The influence of estrogen deficiency on the structural and mechanical properties of rat cortical bone

Shipov, Anna; Zaslansky, Paul; Riesemeier, H.; Segev, Gil; Atkins, Ayelet; Kalish-Achrai, Noga; Weiner, Stephen; Shahar, Ron

doi:10.7717/peerj.10213

Cited by 2 publications

(2 citation statements)

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“… 86 In particular, an increase in the mechanical strength of cortical bone was observed in ovariectomized rats with AAS use, a finding that led to the development of AAS as a potential lead for treating established osteoporosis associated with aging. 87 AAS has shown stimulation of endosteal bone formation. These findings have provided recommendations for AAS use particularly ND and nandrolone in estrogen-deficient conditions.…”

Section: Effects On Bonesmentioning

confidence: 99%

The Uses of Anabolic Androgenic Steroids Among Athletes; Its Positive and Negative Aspects- A Literature Review

Wenbo,

Yan

2023

JMDH

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The use of anabolic androgenic steroids (AAS) for strength training and muscle building is a widespread practice among athletes and young individuals. Athletes and bodybuilders are using these substances for various purposes, such as enhancing muscle mass, strengthening their bodies, and enhancing their performances. AAS exert a wide range of physiological effects that result in the activation of central signaling, resulting in adverse effects. Moreover, excessive use of AAS which can be categorized as AAS abuse; is linked to biological and psychological pathologies, which can lead to mortality. Complications arising from steroid abuse involve both cellular and physiological complications. Cellular complications arise when activation of signaling proteins like mTOR, Akt, etc. leads to alteration in protein synthesis pathways, cell cycle, oxidative stress, and apoptosis, contributing to damage at the cellular level. Physiological complications are evident with cardiovascular pathologies, including an altered lipid profile, cardiac hypertrophy, hypogonadism after discontinuation of AAS, and modulation of GABA receptors in the brain, all contributed by the androgen receptor signaling. Clinical complications budding from these altered physiological processes lead to clinical effects like testicular dysfunction, acne, gynecomastia, and neuropsychiatric disorders. Despite potential therapeutic benefits, AAS use is prohibited by the World Anti-Doping Agency (WADA) due to concerns over adverse health effects. This review highlights the molecular mechanisms, physiological processes, and clinical complications arising from the excessive use of AAS among athletes.

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Section: Effects On Bonesmentioning

confidence: 99%

The Uses of Anabolic Androgenic Steroids Among Athletes; Its Positive and Negative Aspects- A Literature Review

Wenbo,

Yan

2023

JMDH

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“…It is a highly optimized bone structure with unified structure and function. Shipov et al [ 18 ] found that elastic modulus in the cortical bone of OP group was less than normal group. Previous studies reported that changes in bone micro—structure is associated with the bone strength [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The role of microscopic properties on cortical bone strength of femoral neck

Xia¹,

Cai

Kan

et al. 2023

BMC Musculoskelet Disord

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Background Femoral neck fractures are serious consequence of osteoporosis (OP), numbers of people are working on the micro—mechanisms of femoral neck fractures. This study aims to investigate the role and weight of microscopic properties on femoral neck maximum load (Lmax), funding the indicator which effects Lmax most. Methods A total of 115 patients were recruited from January 2018 to December 2020. Femoral neck samples were collected during the total hip replacement surgery. Femoral neck Lmax, micro—structure, micro—mechanical properties, micro—chemical composition were all measured and analyzed. Multiple linear regression analyses were performed to identify significant factors that affected the femoral neck Lmax. Results The Lmax, cortical bone mineral density (cBMD), cortical bone thickness (Ct. Th), elastic modulus, hardness and collagen cross—linking ratio were all significantly decreased, whereas other parameters were significantly increased during the progression of OP (P < 0.05). In micro—mechanical properties, elastic modulus has the strongest correlation with Lmax (P < 0.05). The cBMD has the strongest association with Lmax in micro—structure (P < 0.05). In micro—chemical composition, crystal size has the strongest correlation with Lmax (P < 0.05). Multiple linear regression analysis showed that elastic modulus was most strongly related to Lmax (β = 0.920, P = 0.000). Conclusions Compared with other parameters, elastic modulus has the greatest influence on Lmax. Evaluation of microscopic parameters on femoral neck cortical bone can clarify the effects of microscopic properties on Lmax, providing a theoretical basis for the femoral neck OP and fragility fractures.

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The influence of estrogen deficiency on the structural and mechanical properties of rat cortical bone

Cited by 2 publications

References 40 publications

The Uses of Anabolic Androgenic Steroids Among Athletes; Its Positive and Negative Aspects- A Literature Review

The Uses of Anabolic Androgenic Steroids Among Athletes; Its Positive and Negative Aspects- A Literature Review

The role of microscopic properties on cortical bone strength of femoral neck

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