Few efforts have attempted to model the tribological interaction of shoe-floor contacting surfaces despite high prevalence of slipping accidents. Hysteresis and adhesion are the two main contributing mechanisms in shoe-floor friction at the microscopic asperity level. This study developed a three-dimensional microscopic finite element model of shoe-floor surfaces to quantify the effect of surface topography, shoe material properties and sliding speed on hysteresis and adhesion friction. The validity of the model was assessed by comparing model predictions to pin-on-disk experimental data. The model predicts that hysteresis friction increases for harder shoe materials, rougher shoe surfaces and rougher floor surfaces, while adhesion increases for smoother shoe surfaces, smoother floor surfaces and decreasing sliding speed. The effects of shoe material and floor roughness on the predicted hysteresis friction values were consistent with the experimental data. The effects of sliding speed on adhesion friction were moderately consistent with the experimental data. In addition, the predicted hysteresis magnitudes were consistent with experimental data. This model is a significant step toward development of a comprehensive shoefloor friction model.