The influence of lack of oxygen on tissue respiration

Verzár, Fritz

doi:10.1113/jphysiol.1912.sp001533

Cited by 38 publications

(9 citation statements)

References 4 publications

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“…This conclusion is borne out also for the salivary glands by the ingenious experiments of Ve r zar (9), but in the case of muscles V er z ar found that their oxygen tension must be comparatively low and perhaps 0, since a diminution of the arterial supply (and pressure) of oxygen caused a distinct decrease in the oxygen absorption of the muscular tissue.…”

Section: A Kroghmentioning

confidence: 87%

The supply of oxygen to the tissues and the regulation of the capillary circulation

Krogh¹

1919

The Journal of Physiology

476

257

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Section: A Kroghmentioning

confidence: 87%

The supply of oxygen to the tissues and the regulation of the capillary circulation

Krogh¹

1919

The Journal of Physiology

476

257

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“…Since the last century (Verzár 1912), the increase in muscle blood flow elicited by muscle contractions has been postulated to be a response evoked by the muscle itself in order to fulfill its O 2 requirements. Although muscle blood flow is the major determinant of convective O 2 delivery, it interacts with other factors such as O 2 unloading from haemoglobin (Hb) and O 2 diffusion from the erythrocytes to the mitochondria.…”

mentioning

confidence: 99%

Oxygen tension and content in the regulation of limb blood flow

Calbet

2000

Acta Physiologica Scandinavica

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During submaximal exercise, muscle blood flow increases when arterial oxygen content (CaO2) is reduced. The increase in blood flow is brought about by elevating cardiac output (CO) and enhancing leg vascular conductance. Conversely, increased CaO2 elicits lower limb blood flow (LBF) and CO. During maximal exercise, the influence of CaO2 on muscle blood flow is modulated depending on the amount of muscle mass recruited. When a small muscle mass is activated and the pumping capacity of the heart is not limited, changes in CaO2 barely influence the level of blood flow attained at peak exercise. However, when a large muscle mass is engaged in the exercise, as occurs for example during cycling and running, muscle blood flow is decreased if maximal CO is reduced, as happens during exercise in severe hypoxia. In contrast, maximal muscle blood flow and CO are maintained at peak exercise when CaO2 is increased. As such, exercise intensity, muscle mass and CaO2 appear to be the critical factors determining muscle blood flow during exercise.

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“…Previous attempts to measure gas tensions of tissues have involved the analyses of the gaseous composition of body fluids (1)(2)(3), the sampling of gas from artificial pockets created within tissues (4)(5)(6)(7)(8), and the direct implantation of polarographic electrodes (9)(10)(11). Unfortunately, results obtained by such methods are apt to be unreliable because of artefacts incident to the introduction of electrodes into tissues, the lack of dependable instruments for the precise measurement of the small quantities of oxygen in biological fluids, and the inability to calibrate electrodes implanted in tissues.…”

mentioning

confidence: 99%