The influence of environmental factors on behavioural problems in 8-year-old children exposed to amphetamine during fetal life

Billing, Lars; Eriksson, Margareta; Jonsson, Björn; Steneroth, Gun; Zetterström, Rolf

doi:10.1016/0145-2134(94)90091-4

Cited by 58 publications

(42 citation statements)

References 23 publications

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“…There are few studies available, however, where follow-up data has been collected. The most extensive study involved a study on prenatally exposed children from birth to 14 years of age in Sweden (122)(123)(124)(125)(126). While there are limitations with the study (small size of 65 children and no control group) at 4 years of age the study suggested that the children exhibited aggressive behaviour that seemed to correlate with longer in-utero exposure periods.…”

Section: Chronic Effectsmentioning

confidence: 99%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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AbstractThe clandestine manufacture of methamphetamine in residential homes may represent significant hazards and exposures not only to those involved in the manufacture of the drugs but also to others living in the home (including children), neighbours and first responders to the premises. These hazards are associated with the nature and improper storage and use of precursor chemicals, intermediate chemicals and wastes, gases and methamphetamine residues generated during manufacture and the drugs themselves. Many of these compounds are persistent and result in exposures inside a home not only during manufacture but after the laboratory has been seized or removed. Hence new occupants of buildings formerly used to manufacture methamphetamine may be unknowingly exposed to these hazards. Children are most susceptible to these hazards and evidence is available in the literature to indicate that these exposures may result in immediate and long-term adverse health effects. The assessment of exposure within the home can be undertaken by measuring contaminant levels or collecting appropriate biological data from individuals exposed. To gain a better understanding of the available data and key issues associated with these approaches to the characterisation of exposure, a review of the published literature has been undertaken.

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Section: Chronic Effectsmentioning

confidence: 99%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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“…However, 1 study of unspecified amphetamine use during pregnancy suggests a possible association with externalizing behaviors and peer problems. 225,226 Cognition/Executive Functioning…”

Section: Behaviormentioning

confidence: 99%

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

Behnke¹,

Levy²,

Ammerman³

et al. 2013

Pediatrics

497

389

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Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician’s role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition of medical issues for the exposed newborn infant, protection of the infant, and follow-up of the exposed infant. This report will provide information for the most common drugs involved in prenatal exposure: nicotine, alcohol, marijuana, opiates, cocaine, and methamphetamine.

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“…Among children exposed to amphetamine continuously throughout pregnancy, emotional characteristics of autism, speech problems and signs of wariness of strangers were noted by age one [5]. By age 4, IQ was lower than a normative group of Swedish children [6] and at age 8 prenatal exposure predicted aggressive behavior and problems with peers [4]. At age 14, the children showed problems with advancement in school due to delays in math and language and had difficulties with physical fitness activities [10].…”

Section: Introductionmentioning

confidence: 99%

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

164

127

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Background-Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown.Objective-To examine the neurobehavioral effects of prenatal MA exposure.Design-The Infant Development, Environment and Lifestyle (IDEAL) study screened 13,808 subjects and 1632 were eligible and consented. 166 (n=74 exposed) were enrolled in a longitudinal follow up. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. The NICU Network Neurobehavioral Scale (NNNS) was administered within the first 5 days of life. Analyses conducted on NNNS summary scores included exposure group effects, heavy MA use effects, association with frequency of use by trimester, and dose-response relationships with amphetamine metabolites.Results-After adjusting for covariates, exposure to MA was associated with increased physiological stress. Heavy MA use was related to lower arousal, more lethargy, and increased physiological stress. First trimester MA use was related to elevated physiological stress. Third trimester use was related to poorer quality of movement. Higher level of amphetamine metabolites in meconium was associated with increased CNS stress.Conclusions-Prenatal MA exposure was associated with neurobehavioral patterns of decreased arousal, increased stress, and poor quality of movement. The dose response relationships may represent neurotoxic effects from MA.

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The influence of environmental factors on behavioural problems in 8-year-old children exposed to amphetamine during fetal life

Cited by 58 publications

References 23 publications

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

Prenatal methamphetamine use and neonatal neurobehavioral outcome

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