The influence of ethanol on superdisintegrants and on tablets disintegration

Bisharat, Lorina; AlKhatib, Hatim S.; Muhaissen, Suha Al; Quodbach, Julian; Blaibleh, Anaheed; Cespi, Marco; Berardi, Alberto

doi:10.1016/j.ejps.2019.01.004

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…The test conditions have also been shown to influence the disintegration and dissolution rates. Bisharat et al (2019) investigated the role of ethanol on disintegrant efficiency, whilst Zhao and Augsburger (2005) explored the role of pH of the disintegrating medium. The disintegration process is also affected by the choice of dissolution medium (e.g.…”

Section: Introductionmentioning

confidence: 99%

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Maclean

Walsh

Soundaranathan

et al. 2021

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Maclean

Walsh

Soundaranathan

et al. 2021

International Journal of Pharmaceutics

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“…The disintegration time of the tablet was determined using a jar test apparatus according to an established pharmaceutical method with some modifications to suit corrosion inhibition application [ 30 ]. 1 M HCl was used as the dissolution medium to represent actual corrosion application.…”

Section: Methodsmentioning

confidence: 99%

“…The dissolution profile of EFB-H tablet was analyzed using a jar test apparatus, referring to a typical method for pharmaceutical tablets with some alterations to suit corrosion inhibition application [ 30 ]. Initially, a pre-weighed EFB-H tablet was placed in a mesh and positioned inside a beaker containing 500 mL of disintegration medium (1 M HCl).…”

Section: Methodsmentioning

confidence: 99%

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

et al. 2021

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This study aims to develop a controlled release oil palm empty fruit bunch hemicellulose (EFB-H) inhibitor tablet for mild steel in 1 M HCl. As plant extracts tend to deteriorate at longer immersion time, limiting its industrial applicability, we attempted to lengthen the inhibition time by forming a controlled release inhibitor tablet. Electrochemical methods (potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS)) were employed to investigate the efficiency and mechanism of the inhibition. An optimum dosage and immersion time was determined via Response Surface Methodology (RSM). EFB-H tablet was formulated using D-optimal mixture design, and its anticorrosion action at extended immersion time was compared with EFB-H powder. PDP measurement revealed that EFB-H is a mixed type inhibitor. RSM optimization unveiled that the optimum point for a maximum inhibition efficiency (87.11%) was at 0.33 g of EFB-H and 120 h of immersion time. Tablet T3 with EFB-H to gum Arabic to hydroxypropyl methylcellulose ratio of 66:0:34 portrayed the best tensile strength (0.243 MPa), disintegration time (152 min) and dissolution behavior. EFB-H tablet exhibited a longer-lasting inhibition effect than powder, which was 360 h as compared to 120 h for powder. Overall, EFB-H tablet has been successfully developed, and its enhanced effective inhibition time has been experimentally proven.

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“…The volumetric swelling of tablets was measured by taking pictures of the tablets using a USB-microscope and analyzing the collected images with an image analysis software. A technique previously developed to study the disintegration of immediate-release tablets was adapted here to study tablet swelling [23,24,25].…”

Section: Methodsmentioning

confidence: 99%

Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

et al. 2019

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Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets. All throughout the study the behavior of zein was benchmarked against that of hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC). Tablets containing either zein, HPMC, or EC alone or in combination with co-excipients, namely lactose, dicalcium phosphate (DCP), microcrystalline cellulose (MCC), polyvinylpyrrolidone (PVP), or sodium lauryl sulfate (SLS) were prepared by direct compression. Matrix swelling was studied by taking continuous pictures of the tablets over 20 h, using a USB microscope connected to a PC. The overall size change and the axial and radial expansion of the tablets were automatically extrapolated from the pictures by image analysis. Moreover, drug release from tablets containing ternary mixtures of zein, co-excipients and 10% propranolol HCl was also studied. Results showed that zein matrices swelled rapidly at first, but then a plateau was reached, resulting in an initial rapid drug burst followed by slow drug release. HPMC tablets swelled to a greater extent and more gradually, providing a more constant drug release rate. EC did not practically swell, giving a nearly constant drug release pattern. Among the additives studied, only MCC increased the swelling of zein up to nearly three-fold, and thus suppressed drug burst from zein matrices and provided a nearly constant drug release over the test duration. Overall, the incorporation of co-excipients influenced the swelling behavior of zein to a greater extent compared to that of HPMC and EC, indicating that the molecular interactions of zein and additives are clearly more complex and distinct.

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The influence of ethanol on superdisintegrants and on tablets disintegration

Cited by 19 publications

References 25 publications

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

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