The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice

Couteur, David G. Le; Tay, Szun S.; Solon-Biet, Samantha M.; Bertolino, Patrick; McMahon, Aisling C.; Cogger, Victoria C.; Colakoglu, Feyza; Warren, Alessandra; Holmes, Andrew; Pichaud, Nicolas; Horan, Martin; Correa, Carolina; Melvin, Richard G; Turner, Nigel; Ballard, J. William O.; Ruohonen, Kari; Raubenheimer, David; Simpson, Stephen J.

doi:10.1093/gerona/glu196

Cited by 34 publications

(31 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-term investigations in ad libitum-fed mice across 25 different diets varying in macronutrient composition support these findings, showing that latelife health and longevity were optimized not by reducing energy intake, but by low P:C diets (Solon-Biet et al 2014). In an attempt to stabilize protein intake, mice displayed a compensatory increase in food intake on low protein diets, resulting in increased energy intake and greater adiposity, but experienced a significant increase in lifespan, improved blood pressure, lipid profiles, mitochondrial function, insulin sensitivity (Solon-Biet et al 2014) and immune function (T and B cell populations) measured at 15 months (Le Couteur, et al 2014). These health and longevity consequences were shown to be related to circulating branched chain amino acid (BCAA) levels, which, interestingly, were the only amino acids to be positively correlated to protein intake under chronic feeding conditions.…”

Section: Macronutrient Balancementioning

confidence: 99%

Macronutrients and caloric intake in health and longevity

Solon-Biet¹,

Mitchell²,

Cabo³

et al. 2015

Journal of Endocrinology

Self Cite

123

View full text Add to dashboard Cite

Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.

show abstract

Section: Macronutrient Balancementioning

confidence: 99%

Macronutrients and caloric intake in health and longevity

Solon-Biet¹,

Mitchell²,

Cabo³

et al. 2015

Journal of Endocrinology

Self Cite

123

View full text Add to dashboard Cite

show abstract

“…In AL-fed mice and Drosophila melanogaster , diets low in protein and high in carbohydrates (LPHC) maximized lifespan, while reduction of total energy intake had no positive impact on longevity (Lee et al, 2008; Solon-Biet et al, 2014). Moreover in mice, LPHC diets were associated with improved latelife cardiometabolic health (Solon-Biet et al, 2014) and a younger immune profile (Le Couteur et al, 2014). Low protein intake has also been associated with better health and reduced mortality in observational studies of humans (Levine et al, 2014), while high protein, low carbohydrate diets (HPLC) are associated with higher mortality, cardiovascular disease, and diabetes mellitus (Fontana and Partridge, 2015; Fung et al, 2010; Lagiou et al, 2012; Simpson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

et al. 2015

Self Cite

View full text Add to dashboard Cite

Summary Both caloric restriction (CR) and low protein, high carbohydrate (LPHC) ad libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose and blood lipids. Severe CR, however, is unsustainable for most people; therefore, it is important to determine whether manipulating macronutrient ratios in ad libitum-fed conditions can generate similar health outcomes. We present the results of a short-term (8 week) dietary manipulation on metabolic outcomes in mice. We compared three diets varying in protein to carbohydrate ratio under both CR and ad libitum conditions. Ad libitum LPHC diets delivered similar benefits to CR in terms of levels of insulin, glucose, lipids and HOMA, despite increased energy intake. CR on LPHC diets did not provide additional benefits relative to ad libitum LPHC. We show that LPHC diets under ad libitum-fed conditions generate the metabolic benefits of CR without a 40% reduction in total caloric intake.

show abstract

“…SIRT1 also plays a key role in the reduction of brain inflammation. Activation of SIRT1 via resveratrol administration attenuated microglial inflammation in a mouse cell line, possibly through the modulation of several transcription factors including the pro-inflammatory cytokine NF-κB (Li et al, 2015). …”

Section: Unraveling the Relationships Among Calorie Restriction Lmentioning

confidence: 99%

“…LPHC diets were found to inhibit hepatic mTOR, providing a mechanism linking this type of ad libitum diet to delayed aging. GF was utilized to unravel the complex effects of macronutrients on metabolic health, lifespan (Solon-Biet et al, 2014), immunity (Le Couteur et al, 2015), reproduction (Solon-Biet et al, 2015b) and microcirculation (Cogger et al, 2016). GF methodology is therefore likely to provide insight into how dietary energy and macronutrients influence brain aging and dementia.…”

Section: The Geometric Framework Diet and Cognitionmentioning

confidence: 99%

Nutritional strategies to optimise cognitive function in the aging brain

Wahl

Cogger

Solon-Biet

et al. 2016

Ageing Research Reviews

Self Cite

View full text Add to dashboard Cite

Old age is the greatest risk factor for most neurodegenerative diseases. During recent decades there have been major advances in understanding the biology of aging, and the development of nutritional interventions that delay aging including calorie restriction (CR) and intermittent fasting (IF), and chemicals that influence pathways linking nutrition and aging processes. CR influences brain aging in many animal models and recent findings suggest that dietary interventions can influence brain health and dementia in older humans. The role of individual macronutrients in brain aging also has been studied, with conflicting results about the effects of dietary protein and carbohydrates. A new approach known as the Geometric Framework (GF) has been used to unravel the complex interactions between macronutrients (protein, fat, and carbohydrate) and total energy on outcomes such as aging. These studies have shown that low-protein, high-carbohydrate (LPHC) diets are optimal for lifespan in ad libitum fed animals, while total calories have minimal effect once macronutrients are taken into account. One of the primary purposes of this review is to explore the notion that macronutrients may have a more translational potential than CR and IF in humans, and therefore there is a pressing need to use GF to study the impact of diet on brain aging. Furthermore, given the growing recognition of the role of aging biology in dementia, such studies might provide a new approach for dietary interventions for optimizing brain health and preventing dementia in older people.

show abstract

The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice

Cited by 34 publications

References 40 publications

Macronutrients and caloric intake in health and longevity

Macronutrients and caloric intake in health and longevity

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

Nutritional strategies to optimise cognitive function in the aging brain

Contact Info

Product

Resources

About