The influence of ethnicity on the characteristics of multiple sclerosis: A local population study between Persians and Arabs

Sharafaddinzadeh, Naser; Moghtaderi, Ali; Majdinasab, Nastaran; Dahmardeh, Maryam; Kashipazha, Davood; Shalbafan, Bita

doi:10.1016/j.clineuro.2012.11.027

Cited by 36 publications

(23 citation statements)

References 28 publications

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“…However, the prevalence of advanced stages of MS with brain and motor symptoms is higher among Arab ethnic groups (24). The findings of no significant differences between Arab and non-Arab ethnic groups in the present study imply that there was no significant association of Arab ethnicity with the risk of MS.…”

Section: Discussioncontrasting

confidence: 52%

“…A number of studies have examined some demographic characteristics and risk of MS. A study in Brazil showed that marital status is associated with MS (14), although a Canadian study did not show a connection between marital status and MS (21). A number of studies also examined the relationships between MS and ethnicity, place of residence for the first 15 years of life, and marriage (14,(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

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Multiple Sclerosis and Several Demographic Characteristics, Family History of MS, and Month of Birth: A Case-Control Study

Bagheri

Fayazi

Elahi

et al. 2015

Jentashapir J Health Res

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Background: Several factors have been reported as risk factors for multiple sclerosis (MS); however, the main causes of the disease are still unknown. A geographical area with a low MS incidence is Ahvaz, Iran. Objectives: The objective of this study was to evaluate the association of several demographic characteristics, family history, and birth month with MS in Ahvaz. Patients and Methods:This was a case-control study including 155 MS cases and 155 controls matched for age, sex, and residential status. The participants were selected randomly, using a systematic method, from the MS patients referred to the MS Society of Khuzestan (Iran). The data collection tool was a standardized questionnaire designed by the authors to assess demographic characteristics. Data were analyzed using descriptive statistics including mean, frequency, and standard deviation and inferential statistical tests including χ 2 , Fisher's exact test, and logistic regression using SPSS version 19. Results: In both cases and controls, no significant associations were found between Arab ethnicity and incidence of MS, marital status and risk of MS in Ahvaz, or more than 15-year residency in Ahvaz, birth in Khuzestan, and month of birth and the risk of MS (P > 0.05). However, there was a marginally significant association between living from birth to age 15 years in Ahvaz and MS (P = 0.05). Furthermore, there was an association between a family history of MS and the risk of MS in Ahvaz (P = 0.02), which was significant in univariate logistic regression (P = 0.006). Conclusions:The findings suggested that according to the ecological conditions of Ahvaz, a family history of MS may increase the risk of developing MS.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Multiple Sclerosis and Several Demographic Characteristics, Family History of MS, and Month of Birth: A Case-Control Study

Bagheri

Fayazi

Elahi

et al. 2015

Jentashapir J Health Res

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“…Of these, the following were excluded: 5 that reported the prevalence of MS among Iranian immigrants, 4 case reports, and 2 without prevalence and clinical patterns. Hence, 11 studies were included, published from 2006 to 2013 [10,11,12,13,14,15,16,17,18,19,20]. …”

Section: Resultsmentioning

confidence: 99%

Epidemiology of Multiple Sclerosis in Iran: A Systematic Review

Etemadifar¹,

Sajjadi²,

Nasr³

et al. 2013

Eur Neurol

160

105

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Background: There is a wide variation in the prevalence of multiple sclerosis (MS) in different geographical regions and the epidemiology of MS in Iran has been a major topic of concern during the last decade. Several population-based studies have shown a sharp increase in the prevalence and incidence of MS in this region. In this study, for the first time, the aim was to provide a comprehensive review regarding the incidence and prevalence of MS across Iran. Methods: A comprehensive literature search was performed using PubMed, Embase, and Web of Science. We also did a manual search of reference lists from primary articles and relevant reviews. Databases of ongoing research and unpublished literature were also searched. Results: A total of 22 relevant studies were reviewed and 11 studies met the inclusion criteria. Incidence data were found in 5 studies and ranged from 0.68 to 9.1/100,000 per year in the Iranian population. Prevalence was reported in all studies and ranged from 5.3 to 74.28/100,000 with the higher prevalence among females (female/male ratio ranged from 1.8 to 3.6). The most prevalent subtype of MS was the relapsing-remitting form (65.8-87.8%). The sensory disturbance was the most initial presentation. Conclusion: The incidence and prevalence of MS in Iran has been increasing rapidly, especially in females. Future research should focus on determining the epidemiological features of MS in the neglected provinces with different ethnicities. Such an effort along with further research towards improvement of data on previously studied areas can enable a field to be opened up to identify the patterns of MS in varied genetic backgrounds and environments of Iran.

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“…Based on the recent study that was carried out by Sharafaddinzadeh et al MS incidence and prevalence are less among Arabs comparing Persian population in Khuzestan province [29], that is because we calculated the possible association between HLA-DRB1*1501 with Persians and Arabs, separately. According to frequency of the mentioned allele in Persians and Arabs population, significant association in either Persians or Arabs comparing control group was observed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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Background: Multiple sclerosis (MS) is a demyelinating, autoimmune and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. The contribution of HLA-DRB1*1501 to MS risk has been replicated and confirmed in most population-based studies. Since there are no data with respect to the association of HLA-DRB1*1501 and MS in Khuzestan province. Objectives: The aim of this study was to investigate the correlation of this allele with MS in Khuzestan province. Methods: In this case-control study, DRB1*1501 allele was analyzed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 200 MS patients and 200 unrelated healthy individuals, without any autoimmune disease from the same geographical region. The frequencies of the mentioned allele were compared between the patients and control group using SPSS 16 statistical software and the chi square test. Results:The results demonstrated that distribution of DRB1*1501 allele was statistically different between patient and control (41.5% vs. 22.81%, P < 0.001); significant correlation was observed among these allele with both Arab (28.84% vs. 50.84%, P = 0.005) and Persian (15.87% vs. 35.55%, P = 0.018) ethnicities; although no association was revealed between mentioned allele and disease clinical course (relapsing-remitting, secondary-progressive, progressive-relapsing and primary-progressive), expanded disability scale score (EDSS) and gender. Conclusions:The study presents association of susceptibility to multiple sclerosis in southwest of Iran with HLA-DRB1*1501 allele in both Arab and Persian ethnic; although DRB1*1501 may be is not involved in the pathogenesis of different MS disease subtypes. The results are consistent with most of the other studies in Iran; and also most studies in European populations.

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The influence of ethnicity on the characteristics of multiple sclerosis: A local population study between Persians and Arabs

Cited by 36 publications

References 28 publications

Multiple Sclerosis and Several Demographic Characteristics, Family History of MS, and Month of Birth: A Case-Control Study

Multiple Sclerosis and Several Demographic Characteristics, Family History of MS, and Month of Birth: A Case-Control Study

Epidemiology of Multiple Sclerosis in Iran: A Systematic Review

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

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