The Influence of Exercise on Cancer Risk, the Tumor Microenvironment and the Treatment of Cancer

He, Anqi; Pu, Yamin; Jia, Chengsen; Wu, Mengling; He, Hongchen; Xia, Yong

doi:10.1007/s40279-024-02031-2

Cited by 3 publications

(1 citation statement)

References 142 publications

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“…Increasing evidence suggests that exercise triggers immune infiltration and partially alleviates immunosuppressive metabolites as well as enhances immunogenicity [18]. While prehabilitation exercise protocols are hard to track because of their diversity and applicability in different patient populations, they might be an important complementary intervention in cancer care.…”

Section: Modifiable Factors 211 Value Of Prehabilitation Programs In ...mentioning

confidence: 99%

Perioperative Immunosuppressive Factors during Cancer Surgery: An Updated Review

Bezu,

Akçal Öksüz,

Bell

et al. 2024

Cancers

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Surgical excision of the primary tumor represents the most frequent and curative procedure for solid malignancies. Compelling evidence suggests that, despite its beneficial effects, surgery may impair immunosurveillance by triggering an immunosuppressive inflammatory stress response and favor recurrence by stimulating minimal residual disease. In addition, many factors interfere with the immune effectors before and after cancer procedures, such as malnutrition, anemia, or subsequent transfusion. Thus, the perioperative period plays a key role in determining oncological outcomes and represents a short phase to circumvent anesthetic and surgical deleterious factors by supporting the immune system through the use of synergistic pharmacological and non-pharmacological approaches. In line with this, accumulating studies indicate that anesthetic agents could drive both protumor or antitumor signaling pathways during or after cancer surgery. While preclinical investigations focusing on anesthetics’ impact on the behavior of cancer cells are quite convincing, limited clinical trials studying the consequences on survival and recurrences remain inconclusive. Herein, we highlight the main factors occurring during the perioperative period of cancer surgery and their potential impact on immunomodulation and cancer progression. We also discuss patient management prior to and during surgery, taking into consideration the latest advances in the literature.

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Section: Modifiable Factors 211 Value Of Prehabilitation Programs In ...mentioning

confidence: 99%

Perioperative Immunosuppressive Factors during Cancer Surgery: An Updated Review

Bezu,

Akçal Öksüz,

Bell

et al. 2024

Cancers

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Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit?

Maroni,

Gomarasca,

Signo

et al. 2024

Advanced Exercise and Health Science

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Acute effects of high-intensity interval training on microvascular circulation: a case control study in uveal melanoma

Mendes Wefelnberg,

Hubert,

Baumann

et al. 2024

Translational Exercise Biomedicine

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Objectives The aim of this study was to explore the acute effects of high-intensity interval training (HIIT) on the microvascular circulation and vascular tumor microenvironment (TME) in a patient with uveal melanoma (UM). Additionally, the acceptance of the applied diagnostics and the exercise protocol in a clinical ophthalmic-oncology setting were evaluated. Methods This case-control study included a young adult male patient with UM previously treated with radiation and an age-matched healthy control. Participants underwent a baseline assessment of dynamic retinal vessel analysis (DRVA) and cardiopulmonary exercise testing (CPET) to determine endothelial function and intensity for HIIT. Optical coherences tomography angiography (OCTA) was performed before, immediately and 30 min after one session of HIIT. The primary outcome were changes in ocular vessel parameters and whole body oxygen uptake. Results The UM patient exhibited lower arterial dilation and constriction in the affected eye compared to his healthy eye and both eyes of the healthy control. OCTA revealed heterogeneous patterns of vascular response to HIIT in both participants. The tumor eye showed an increase followed by a significant decrease in vessel density post-exercise, while the healthy control exhibited minor increases. Conclusions The findings of this study highlighted the potential of UM combined with OCTA and DRVA as a model for examine exercise-induced vascular effects within the TME. However, a pre-treated UM as well as detailed image analyses and further research with longitudinal, randomized controlled designs are essential to validate these findings and address methodological limitations. Such investigations could refine integrative cancer treatment.

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The Influence of Exercise on Cancer Risk, the Tumor Microenvironment and the Treatment of Cancer

Cited by 3 publications

References 142 publications

Perioperative Immunosuppressive Factors during Cancer Surgery: An Updated Review

Perioperative Immunosuppressive Factors during Cancer Surgery: An Updated Review

Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit?

Acute effects of high-intensity interval training on microvascular circulation: a case control study in uveal melanoma

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