The influence of habitual breaks in sedentary time on cardiovagal baroreflex function

O’Brien, Myles W.; Al-Hinnawi, Amera; Wu, Yanlin; Petterson, Jennifer L.; Shivgulam, Madeline E.; Johns, Jarrett A.; Frayne, Ryan J.; Kimmerly, Derek S.

doi:10.1139/apnm-2021-0246

Cited by 13 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some activPAL data have been previously published in a sub-sample of 73 (37 females) that evaluated the impact of habitual activity on peripheral vascular function 14 and the influence of sedentary activity on baroreflex sensitivity. 15 However, the current purpose and statistical analyses (i.e., comparison with aerobic fitness) are independent from these previous reports. Based on a moderate-large effect size ( f 2 = 0.25) and 5 predictor variables (sedentary time, standing time, LPA, MPA and VPA), a sample size calculation estimated that a minimum of 58 participants were needed assuming a two-tailed, α = 0.05 and β = 80% power (G∗Power, v3.1 16 ).…”

Section: Methodsmentioning

confidence: 92%

“…ActivPAL data were analyzed using a customized LabVIEW program (LabVIEW 2013; National Instruments, Austin, TX, USA) that confirmed waking hours and summarized daily averages of time spent awake, standing, sitting/lying down. 15 This program also reported the number and duration of various sedentary patterns (i.e., total time spent in bouts > 60 min and the number sedentary breaks/waking hour). 15 Physical activity intensity (LPA, MPA, VPA) was determined using step rate thresholds that were determined using cross-validated curvilinear cadence-intensity equations individualized for height (younger adults) or body mass index (older adults) that are more accurate than the default activPAL settings in determining physical activity intensity.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Habitual sedentary time and stationary time are inversely related to aerobic fitness

O’Brien¹,

Shivgulam²,

Petterson³

et al. 2022

Sports Medicine and Health Science

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Habitual sedentary time and stationary time are inversely related to aerobic fitness

O’Brien¹,

Shivgulam²,

Petterson³

et al. 2022

Sports Medicine and Health Science

Self Cite

View full text Add to dashboard Cite

“…Participants’ activPAL™ data have been previously presented. 8 However, the current purpose and statistical analyses were independent from this previous report, which did not examine peripheral vascular function. Prior to testing, verbal and written informed consent were acquired.…”

Section: Methodsmentioning

confidence: 96%

“… 3 Existing research in laboratory settings have demonstrated that acute bouts of prolonged sitting (i.e., ⩾ 3 h) attenuate lower-limb FMD responses. 4 – 6 Furthermore, Thosar et al 5 demonstrated that periodically breaking up an uninterrupted bout of sitting preserved FMD. Although these studies have provided insight into the vascular implications following a single bout of sitting in lab-based settings only, our understanding regarding the impact of habitual sedentary time or patterns on popliteal endothelial health in a free-living environment is unknown.…”

Section: Introductionmentioning

confidence: 99%

Impact of habitual sedentary patterns on popliteal artery endothelial-dependent vasodilation in healthy adults

et al. 2022

Self Cite

View full text Add to dashboard Cite

Introduction: Acute, laboratory-based bouts of prolonged sitting attenuate lower-limb arterial endothelial-dependent vasodilation. However, the impact of habitual sedentary patterns on popliteal artery endothelial health is unclear. We tested the hypothesis that greater habitual total sedentary time, more time spent in prolonged sedentary bouts, and fewer sedentary breaks would be associated with worse popliteal flow-mediated dilation (FMD) responses. Methods: This cross-sectional study used 98 healthy participants (19–77 years, 53 females) that wore an activPAL monitor on the thigh for 6.4 ± 0.8 days to objectively measure sedentary activity and completed a popliteal ultrasound assessment to determine FMD. Both relative (%baseline diameter) and absolute (mm) FMD were calculated. Using bivariate correlation and multiple regression analyses, we examined if there were relationships between sedentary outcomes and FMD while statistically controlling for any potential confounders. Results: In the multiple regression model, age ( p = 0.006, β = −0.030, 95% CI = −0.051, −0.009) and total time in sedentary bouts > 1 hour ( p = 0.031, β = −0.005, 95% CI = −0.009, −0.001) were independent predictors of relative FMD. Age (β = −0.002, 95% CI = −0.003, −0.001), mean blood flow (β = 0.013, 95% CI = 0.002, 0.024), moderate-intensity physical activity (β = 155.9E−5, 95% CI = 22.4E−5, 289.4E−5), sedentary breaks (β = 0.036, 95% CI = 0.007, 0.066), and total time spent in sedentary bouts > 1 hour (β = −25.02E−5, 95% CI = −47.67E−5, −2.378E−5) were predictors of absolute FMD (all, p < 0.047). All independent outcomes remained significant after partially controlling for all other predictor variables (all, p < 0.031). Conclusions: Habitual prolonged sedentary bouts and sedentary breaks, but not total sedentary time, were predictors of popliteal endothelial-dependent vasodilatory function. The patterns by which sedentary time is accumulated may be more important than the total sedentary time on lower-limb arterial health.

show abstract

“…We compiled habitual thigh-worn activPAL™ (activPAL3; PAL Technologies Ltd., Glasgow, UK) data. ActivPAL data have been previously reported (10). However, the purpose and analysis presented is unique to the current study.…”

Section: Methods Participantsmentioning

confidence: 95%

Ecological Validity of Prolonged Sitting Studies: How Well Do They Represent Real-Life Sedentary Patterns? A Pilot Study

O’Brien

Petterson

et al. 2021

Transl J ACSM

Self Cite

View full text Add to dashboard Cite

Acute prolonged sitting studies have been frequently implemented to determine the physiological effect of sedentary time on vascular and metabolic health. The length of these laboratory-based prolonged sitting studies ranges from 1.5 to 6 h, with most being 3 h in duration. Whether or not these sitting durations reflect true habitual prolonged sitting patterns is unclear. The purpose of this pilot study was to examine the habitual sedentary patterns of a heterogeneous sample to inform the design of future acute laboratory-based sitting studies. Participants (n = 121; 48 females) wore an activPAL inclinometer on their thigh 24 h•d −1 for 6.5 ± 0.7 d. A customized LabVIEW program determined daily averages of waking hours spent standing versus sitting and/or laying. The number of prolonged sedentary bouts (e.g., number of sedentary bouts >30 min) and the frequency of sedentary breaks (per waking hour) were also calculated. Overall, participants engaged in 9.4 ± 1.9 h•d −1 of sedentary time. Participants frequently engaged in sedentary bouts between 0.5 and 1.0 h (3.5 ± 1.1 bouts per day) and between 1 and 2 h (1.7 ± 0.8 bouts per day) in duration. By contrast, they rarely engaged in bouts >2 h without interruption (i.e., once every ~5 d). Very few participants engaged in any prolonged sedentary bouts between 3 and 4 h (n = 25; 21%) or >4 h (n = 6, 5%). Participants averaged 2.9 ± 0.7 sedentary breaks per hour (i.e., every ~21 min), with the majority (n = 83, 69%) breaking up their sitting time every 17-30 min (i.e., 2-3.5 breaks per hour). To maximize the ecological validity, our preliminary findings indicate that acute models of prolonged sitting should be 1-2 h in length and strategies to break up prolonged sitting implemented every 20-30 min. The results from this pilot study may be used to inform large epidemiological studies to characterize prolonged sitting patterns in a variety of populations to assist in translating findings from the laboratory to the habitual setting.

show abstract

The influence of habitual breaks in sedentary time on cardiovagal baroreflex function

Cited by 13 publications

References 11 publications

Habitual sedentary time and stationary time are inversely related to aerobic fitness

Habitual sedentary time and stationary time are inversely related to aerobic fitness

Impact of habitual sedentary patterns on popliteal artery endothelial-dependent vasodilation in healthy adults

Ecological Validity of Prolonged Sitting Studies: How Well Do They Represent Real-Life Sedentary Patterns? A Pilot Study

Contact Info

Product

Resources

About