The Influence of Insulin on Abomasal Emptying in Cattle*

Meirhaeghe, H. van; Deprez, Piet; Hende, C. Van Den; Muylle, E.

doi:10.1111/j.1439-0442.1988.tb00025.x

Cited by 17 publications

(14 citation statements)

References 8 publications

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“…Increased insulin was observed in cases with DA (Van Meirhaeghe et al, 1988b;Pravettoni et al, 2004;Sen et al, 2006) and was implicated as a factor in the pathogenesis of DA (Van Meirhaeghe et al, 1988b;Geishauser, 1995). Van Meirhaeghe et al (1988a) observed decreases in abomasal emptying after an intravenous glucose infusion, followed by an increased secretion of endogenous insulin. The same observation was made after a bolus injection of exogenous insulin, which was followed by a decrease in plasma glucose.…”

Section: Introductionmentioning

confidence: 99%

Potassium and insulin affect the contractility of abomasal smooth muscle

Türck

Leonhard-Marek

2010

Journal of Dairy Science

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Abomasal displacement is a frequent and important disease of high yielding dairy cows. Although several factors are related to its occurrence, the pathogenesis of the condition is still inadequately understood, particularly in regard to K(+) and insulin homeostasis. For this reason the aim was to investigate the effects of K(+) and insulin concentrations on in vitro motility of abomasal smooth muscle. The second aim was to determine whether the in vivo change in K(+) and insulin levels might be sufficient to induce reduced abomasal motility. Muscle strips were isolated from the abomasum of slaughtered cows and incubated in buffer solution under isometric conditions. Results show that a decrease in extracellular K(+) (between 5 and 1 mmol/L) or an increase in extracellular insulin concentrations (to 21 mU/L or higher) were able to affect the contraction activity of abomasal muscles. Contraction activity given as median (25th, 75th percentiles) changed from 28.1 mN/min (2.5, 49.9) at 5 mmol/L of K(+) to 9.4 mN/min (0.6, 35.7) at 1 mmol/L of K(+), and from 34.5 mN/min (10.8, 112.4) at 0 mU/L of insulin to 12.0 mN/min (7.6, 49.8) at 120 mU/L of insulin. Because the effect of insulin could be abolished by barium, glybenclamide, or ouabain, the underlying mechanisms of the insulin action could be an increased K(+) conductance or an increased Na/K-ATPase activity or both. Low K(+) or high insulin concentrations both reduced the activity of the circular muscle of the abomasal corpus (i.e., of the part that is responsible for the propulsion of abomasal chymus) and might play an important role in the pathogenesis of abomasal displacement.

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Section: Introductionmentioning

confidence: 99%

Potassium and insulin affect the contractility of abomasal smooth muscle

Türck

Leonhard-Marek

2010

Journal of Dairy Science

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“…This indicates that the tissues are insensitive to insulin with regard to uptake of glucose, which points to insulin resistance. It has been postulated that high insulin levels could play a role in the pathogenesis of abomasal displacement (23).…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the degree of energy deficiency and especially on the preparturient fat status of the animal, the amount of fat droplets in the hepatocytes can be so high that it interferes with normal liver cell function (13). Abomasal displacement, besides other complications as chronic ketosis, parturient paresis, retained placenta and endometritis, has often been associated with a fatty liver (3,5,20,23).…”

Section: Introductionmentioning

confidence: 99%

Biochemical Profiles in Cows with Abomasal Displacement Estimated by Blood and Liver Parameters*

Muylle

Hende

Sustronck

et al. 1990

Journal of Veterinary Medicine Series A

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The metabolic status of normal lactating cows and of cows suffering from abomasal dilatation was evaluated by examination of blood parameters and by determination of the fat and glycogen content in liver biopsies. The method for examination of the liver biopsies is described.In clinically normal lactating cows the liver contains less than 20 mg triglycerides (TG) and more than 20 mg glycogen per gram of wet tissue. Cows suffering from abomasal displacement all showed hyperglycemia and in most of them a fatty to very fatty liver was found.The degree of hyperglycemia depends on the amount of liver glycogen and is independent of the liver TG content. The degree of ketonemia also depends on the liver glycogen content.

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“…1 Medical treatment of cattle suspected to have abomasal hypomotility is widely practiced, but few data are available on treatment efficacy. 2 Because abomasal hypomotility has been associated with hypocalcaemia, 3,4 endotoxemia, 5 alkalemia, 6 hyperinsulinemia, 7 and hyperglycemia, 8,9 the current focus of treatment of adult cattle and calves suspected to have abomasal hypomotility is correction of acidbase, electrolyte, and metabolic abnormalities; amelioration of the effects of endotoxemia; and elimination of gram-negative bacterial infections. Some clinicians also administer neostigmine, metoclopramide, or erythromycin to ruminants suspected to have abomasal hypomotility, on the basis of evidence to suggest that these medications have a prokinetic effect in neonatal 10 and adult humans 11 and domestic monogastric animals.…”

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confidence: 99%