Results: Mean age of patients was 42.7 years and the majority of them were women (72%). At the end of treatment (day 42), clinically significant reduction was observed in mean HAMD-17, CGI-severity of illness and HAMD-17 sleep sub-score from 23.1, 4.5 and 3.9 at baseline to day 42; change from baseline (∆) was: ∆-17.3 [95% CI: −18.0; −16.7]), ∆-2.1 and ∆-3.4 [95% CI: −3.53; −3.20]), respectively. At day 42, 20.8% patients reported as normal (not at all ill) on the CGI-severity scale and 85% patients reported as "much improved" or "very much improved" on the CGI-change in severity and quality of life scores. Nausea (12.6%) and somnolence (5.1%) were the most frequently reported ADRs. No deaths or serious ADRs were reported but eight patients discontinued treatment due to ADRs. Conclusion: Treatment with fluvoxamine under routine settings showed marked improvement in Russian patients with depression as measured by HAMD-17 and CGI ratings and was thus efficacious as well as safe and well-tolerated.

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Section: Discussionsupporting

confidence: 92%

Fluvoxamine in Treatment of Depression in Russian Patients: An Open-Label, Uncontrolled and Non-Randomized Multicenter Observational Study

Smulevich¹,

Ilyina²

2015

OJPsych

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“…Three of our initially included reports could not be analyzed because of missing CIs 52 and an asymmetric CI. 86 Unadjusted analyses of psychological factors and incident IHD including 54 separate reports focusing on women and 78 reports on men resulted in pooled HRs of 1.39 (95% CI, 1.29-1.50) and 1.39 (95% CI, 1.32-1.47), respectively (Table S4). No significant betweengroup S&G differences for the risk of combined psychological factors for IHD incidence were found (P=0.996).…”

Section: Subgroup Analysesmentioning

confidence: 99%

Sex‐ and Gender‐Stratified Risks of Psychological Factors for Incident Ischemic Heart Disease: Systematic Review and Meta‐Analysis

Smaardijk

Lodder

Kop

et al. 2019

JAHA

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Background Psychological factors are associated with an increased risk of developing ischemic heart disease ( IHD ). Women more often report psychological factors, and sex and gender differences are present in IHD . In this meta‐analysis we examine the risks of psychological factors for IHD incidence in women and men. We hypothesize that a broad range of psychological factors are related to a higher risk for incident IHD , with a higher risk for women. Methods and Results PubMed, EMBASE , and Psyc INFO were searched for studies assessing the risk between psychological factors and incident IHD . Psychological factors included depression, anxiety or panic disorder, social support, hostility, anger, personality (type D), type A behavior pattern, posttraumatic stress disorder, and psychological distress. In the primary analyses, 62 studies (77 separate reports) that included 2 145 679 women and 3 119 879 men and reported confounder‐adjusted hazard ratios or relative risks were included. Pooled effect confounder‐adjusted estimates from random‐effects models showed that psychological factors (all combined) were associated with incident IHD in women (hazard ratio: 1.22; 95% CI , 1.14–1.30) and men (hazard ratio: 1.25; 95% CI , 1.19–1.31). No sex and gender differences were found for these pooled effect estimates ( P =0.547). Conclusions Psychological factors are associated with incident IHD in both women and men, but no significant differences were observed between women and men. IHD is predominantly being studied as obstructive coronary artery disease, which is more prevalent in men. Data are needed on psychological predictors and other manifestations of IHD such as coronary microvascular disease, which is more common in women.

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“…Отношение к работе и профилактическим проверкам своего здоровья в открытой популяции женщин 25-64 лет в зависимости от возраста Стресс на работе и его влияние на риск развития инфаркта миокарда, инсульта у женщин особенно для работниц с маленькими детьми [10]. И, не-смотря на то что конфликт семья-карьера рассматривает оба пола, у женщин этот дисбаланс выражен в большей мере [11][12][13]. Полученные данные показали, что 42% женщин не особенно нравиться их работа.…”

Section: Discussionunclassified

Workplace stress and its impact on the 16-year risk of myocardial infarction and stroke in an open female population aged 25—64 years in Russia/Siberia (WHO MONICA-psychosocial program)

Vv¹,

Panov²,

Ea³

et al. 2015

Ter. arkh.

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РезюмеЦель исследования. Определить влияние стресса на рабочем месте на отношение риска (ОР; HR) развития инфаркта миокарда (ИМ) и инсульта в открытой популяции женщин 25-64 лет в течение 16 лет в России/Сибири (Новосибирск). Материалы и методы. В рамках программы ВОЗ «MONICA-психосоциальная» в 1994 г. обследована случайная репрезентативная выборка 870 женщин в возрасте 25-64 лет -жительниц одного из района Новосибирска. Стресс на рабочем месте изучен с использованием шкалы Карасека; отношение к работе и профилактическим проверкам своего здоровья исследовано при помощи шкалы «Знание и отношение к своему здоровью» программы ВОЗ «MONICA-психосоциальная». В течение 16 лет (с 1994 по 2010 г.) в когорте исследовали все впервые возникшие случаи ИМ и инсульта с использованием программы ВОЗ «Регистр острого ИМ», всей возможной медицинской документации. Регрессионную модель Кокса использовали для определения ОР развития ИМ и инсульта в открытой популяции женщин 25-64 лет в течение 16 лет. Результаты. Распространенность высокого уровня стресса в открытой популяции женщин 25-64 лет составила 31,6%. Высокий уровень стресса на работе ассоциировался с высокой ответственностью, невозможностью отдохнуть в конце рабочего дня, частой профессиональной неудовлетворенностью и снижением трудоспособности. В течение 16 лет ОР развития ИМ был в 3,22 раза (p<0,05), инсульта -в 1,96 раза (p<0,05) выше у женщин с высоким уровнем стресса на работе. Частота возникновения ИМ и инсульта выше у замужних женщин, испытывающих стресс на работе, в категории «руководитель» и «физический труд» с высоким и низким уровнем образования. Заключение. Распространенность высокого уровня стресса на рабочем месте в открытой популяции России/Сибири (Новосибирск) у женщин 25-64 лет значительна. При нем ОР развития ИМ, инсульта в 3-2 раза выше, чем без высокого уровня стресса. На ОР развития ИМ, инсульта влияет социальный градиент. Results. The prevalence of high-level stress in the open female population aged 25-64 years was 31.6%. The high level of job stress was associated with a high responsibility, impossibility to have a rest at the end of a working day, frequent professional dissatisfaction, and a reduced work capacity. During 16 years, the women having high-level job stress showed a 3.22-and 1.96-fold increases in the HR of MI (p<0.05) and stroke (p<0.05), respectively. The incidence of MI and stroke was higher in married women expressing job stress as managers or manual laborers and having high and low educational attainment. Conclusion. The prevalence of high-level workplace stress was substantial in the open population of 25-64-year-old women in Russia/Siberia (Novosibirsk). The stress-related HR of MI and stroke was 3-2 times higher than in those without high-level stress. The HR of MI and stroke is affected by a social gradient.

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The influence of depression on risk development of acute cardiovascular diseases in the female population aged 25–64 in Russia

Cited by 20 publications

References 16 publications

Fluvoxamine in Treatment of Depression in Russian Patients: An Open-Label, Uncontrolled and Non-Randomized Multicenter Observational Study

Fluvoxamine in Treatment of Depression in Russian Patients: An Open-Label, Uncontrolled and Non-Randomized Multicenter Observational Study

Sex‐ and Gender‐Stratified Risks of Psychological Factors for Incident Ischemic Heart Disease: Systematic Review and Meta‐Analysis

Workplace stress and its impact on the 16-year risk of myocardial infarction and stroke in an open female population aged 25—64 years in Russia/Siberia (WHO MONICA-psychosocial program)

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