The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C

Bandyopadhyay, Sulalit; Sharma, Anuvansh; Glomm, Wilhelm R.

doi:10.3390/gels3040042

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…Surfactants belonging to the quaternary ammonium group of the same family (CTAB, MTAB, and DTAB) were used for synthesis. The anisotropic structure reported in this work resembles nanomakura gold nanoparticles as reported elsewhere for the first time [ 12 ]. However, the synthesis reported in this work is conspicuously different in terms of synthesis protocol and chemical constituents used.…”

Section: Discussionsupporting

confidence: 77%

“…The growth solution used was kept uniform in case of all three surfactants to establish the specific effect of carbon tail length on the respective aspect ratios of the nanoparticles. The synthesis of gold nanomakura particles via seed-mediated growth has been discussed elsewhere [ 12 ]. However, the effect of different carbon tail lengths on optical, structural, chemical properties, and photothermal response has been established in the present work.…”

Section: Introductionmentioning

confidence: 99%

“…These technologies are based on the principle of elastic scattering properties of metal nanoparticles and on the shift in the plasmon band, which is more prominent in the case of anisotropic nanoparticles in comparison to isotropic ones [6]. Several anisotropic gold nanoparticles (AuNPs) have been synthesized and studied in recent years including nanorings, nanoprisms, nanoplates, crooked nanorods, dendrimers, nanocubes, nanodumbells, dogbones, and nanomakura [7][8][9][10][11][12][13][14]. Vis-à-vis to spherical nanoparticles, anisotropic nanoparticles do not require aggregation to generate hotspots due to readily obtained tunability of higher aspect ratios during synthesis [13].…”

Section: Introductionmentioning

confidence: 99%

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Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

Das,

Vikas,

Kumar

et al. 2024

Beilstein J. Nanotechnol.

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Photothermal conversion of light into heat energy is an intrinsic optical property of metal nanoparticles when irradiated using near-infrared radiation. However, the impact of size and shape on the photothermal behaviour of gold nanomakura particles possessing optical absorption within 600–700 nm as well as on incorporation in hydrogels is not well reported. In this study, nanomakura-shaped anisotropic gold nanoparticles (AuNMs) were synthesized via a surfactant-assisted seed-mediated protocol. Quaternary cationic surfactants having variable carbon tail length (n = 16, 14, 12) were used as capping for tuning the plasmon peak of gold nanomakura within a 600–700 nm wavelength. The aspect ratio as well as anisotropy of synthesized gold nanomakura can influence photothermal response upon near-infrared irradiation. The role of carbon tail length was evident via absorption peaks obtained from longitudinal surface plasmon resonance analysis at 670, 650, and 630 nm in CTAB-AuNM, MTAB-AuNM, and DTAB-AuNM, respectively. Furthermore, the impact of morphology and surrounding milieu of the synthesized nanomakuras on photothermal conversion is investigated owing to their retention of plasmonic stability. Interestingly, we found that photothermal conversion was exclusively assigned to morphological features (i.e., nanoparticles of higher aspect ratio showed higher temperature change and vice versa irrespective of the surfactant used). To enable biofunctionality and stability, we used kappa-carrageenan- (k-CG) based hydrogels for incorporating the nanomakuras and further assessed their photothermal response. Nanomakura particles in association with k-CG were also able to show photothermal conversion, depicting their ability to interact with light without hindrance. The CTAB-AuNM, MTAB-AuNM, and DTAB-AuNM after incorporation into hydrogel beads attained up to ≈17.2, ≈17.2, and ≈15.7 °C, respectively. On the other hand, gold nanorods after incorporation into k-CG did not yield much photothermal response as compared to that of AuNMs. The results showed a promising platform to utilize nanomakura particles along with kappa-carrageenan hydrogels for enabling usage on nanophotonic, photothermal, and bio-imaging applications.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

Das,

Vikas,

Kumar

et al. 2024

Beilstein J. Nanotechnol.

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“…Gold anisotropic nanostructures find important applications that encompass catalysis, sensing, and biomedicine, and their chemical synthesis has been recently reviewed [ 93 ]. There is an increasing interest towards the development of differently-shaped gold NPs and how morphology can be used to tune the properties of the final materials [ 94 ]. In particular, new methods are continuously sought for the controlled preparation of ultrathin gold nanowires [ 95 ], and gold nanorods [ 96 ].…”

Section: Inorganic Nanostructure-templating Effects By Peptidesmentioning

confidence: 99%

Peptide Gelators to Template Inorganic Nanoparticle Formation

Bellotto

Cringoli

Perathoner

et al. 2021

Gels

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The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to catalysis. In particular, short-peptide gelators offer the advantage of providing dynamic supramolecular environments for the templating effect on the formation of inorganic nanoparticles directly in the resulting gels, and ideally without using further reductants or chemical reagents. This mini-review describes the recent progress in the field to outline future research directions towards dynamic functional materials that exploit the synergy between supramolecular chemistry, nanoscience, and the interface between organic and inorganic components for advanced performance.

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“…The toxicity of CTAB and the role of CTAB in AuNRs synthesis have been detailed by many groups [ 22 , 23 ]. In 2017, Bandyopadhyay illustrated that the positive surface charge of CTAB induces cytotoxicity and hinders the adsorption of serum proteins onto the particle surface, which can alter the process of endocytosis [ 24 ]. The role of CTAB in complicating the biomedical applications of AuNRs was explained by Kohanloo et al, who determined the critical CTAB:nanorod concentration ratio to be approximately 740,000:1 to attain nanorods stability upon the formation of a CTAB double-layer, whereas experimentally, an even larger excess of CTAB is added [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Single-Step Photochemical Formation of Near-Infrared-Absorbing Gold Nanomosaic within PNIPAm Microgels: Candidates for Photothermal Drug Delivery

et al. 2020

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This work demonstrates the dynamic potential for tailoring the surface plasmon resonance (SPR), size, and shapes of gold nanoparticles (AuNPs) starting from an Au(I) precursor, chloro(dimethyl sulfide)gold (I) (Au(Me2S)Cl), in lieu of the conventional Au(III) precursor hydrogen tetrachloroaurate (III) hydrate (HAuCl4). Our approach presents a one-step method that permits regulation of an Au(I) precursor to form either visible-absorbing gold nanospheres or near-infrared-window (NIRW)-absorbing anisotropic AuNPs. A collection of shapes is obtained for the NIR-absorbing AuNPs herein, giving rise to spontaneously formed nanomosaic (NIR-absorbing anisotropic gold nanomosaic, NIRAuNM) without a dominant geometry for the tesserae elements that comprise the mosaic. Nonetheless, NIRAuNM exhibited high stability; one test sample remains stable with the same SPR absorption profile 7 years post-synthesis thus far. These NIRAuNM are generated within thermoresponsive poly(N-isopropylacrylamide) (PNIPAm) microgels, without the addition of any growth-assisting surfactants or reducing agents. Our directed-selection methodology is based on the photochemical reduction of a light-, heat-, and water-sensitive Au(I) precursor via a disproportionation mechanism. The NIRAuNM stabilized within the thermoresponsive microgels demonstrates a light-activated size decrease of the microgels. On irradiation with a NIR lamp source, the percent decrease in the size of the microgels loaded with NIRAuNM is at least five times greater compared to the control microgels. The concept of photothermal shrinkage of hybrid microgels is further demonstrated by the release of a model luminescent dye, as a drug release model. The absorbance and emission of the model dye released from the hybrid microgels are over an order of magnitude higher compared to the absorbance and emission of the dye released from the unloaded-control microgels.

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The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C

Cited by 10 publications

References 56 publications

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

Peptide Gelators to Template Inorganic Nanoparticle Formation

Single-Step Photochemical Formation of Near-Infrared-Absorbing Gold Nanomosaic within PNIPAm Microgels: Candidates for Photothermal Drug Delivery

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