The influence of dietary fats on serum‐lipide levels in man

Ahrens, E. H.; Hirsch, Jules; Insull, William; Blomstrand, Rolf; Tsaltas, Theodore T.; Peterson, Malcolm L.

doi:10.1007/bf02638705

Cited by 11 publications

(13 citation statements)

References 16 publications

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“…Estudos anteriores já reportavam que dietas ricas em ácido graxo saturado aumentavam os níveis de colesterol sérico e aumentavam a incidência de doenças cardiovasculares, em especial a aterogênese (53,(57)(58)(59)(60)(61).…”

Section: Discussionunclassified

Hiperlipidemias e fatores dietéticos: estudo transversal entre nipo-brasileiros

Bevilacqua

Gimeno

Matsumura

et al. 2007

Arq Bras Endocrinol Metab

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RESUMOEste estudo teve como objetivo avaliar a associação entre hiperlipidemia e dieta de nipo-brasileiros de Bauru, município do Estado de São Paulo. Foram obtidos de 1.330 indivíduos dados mediante questionários previamente testados (dados demográficos e dietéticos). Os exames físicos e laboratoriais incluíram a coleta (ou dosagem) antropométrica, de pressão arterial, de glicemia de jejum e de 2 horas, de perfil lipídico e de TSH e T4 livre. Utilizaram-se teste qui-quadrado e medida de odds ratio para avaliar associação entre as variáveis estudadas e presença de hiperlipidemia. Foi encontrado 81,5% de hiperlipidêmicos e acometeu, principalmente, indivíduos tabagistas, com excesso de peso, hipotireoidismo, hipertensão arterial e intolerância a glicose. Observaram-se, mediante análise bruta, relações entre hiperlipidemia e ácido graxo saturado, ácido oléico e fibras de grãos e cereais. Após o ajuste para as variáveis de controle, observaram-se associações entre hiperlipidemia e consumo de lípides (totais, ácido oléico, saturados e trans), fibras e álcool. Conclui-se que mudanças no estilo de vida, particularmente no hábito alimentar, podem levar a uma melhora do quadro hiperlipidêmico e que o consumo de lípides pode ser um dos principais fatores para o aumento da hiperlipidemia. Estudos prospectivos auxiliarão para testar essas hipóteses nos nipo-brasileiros de Bauru. This study aimed at evaluating the association between hyperlipidemia and dietary patterns of Japanese Brazilians with and without hypothyroidism from Bauru, city in the State of São Paulo. We evaluated 1,330 individuals by means of demographic and dietary measurement, whom were gotten through standardized questionnaires previously tested. Clinical examination and laboratory data were anthropometry, blood pressure, fasting and 2-h glucose load, lipid profile and TSH and free T4. The chi-square and the odds ratio were used to evaluate associations between hyperlipidemia with studied variables. The prevalence of hyperlipidemia was 81.5% and it was associated with smokers, overweight, hypothyroid, hypertensive and glucose intolerants. We observed, in crude analysis, relationships with the presence of hyperlipidemia and fat saturated, oleic acid and dietary fiber from grains and cereals. After adjusting for the control variables, we observed relationships between hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) with habitual intake of total fat, oleic acid, saturated fat, trans fat, dietary fiber and alcohol. As a conclusion, changes in the style of life, particularly in the dietary habits, can improve lipidic profile and that lipids intake can be a risk factor for hyperlipidemia. Prospectives studies will help test the hypothesis in Japanese Brazilians from Bauru. (Arq Bras Endocrinol Metab 2007;51/4:547-558)

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Section: Discussionunclassified

Hiperlipidemias e fatores dietéticos: estudo transversal entre nipo-brasileiros

Bevilacqua

Gimeno

Matsumura

et al. 2007

Arq Bras Endocrinol Metab

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“…Later this point was clearly demonstrated by Ahrens et al, who showed that feeding two vegetable fats (coconut oil and corn oil) led to vastly different plasma cholesterol levels. 36 The iodine number (total unsaturation) of the oil, rather than its source, was found to be strongly correlated with the degree of cholesterol lowering. About the same time, it was shown that the addition of polyunsaturated fat to a fat-free diet resulted in a reduction in plasma cholesterol levels, which was of the same magnitude as the rise observed when saturated fats were added.…”

Section: Plasma Cholesterolmentioning

confidence: 99%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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“…Fatty acids of the chain length C12 and under are transported from the intestine via the portal blood to the liver instead of reaching the systemic venous circulation via the lymph as chylomicrons, the transport form of the absorbed long-chain fatty acids. Coconut oil does induce hypercholesterolemia in man (16). The periods of feeding have usually been 60 days or less, so that there is the possibility that even man might eventually adapt to coconut oil feeding.…”

Section: Discussionmentioning

confidence: 99%

Relative Failure of Saturated Fat in the Diet to Produce Atherosclerosis in the Rabbit

Connor

Rohwedder

Armstrong

1967

Circulation Research

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Three "saturated" fats of vegetable origin were fed to different groups of rabbits for periods up to 1 year. Cocoa butter and a hydrogenated vegetable oil shortening produced no hypercholesterolemia. Coconut oil feeding increased the serum cholesterol concentrations for 4 months, but a decline to baseline values occurred after 6 months. No gross atherosclerosis occurred in any animal fed coconut oil or the hydrogenated vegetable oil shortening. Slight atherosclerotic lesions were found in 50% of the rabbits fed cocoa butter. Aortic cholesterol content was slightly increased in animals fed coconut oil and cocoa butter. Dietary fats, even when highly saturated, had only a minimal capacity to produce atherosclerosis in the rabbit, a species usually highly susceptible to the induction of atherosclerosis. When a moderate amount of cholesterol was added to the diet, the serum cholesterol levels increased greatly and considerable atherosclerosis resulted.

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The influence of dietary fats on serum‐lipide levels in man

Cited by 11 publications

References 16 publications

Hiperlipidemias e fatores dietéticos: estudo transversal entre nipo-brasileiros

Hiperlipidemias e fatores dietéticos: estudo transversal entre nipo-brasileiros

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Relative Failure of Saturated Fat in the Diet to Produce Atherosclerosis in the Rabbit

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