The influence of high-dose simvastatin and diltiazem on myocardium in rabbits: a haemodynamic study

Jasińska, Magdalena; Owczarek, Jacek; Orszulak–Michalak, Daria

doi:10.5114/aoms.2011.23401

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Among the parameters used to verify myonecrosis, the CK level is commonly used in the diagnosis of myopathies [60][61][62][63]. In the experimental control and laser groups (p N 0.05), no changes were found in serum CK levels.…”

Section: Discussionmentioning

confidence: 99%

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Pissulin¹,

Fernandes

Orellana

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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Section: Discussionmentioning

confidence: 99%

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Pissulin¹,

Fernandes

Orellana

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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“…This may suggest another mechanism of drug-drug interaction than the one based on CYP3A4 inhibition (63).…”

Section: Major Statin-drug Interactionsmentioning

confidence: 95%

Drug interactions with statins

Causevic-Ramosevac¹,

Semiz²

2013

Acta Pharmaceutica

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All important drug interactions, with the possible exception of idiosyncratic or allergic reactions, have a pharmacokinetic or pharmacodynamic basis, or both (1). A study of the mechanisms of drug interactions is of much value in selecting proper drug combinations in order to provide rational therapy, especially for drugs that have a narrow margin of safety and where drugs are used for a prolonged period of time. Most recently, pharmacogenetics has linked drug interaction outcomes to variations in genes encoding cytochrome P450 (CYP) enzymes (2) and transporter genes.Statins (or HMG-CoA reductase inhibitors) represent a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. As of 2010, a number of statins have been on the market: atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin (3).Statins are associated with two uncommon, but important, adverse effects, asymptomatic elevation in liver enzyme activity and myopathy. In 2001, cerivastatin was withdrawn from the market worldwide because of an unacceptably high incidence of serious The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT--P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.

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“…Normal cTnI concentration in healthy rabbits ranges from 0.012 to 0.014 ng/dL (16). As the reagent concentrations in the immunochromatographic test exceeded 0.5 ng/mL, it is possible to infer the occurrence of myocardial injury with low-level cTnI release.…”

Section: Nonementioning

confidence: 99%

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Borboleta¹,

Ef²,

Oliveira³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Clinical and laboratory changes were evaluated in rabbits after intoxication by Amorimia rigida, a plant that causes sudden death. Nine New Zealand male rabbits, averaging 3.54 kg, were categorized into three groups (n = 3) and received, for eight consecutive days, the equivalent of 30 g/kg dry matter of A. rigida water-soluble (SG) and water-insoluble (IG) extracts via nasoesophageal route. The control group received water. There were no alterations in creatine kinase enzyme (CK), CK myocardial fraction (CKMB) or troponine I (cTnI). None of the animals had clinical or electrocardiographic (conventional and Holter) alterations. There were progressive decreases in the left ventricular ejection fraction and systolic fractional shortening. Doppler echocardiography alterations suggested a systolic dysfunction in the SG and IG groups and diastolic dysfunction in IG group. It was concluded that the soluble and insoluble extracts of A. rigida cause deficit of cardiac function.Key words: toxic plant, Amorimia rigida, cardiac muscle profile, electrocardiography, echocardiography, rabbit. Original PaPer The Journal of Venomous Animals and Toxins including Tropical Diseases ISSN 1678-9199 | 2012 | volume 18 | issue 3 | pages 295-305 INTRODUCTIONThe genus Amorimia (Malpighiaceae) contains one of the 10 most important toxic plants in South America (1), best known of which is Amorimia rigida (Mascagnia rigida), well distributed in Minas Gerais state (Brazil), mainly in the northern and northeastern regions, where it is popularly known as "salsa-rosa" or "suma-roxa". It belongs to a group that causes acute intoxication that may provoke death preceded or not by a short period of clinical signs (2).After A. rigida intake, animals may show apathy, anorexia, rigid walking, prolonged recumbence, muscle tremors and death, among other clinical signs. Significant alterations have not been found at necropsy of animals intoxicated by A. rigida. Multifocal infiltrate of lymphocytes in the myocardium associated with edema and congestion of myocytes was found in the histological exams (3).Studies are necessary to elucidate which physiopathological mechanisms are involved in A. rigida intoxication that leads to sudden death. In spite of the existence of some reports of mortality in the absence of cardiac lesions, it is suggested that the main action of this plant in the heart may be due to its phytochemical characteristics that might affect cardiac function within a period insufficient to produce alterations detectable by optical microscopy (4).To the best of our knowledge, no previous study has concurrently evaluated continuous electrocardiography (Holter), Doppler echocardiography and the cardiac muscle biochemical profile in animals after the intake of A. rigida. Thus, the present work aimed to ascertain the influence of this plant on the cardiac system using the rabbit as the experimental model. MATERIALS AND METHODS Animal AssaysNine six-month-old white New Zealand male rabbits weighing an average of 3.54 kg were used. Firstl...

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The influence of high-dose simvastatin and diltiazem on myocardium in rabbits: a haemodynamic study

Cited by 4 publications

References 23 publications

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Drug interactions with statins

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

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