The Influence of Diet and Sex on the Gut Microbiota of Lean and Obese JCR:LA-cp Rats

Resch, Craig; Parikh, Mihir; Austria, J. Alejandro; Proctor, Spencer; Netticadan, Thomas; Blewett, Heather; Pierce, Grant N.

doi:10.3390/microorganisms9051037

Cited by 8 publications

(7 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the alpha diversity of the HW group was higher than that of the LW group, which was consistent with the research results on weaned piglets (Han et al, 2017). However, another study on rats found that the alpha diversity of obese rats was lower than that of lean rats (Resch et al, 2021). We speculate that this situation is due to possible differences in the composition and development of the GM between species.…”

Section: Discussionsupporting

confidence: 90%

Association between body weight and distal gut microbes in Hainan black goats at weaning age

Bian

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Gut microbiota plays a critical role in the healthy growth and development of young animals. However, there are few studies on the gut microbiota of young Hainan black goats. In this study, 12 three-month-old weaned lambs with the same birth date were selected and divided into the high body weight group (HW) and low body weight group (LW). The microbial diversity, composition, and predicted function in the feces of HW and LW groups were analyzed by collecting fecal samples and sequencing the 16S rRNA V3-V4 region. The results indicated that the HW group exhibited higher community diversity compared with the LW group, based on the Shannon index. The core phyla of the HW and LW groups were both Firmicutes and Bacteroidetes. Parabacteroides, UCG-005, and Bacteroides are the core genera of the HW group, and Bacteroides, Escherichia-Shigella, and Akkermansia are the core genera of the LW group. In addition, genera such as Ruminococcus and Anaerotruncus, which were positively correlated with body weight, were enriched in the HW group; those genera, such as Akkermansia and Christensenellaceae, which were negatively correlated with body weight, were enriched in the LW group. Differential analysis of the KEGG pathway showed that Amino Acid Metabolism, Energy Metabolism, Carbohydrate Metabolism, and Nucleotide Metabolism were enriched in the HW group, while Cellular Processes and Signaling, Lipid Metabolism, and Glycan Biosynthesis and Metabolism were enriched in the LW group. The results of this study revealed the gut microbial characteristics of Hainan black goats with different body weights at weaning age and identified the dominant flora that contributed to their growth.

show abstract

Section: Discussionsupporting

confidence: 90%

Association between body weight and distal gut microbes in Hainan black goats at weaning age

Bian

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…were minor components. Hence, it may be speculated that the genera present here were able to perform SDG degradation [ 48 ]. However, SECO was also not completely degraded to ED and EL in this study.…”

Section: Discussionmentioning

confidence: 99%

Dietary Modulation of the Human Gut Microbiota and Metabolome with Flaxseed Preparations

Kleigrewe

Haack

Baudin

et al. 2022

IJMS

View full text Add to dashboard Cite

Flaxseeds are typically consumed either as whole flaxseed, ground flaxseed, flaxseed oil, partially defatted flaxseed meal, or as a milk alternative. They are considered a rich source of vitamins, minerals, proteins and peptides, lipids, carbohydrates, lignans, and dietary fiber, which have shown hypolipidemic, antiatherogenic, anticholesterolemic, and anti-inflammatory property activity. Here, an in vitro batch culture model was used to investigate the influence of whole milled flaxseed and partially defatted milled flaxseed press cake on the gut microbiota and the liberation of flaxseed bioactives. Microbial communities were profiled using 16S rRNA gene-based high-throughput sequencing with targeted mass spectrometry measuring lignan, cyclolinopeptide, and bile acid content and HPLC for short-chain fatty acid profiles. Flaxseed supplementation decreased gut microbiota richness with Firmicutes, Proteobacteria, and Bacteroidetes becoming the predominant phyla. Secoisolariciresinol, enterodiol, and enterolactone were rapidly produced with acetic acid, butyric acid, and propionic acid being the predominant acids after 24 h of fermentation. The flaxseed press cake and whole flaxseed were equivalent in microbiota changes and functionality. However, press cake may be superior as a functional additive in a variety of foods in terms of consumer acceptance as it would be more resistant to oxidative changes.

show abstract

“…An increased abundance of Lactobacillus and Ruminococcus were also associated with lower HFF consumption. The abundances of these bacteria are disturbed in animal models fed a high-fat diet ( Daniel et al, 2014 ; Resch et al, 2021 ), which indicates that these taxa may not grow well in the gut in the presence of high-fat foods. Hence, in this study, lower reporting of HFF dietary behaviors among children perhaps favors the growth of these bacteria.…”

Section: Discussionmentioning

confidence: 99%

The fecal microbiota of Thai school-aged children associated with demographic factors and diet

Gruneck

Gentekaki

Kespechara³

et al. 2022

PeerJ

View full text Add to dashboard Cite

Background Birth delivery method and breastfeeding practices contribute to microbiota colonization. Other factors including diet and demographic factors structure the gut microbiome assembly and diversity through childhood development. The exploration of these factors, especially in Southeast Asian children, remains limited. Methods We investigated the fecal microbiota of 127 school-aged children in Thailand using quantitative PCR (qPCR) to assess the influence of diet and demographic factors on the gut microbiota. Multivariate analysis (multiple factor analysis (MFA) and Partial Least Squares Discriminant Analysis (PLS-DA)) were used to link particular gut microbes to diet and demographic factors. Results Diet and demographic factors were associated with variation among gut microbiota. The abundance of Gammaproteobacteria increased in children with infrequent intake of high fat foods. Obese children possessed a lower level of Firmicutes and Ruminococcus. Bifidobacterium was enriched in pre-teen aged children and detected at lower levels among formula-fed children. Prevotella was more abundant in children who were delivered vaginally. While ethnicity explained a small amount of variation in the gut microbiota, it nonetheless was found to be significantly associated with microbiome composition. Conclusions Exogenous and demographic factors associate with, and possibly drive, the assembly of the gut microbiome of an understudied population of school-aged children in Thailand.

show abstract

The Influence of Diet and Sex on the Gut Microbiota of Lean and Obese JCR:LA-cp Rats

Cited by 8 publications

References 66 publications

Association between body weight and distal gut microbes in Hainan black goats at weaning age

Association between body weight and distal gut microbes in Hainan black goats at weaning age

Dietary Modulation of the Human Gut Microbiota and Metabolome with Flaxseed Preparations

The fecal microbiota of Thai school-aged children associated with demographic factors and diet

Contact Info

Product

Resources

About