The Influence of Long-Term Peroral Administration of Gold Nanoparticles with Various Sizes on the Liver, Spleen, and Lymph Nodes of Laboratory Rats and Their Progeny

Pakhomy, Svetlana S.; Bucharskaya, Alla B.; Maslyakova, Gаlina N.; Злобина, О. В.; Bugaeva, I. O.; Navolokin, Nikita; Mudrak, D. A.; Khlebtsov, Boris N.; Богатырев, В. А.; Khlebtsov, N. G.

doi:10.1134/s0030400x19060195

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…LNs 3D analysis showed that the accumulation of GC-AuNPs in LNs increased with time. However, some studies have shown morphological changes in the liver, spleen, and LNs of adult rats during the long-term administration of GNPs [ 174 ]. And the accumulated gold nanoparticles induce oxidative stress through ROS production, so their safety remains the biggest obstacle for clinical application.…”

Section: Application Of Nano-delivery Systems In Lnsmentioning

confidence: 99%

Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy

Xia

et al. 2023

Nano-Micro Lett.

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Immunotherapy has become a promising research “hotspot” in cancer treatment. “Soldier” immune cells are not uniform throughout the body; they accumulate mostly in the immune organs such as the spleen and lymph nodes (LNs), etc. The unique structure of LNs provides the microenvironment suitable for the survival, activation, and proliferation of multiple types of immune cells. LNs play an important role in both the initiation of adaptive immunity and the generation of durable anti-tumor responses. Antigens taken up by antigen-presenting cells in peripheral tissues need to migrate with lymphatic fluid to LNs to activate the lymphocytes therein. Meanwhile, the accumulation and retaining of many immune functional compounds in LNs enhance their efficacy significantly. Therefore, LNs have become a key target for tumor immunotherapy. Unfortunately, the nonspecific distribution of the immune drugs in vivo greatly limits the activation and proliferation of immune cells, which leads to unsatisfactory anti-tumor effects. The efficient nano-delivery system to LNs is an effective strategy to maximize the efficacy of immune drugs. Nano-delivery systems have shown beneficial in improving biodistribution and enhancing accumulation in lymphoid tissues, exhibiting powerful and promising prospects for achieving effective delivery to LNs. Herein, the physiological structure and the delivery barriers of LNs were summarized and the factors affecting LNs accumulation were discussed thoroughly. Moreover, developments in nano-delivery systems were reviewed and the transformation prospects of LNs targeting nanocarriers were summarized and discussed.

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Section: Application Of Nano-delivery Systems In Lnsmentioning

confidence: 99%

Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy

Xia

et al. 2023

Nano-Micro Lett.

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“…For any widely used material, safety is always a focus and potential toxicity toward living cells is one of the key factors for that. The cytotoxicity of nanomaterials is a current topic for many researchers, especially those dealing with materials for medical purposes [1][2][3]. Among the metals used by the industry in nanomaterials, silver is known to have a high toxicity toward many microorganisms [4,5] and viruses [2,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In general, the toxicity depends on the metal's form, oxidation state, solubility, and concentration [2,4]. For silver nanoparticles, it has been shown that their toxicity is hardly affected by their shape, size, and crystal structure [3,4]. In some cases, cytotoxicity has been studied as a function of nanoparticles' concentration and exposure time.…”

Section: Introductionmentioning

confidence: 99%

The Synthesis and Analysis of the Cytotoxicity of Al2O3-Supported Silver Nanoparticles Prepared by the Plasma Chemical Process Initiated by Pulsed MW Radiation in the Al2O3–Ag Powder Mixtures

Skvortsova,

Akhmadullina,

Vafin

et al. 2024

IJMS

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An original plasma chemical process initiated by microwave discharge in a mixture of metal and dielectric powders was applied to prepare specific materials, which consisted of microsized spherical particles of aluminum oxide covered with silver nanoparticles. The prepared materials are highly uniform in shape, size distribution, and composition. Their cytotoxicity was investigated using the human cell lines MCF7, HEK293T, A549, and VA-13 and the bacterial strains E. coli JW5503 (ΔtolC) and E. coli K12. Their cytotoxicity was found not to exceed the cytotoxicity of the starting materials. Thus, the prepared materials can be considered highly promising for catalysis and biotechnology applications.

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