The influence of hydroxy propyl β-cyclodextrin on the micellar to gel transition in F127 solutions investigated at macro and nanoscale levels

Micutz, Marin; Matalon, Erez; Staicu, Teodora; Angelescu, Daniel G.; Ariciu, Ana-Maria; Rogozea, Elena Adina; Turcu, Ioana Maria; Ioniţă, Gabriela

doi:10.1039/c4nj00123k

Cited by 12 publications

(22 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To exemplify, Figure shows the fluorescence spectra of Py(EG) 3 at 293 K in water, in HPB solutions and in F127 systems 1–3. In the previous study we also noticed that the dual molecular probe DT (Figure S2, Supporting Information) sensed a more hydrophobic environment in F127 systems as compared to the cyclodextrin cavity. The hypsochromic shift in the presence of cyclodextrin is larger for DT compared to the probes containing pyrene as fluorophore, due to the higher affinity of the dansyl moiety for the cyclodextrin cavity.…”

Section: Resultsmentioning

confidence: 60%

“…The systems presented in Table and used in this paper have been characterized in a previous study, where we have shown that HPB narrows the gel temperature interval of F127, increases the micelle‐to‐gel transition temperature, and decreases the gel strength . The previous study used two pluronic spin probes, a spin‐labeled cyclodextrin, and a dual dansyl‐TEMPO molecular probe.…”

Section: Resultsmentioning

confidence: 99%

“…The F127 systems investigated in this study were previously characterized macroscopically by dynamic rheometry and the tube inversion method (Figure S1, Supporting Information), in order to obtain the temperature corresponding to the transition from micelle to gel ( Table 1 ). Using polymeric spin probes and the dansyl‐TEMPO (DT) dual molecular probe, we highlighted that macroscopic data can be correlated with changes observed at microscopic level during the micelle‐to‐gel transition. Both pluronic F127 and HPB are used in drug formulations.…”

Section: Introductionmentioning

confidence: 98%

“…Steady‐state fluorescence spectroscopy has been used for decades to establish the micelle formation in pluronic systems using pyrene as a molecular probe . This probe is also sensitive to micelle‐to‐gel transition in pluronic systems . Similarly, other fluorescent probes such as coumarin derivatives bearing a long alkyl chain have been used to report on the micelle‐to‐gel transition in triblock‐copolymer systems including F127 as a function of concentration and temperature.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

Baratoiu

Mocanu

Matei

et al. 2019

Macro Chemistry & Physics

Self Cite

View full text Add to dashboard Cite

Molecular probes are often used to describe local interactions and to characterize inhomogeneities in complex systems. In this study, two series of monomolecular probes (paramagnetic or fluorescent) and a series of dual molecular probes are used to evaluate local changes and the regions targeted by these probes in three pluronic F127 systems, in the absence and in the presence of 2‐hydroxypropyl‐β‐cyclodextrin, which have been previously characterized. All molecular probes used in this study have as a common structural unit the short oligoethylene chains that link (2,2,6,6‐Tetramethylpiperidin‐1‐yl)oxyl (TEMPO) and/or pyrene moieties. Using these probes, changes in hydrophobicity inside the pluronic micelles are evidenced and the micelle‐to‐gel phase transition is characterized.

show abstract

Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

Baratoiu

Mocanu

Matei

et al. 2019

Macro Chemistry & Physics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The thermo-responsive hydrogels of various polymeric structures have been studied by EPR spectroscopy using the spin probe method. Some examples are thermo-responsive poly(N-isopropylacrylamide) hydrogels [16], gelatin gels [17] and pluronic F127 [18].…”

Section: Introductionmentioning

confidence: 99%

Investigations on Carboxy Dibenzylidene Sorbitol Hydrogels Using EPR Spectroscopy

et al. 2015

Self Cite

View full text Add to dashboard Cite

Low-molecular-weight organic gelators generate physical gels by the formation of three-dimensional fibrous network structures as a response to various physicochemical stimuli such as heat, light, ultrasound and chemical environments. Dibenzylidene sorbitol (DBS) represents a typical compound able to generate gels because of some prerequisite structural features: the presence of functional groups to form intermolecular hydrogen bonds and of aromatic groups to be involved in p-p interactions, or chirality. Herein, we present the synthesis of three derivatives of DBS-bearing carboxy groups attached to phenyl rings and the corresponding spin-labelled compounds. We studied the formation of physical gels resulting from self-assembly of DBS derivatives with the aim of highlighting the influence of the position of the carboxy group on the gel properties. These types of compounds can form gels in polar solvents (such as water, DMSO) by either temperature treatment or variation of the pH. In this study, the systems were investigated by rheological measurements, SEM analysis and EPR measurements. The results showed that the introduction of carboxy groups into the structure of DBS generates weaker gels compared with the parent gelator, DBS. The spin probes used in this study (spinlabelled DBS derivatives and 5-doxyl stearic acid) demonstrated that assembly of gelator molecules is a highly selective process. The two-component feature of EPR

show abstract

New environment-sensitive bis-dansyl molecular probes bearing alkyl diamine linkers: Emissive features and interaction with cyclodextrins

Mocanu

Ioniţă

Ionescu

et al. 2018

Chemical Physics Letters

View full text Add to dashboard Cite

The influence of hydroxy propyl β-cyclodextrin on the micellar to gel transition in F127 solutions investigated at macro and nanoscale levels

Cited by 12 publications

References 65 publications

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

Investigations on Carboxy Dibenzylidene Sorbitol Hydrogels Using EPR Spectroscopy

New environment-sensitive bis-dansyl molecular probes bearing alkyl diamine linkers: Emissive features and interaction with cyclodextrins

Contact Info

Product

Resources

About