The Influence of Epigallocatechin Gallate on the Nuclear Factor Associated T Cell-1 and Sclerostin Expression in Wistar Rats (<i>Rattus novergicus</i>) during the Orthodontic Tooth Movement

Hermawan, Rahendra Wira; Narmada, Ida Bagus; Djaharu’ddin, Irwadi; Nugraha, Alexander Patera; Rahmawati, Dwi

doi:10.5958/0974-360x.2020.00312.1

Cited by 13 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we were discriminated the osteoblast or osteoclast based on its morphology. Osteoclast's morphology has (1) multinucleated that attached on the bone surface with resorption area, (2) numerous mitochondria and vacuoles that can be seen in its cytoplasm;…”

Section: Discussionmentioning

confidence: 99%

“…32 NF-kβ activation is induced by interleukin (IL)-1β and TNF-α as proinflammatory cytokine during OTM. 1,2 The highest number of osteoclasts was found in the control group on day 7 (K2), while the lowest number of osteoclasts was found in the treatment group on day 14 (KP3). In this study, we were discriminated the osteoblast or osteoclast based on its morphology.…”

Section: Discussionmentioning

confidence: 99%

“… 32 NF-kβ activation is induced by interleukin (IL)-1β and TNF-α as proinflammatory cytokine during OTM. 1 2 …”

Section: Discussionmentioning

confidence: 99%

“…Teeth can move in the alveolar bone due to the inducement of orthodontic force in the form of mechanical pressure. 1 The inducement of orthodontic forces will initiate cellular and biochemical activities, accompanied by the remodeling of periodontal ligaments and alveolar bone. 2 The application of orthodontic forces for malocclusion treatment will begin the cellular and molecular signaling and regulation in the periodontal tissue.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objectives To investigate the effect of caffeic acid phenethyl ester (CAPE) provision on matrix metalloproteinase-9 (MMP-9), fibroblast growth factor-2 (FGF-2) expression, osteoclast and osteoblast numbers during experimental orthodontic tooth movement (OTM) in male Wistar rats (Rattus norvegicus). Materials and Methods Forty-eight healthy male Wistar rats (R. norvegicus), 16 to 20 weeks old with 200 to 250 g body weight (bw) were divided into several groups as follows: K1: OTM for 3 days; K2: OTM for 7 days; K3: OTM for 14 days; KP1: OTM and CAPE for 3 days; KP2: OTM and CAPE for 7 days; and KP3: OTM and CAPE for 14 days. A nickel titanium closed coil spring 8.0 mm long with 10 g/mm2 was installed between the upper left first molar and upper central incisor to move molar mesially. CAPE provision with a dose of 20 mg/kg bw of animal studies was done per orally. Immunohistochemistry was done to examine MMP-9 expression and osteoclast number in compression side as well as FGF-2 expression and osteoblast number in tensile side of the OTM. Statistical Analysis One-way analysis of variance test and Tukey’s honest significant difference test were performed to determine the difference between the groups (p < 0.05). Results MMP-9 expression and osteoclast numbers in the compression side were significantly different between the groups. Similarly, FGF-2 expression and osteoclast numbers in the tensile side were significantly different between the groups. Conclusions CAPE provision during OTM increases the number of osteoblasts and the FGF-2 expression significantly in the tensile side. Osteoclast numbers and MMP-9 expression significantly decrease in the compression side.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 32 NF-kβ activation is induced by interleukin (IL)-1β and TNF-α as proinflammatory cytokine during OTM. 1 2 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus)

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…One reported mechanism that explains the changes in bone remodeling in hyperglycemia is reduced bone formation due to decreased osteoblastic activity or increased apoptosis of osteoblasts and increased resorption activity in bone [8][9][10]. Changes in individual metabolism, which can interfere with bone remodeling, can produce the differences in the rate of orthodontic tooth movement (OTM) [11,12].…”

Section: Introductionmentioning

confidence: 99%

Receptor Activator of Nuclear Factor-Kappa Ligand and Osteoprotegerin Expressions on Hyperglycemic Wistar Rats (Rattus Novergicus) During Orthodontic Tooth Movement

Alida

Winoto

Narmada

2020

Pesqui. Bras. Odontopediatria Clín. Integr.

Self Cite

View full text Add to dashboard Cite

show abstract

Mobile application evaluation of the orthodontic treatment success and the degree of change based on the index of complexity, outcome, and need (ICON)

et al. 2022

View full text Add to dashboard Cite

The Influence of Epigallocatechin Gallate on the Nuclear Factor Associated T Cell-1 and Sclerostin Expression in Wistar Rats (Rattus novergicus) during the Orthodontic Tooth Movement

Cited by 13 publications

References 0 publications

Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus)

Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus)

Receptor Activator of Nuclear Factor-Kappa Ligand and Osteoprotegerin Expressions on Hyperglycemic Wistar Rats (Rattus Novergicus) During Orthodontic Tooth Movement

Mobile application evaluation of the orthodontic treatment success and the degree of change based on the index of complexity, outcome, and need (ICON)

Contact Info

Product

Resources

About