The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers

Kolbitsch, Christian; Lorenz, Ingo; Hörmann, Christoph; Hinteregger, Martin; Löckinger, Alexander; Moser, Patrizia; Kremser, Christian; Schocke, Michael; Felber, Stephan; Pfeiffer, Karl P.; Benzer, A.

doi:10.1016/s0730-725x(02)00534-9

Cited by 36 publications

(41 citation statements)

References 33 publications

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“…Even within GM, the hyperoxic induced vasoconstriction depends on regions. For example, hyperoxia diminished CBF in all regions except in parietal and left hemispheric frontal GM [23]. In contrary to inducing of vasoconstriction, hyperoxia can stimulate vasculogenic stem cell growth and differentiation in vivo [52].…”

Section: Discussionmentioning

confidence: 94%

Structural Modulation of Brain Development by Oxygen: Evidence on Adolescents Migrating from High Altitude to Sea Level Environment

Zhang

Chen

et al. 2013

PLoS ONE

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The present study aimed to investigate structural modulation of brain by high level of oxygen during its peak period of development. Voxel-based morphometry analysis of gray matter (GM) and white matter (WM) volumes and Tract-Based Spatial Statistics analysis of WM fractional anisotropy (FA) and mean diffusion (MD) based on MRI images were carried out on 21 Tibetan adolencents (15–18 years), who were born and raised in Qinghai-Tibetan Plateau (2900–4700 m) and have lived at sea level (SL) in the last 4 years. The control group consisted of matched Tibetan adolescents born and raised at high altitude all the time. SL immigrants had increased GM volume in the left insula, left inferior parietal gyrus, and right superior parietal gyrus and decreased GM in the left precentral cortex and multiple sites in cerebellar cortex (left lobule 8, bilateral lobule 6 and crus 1/2). Decreased WM volume was found in the right superior frontal gyrus in SL immigrants. SL immigrants had higher FA and lower MD at multiple sites of WM tracts. Moreover, we detected changes in ventilation and circulation. GM volume in cerebellum lobule 8 positively correlated with diastolic pressure, while GM volume in insula positively correlated vital capacity and hypoxic ventilatory response. Our finding indicate that the structural modulations of GM by high level of oxygen during its peak period of development are related to respiratory and circulatory regulations, while the modulation in WM mainly exhibits an enhancement in myelin maturation.

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Section: Discussionmentioning

confidence: 94%

Structural Modulation of Brain Development by Oxygen: Evidence on Adolescents Migrating from High Altitude to Sea Level Environment

Zhang

Chen

et al. 2013

PLoS ONE

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“…Rabbits were made hypoxic by changing the ventilator gas mixture from 21% oxygen (room air) to 10% oxygen. Responses to hyperoxia come from studies by Kolbitsch et al (51) and Flemming et al (30). reductions in renal tissue PO 2 and so is a strong signal for increased erythropoietin synthesis.…”

Section: Unique Challenges For Regulation Of Kidney Oxygenationmentioning

confidence: 99%

Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis

Evans¹,

Gardiner²,

Smith³

et al. 2008

American Journal of Physiology-Renal Physiology

244

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The kidney is faced with unique challenges for oxygen regulation, both because its function requires that perfusion greatly exceeds that required to meet metabolic demand and because vascular control in the kidney is dominated by mechanisms that regulate glomerular filtration and tubular reabsorption. Because tubular sodium reabsorption accounts for most oxygen consumption (Vo2) in the kidney, renal Vo2 varies with glomerular filtration rate. This provides an intrinsic mechanism to match changes in oxygen delivery due to changes in renal blood flow (RBF) with changes in oxygen demand. Renal Vo2 is low relative to supply of oxygen, but diffusional arterial-to-venous (AV) oxygen shunting provides a mechanism by which oxygen superfluous to metabolic demand can bypass the renal microcirculation. This mechanism prevents development of tissue hyperoxia and subsequent tissue oxidation that would otherwise result from the mismatch between renal Vo2 and RBF. Recent evidence suggests that RBF-dependent changes in AV oxygen shunting may also help maintain stable tissue oxygen tension when RBF changes within the physiological range. However, AV oxygen shunting also renders the kidney susceptible to hypoxia. Given that tissue hypoxia is a hallmark of both acute renal injury and chronic renal disease, understanding the causes of tissue hypoxia is of great clinical importance. The simplistic paradigm of oxygenation depending only on the balance between local perfusion and Vo2 is inadequate to achieve this goal. To fully understand the control of renal oxygenation, we must consider a triad of factors that regulate intrarenal oxygenation: local perfusion, local Vo2, and AV oxygen shunting.

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“…As changes in CBF are very sensitive to changes in PaCO 2 it has been very difficult to distinguish the independent effect of PaO 2 on CBF without maintaining precise isocapnia. Kolbitsch et al (2002) administered both room air and F I O 2 of 1.0 (i.e., 100% inspired O 2 ) to healthy volunteers and asked them to maintain isocapnia voluntarily by constraining their P ET CO 2 to 40 mm Hg using feedback from their P ET CO 2 displayed on a screen. CBF was estimated from middle cerebral artery flow velocity as measured by transcranial Doppler (TCD) and from contrast-enhanced MRI perfusion measurements.…”

Section: Mr Responsesmentioning

confidence: 99%

“…The theoretical advantage of this approach is that BOLD and P ET O 2 can be precisely quantified, compared to HC-induced CBF changes which are measured by perfusion imaging, a method with intrinsically low signal-to-noise ratio (SNR). Increases in BOLD signal induced by HO occur through flow- (Kolbitsch et al, 2002;Reinstrup et al, 2001) and metabolism- (Sicard and Duong, 2005) independent changes in dHb. The HO-induced increase of O 2 dissolved in arterial blood plasma provides some of the O 2 requirements of the tissues, reducing the extent of desaturation of oxyhaemoglobin in the venous blood (Berkowitz, 1997;Bulte et al, 2006;Kwong et al, 1995;Rostrup et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Improved fMRI calibration: Precisely controlled hyperoxic versus hypercapnic stimuli

2011

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The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers

Cited by 36 publications

References 33 publications

Structural Modulation of Brain Development by Oxygen: Evidence on Adolescents Migrating from High Altitude to Sea Level Environment

Structural Modulation of Brain Development by Oxygen: Evidence on Adolescents Migrating from High Altitude to Sea Level Environment

Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis

Improved fMRI calibration: Precisely controlled hyperoxic versus hypercapnic stimuli

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