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The catabolism takes place according to the equation ioo gr. fat + (76-5?! + 12 V-11-5) gr. O 2 = 76-5$$ gr. CO 2 + 12 V gr. water, or ioo gr. fat + 288-5 gr. O 2 = 280-5 gr. CO 2 + 108 gr. water. The 280-5 g r-CO 2 contain 28o'5ff = 204 gr. O 2 and the respiratory quotient is therefore f-f^= 0707. Similar computations can be made for proteins, but as the percentage composition of different proteins is not the same, and as the catabolism is incomplete and to a certain extent variable, the results may vary from about 078 to 0-82. The average respiratory quotient of protein is generally taken as 0*80. The respiratory quotient of alcohol is 0-667. The respiratory quotients met with in animals usually lie between 0*97 and 0-72. When nothing further has been determined a low respiratory quotient will indicate qualitatively that the material catabolized is chiefly fat and protein, and a high that it is chiefly carbohydrate and protein ; but quantitative results cannot be obtained. When the amount of protein catabolized is known, generally in the form of the quantity of nitrogen in the corresponding urine, the corresponding quantities of O 2 and CO 2 , which have been given by Zuntzas 8-471 gr. = 5-923 litre O 2 and 9-347 gr. = 4754 litre CO 2 per gr. N