The influence of mannitol on morphology and disintegration of spray-dried nano-embedded microparticles

Torge, Afra; Grützmacher, Philipp G.; Mücklich, Frank; Schneider, Marc

doi:10.1016/j.ejps.2017.04.003

Cited by 60 publications

(37 citation statements)

References 36 publications

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“…To prevent recrystallization of amorphous drugs, the powders are stored under dry conditions. An option to minimize the potential of activity loss during the nano spray drying process is to cool the feed vessel in ice bath (≥ 4 °C) (Amsalem et al 2017;Schoubben et al 2013;Torge et al 2017) or to use a larger spray mesh (e.g. 7.0 μm) to reduce the mechanical shear of atomization (Abdel-Mageed et al 2019;Bürki et al 2011).…”

Section: Particle Morphologymentioning

confidence: 99%

PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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Background Spray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The Nano Spray Dryer B-90 of the Swiss company Büchi Labortechnik AG extends the size of the powder particles produced into the nanometer scale with narrow size distributions and high encapsulation efficiency. Area covered This study explains the special nano spray drying technology and discusses the influence of the respective process parameters on the powder properties. Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. Optimized process parameters for the application of nano spray drying of similar substances are presented. Expert opinion The analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.

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Section: Particle Morphologymentioning

confidence: 99%

PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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“…• The hygroscopic excipient mannitol is especially advantageous for the treatment of bacterial infections in cystic fibrosis [70,71]. albumin particles were approximately 0.7, 1.7, and 2.6 μm in size respectively at 1% (w/v) solid concentration.…”

Section: Figurementioning

confidence: 99%

“…• cystic fibrosis (e.g. antibacterial dexketoprofen in Kollidon and Eudragit nanoparticles, or azithromycin in leucine) [64,70,71],…”

Section: Applications Of Nano Spray Dried Pharmaceuticals On the Labomentioning

confidence: 99%

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus¹

2018

Int J Med Nano Res

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Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder particles to the submicron-and nanoscale with very narrow size distributions and sample quantities in the milligram scale at high product yields. This enables the economical use of expensive active pharmaceutical ingredients and pure drugs. The present paper explains the concept of nano spray drying in the laboratory-scale and discusses the influence of the main process parameters on the final powder properties like particle size, morphology, encapsulation efficiency, and drug loading. Application results of nano spray drying for the formulation and encapsulation of different drugs are reviewed.

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“…After deposition, nanoparticles can be released to show their therapeutic advantages such as a controlled drug release and delivery of the drug across the mucus barrier. The selection of an apt excipient to embed the nanoparticles is essential for the satisfactory deposition and sustained release of nanoparticles [28,46]. By knowing this context researchers investigated various NEMs based DPIs for effective delivery of anti-TB drugs (Table 3).…”

Section: Nanoparticles Embedded Microparticlesmentioning

confidence: 99%

Potential of dry powder inhalers for tuberculosis therapy: facts, fidelity and future

Mehta

Bothiraja

Kadam

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Tuberculosis (TB) is a contagious and airborne infectious disease caused by the pathogen Mycobacterium tuberculosis (Mtb). In spite of substantial research efforts, continuous multiple high-dose drug therapy regularly for 4-7 months can impede patient quality of life. The pathology of TB and biology of pulmonary airways permits for a variety of drug delivery strategies and natural route of infection denotes a more logical remedial approach for treatment of TB. Pulmonary delivery is non-invasive, allow easy transcytosis in alveolar region, avoids first-pass metabolism and extensive vascularization facilitates delivery of therapeutic agents to infection site. It also potentially reduces the frequency with dose requirement and linked side effects. Dry powder is a most preferred inhalation option due to their greater physiochemical stability over liquid or suspension based formulations. Dry powder inhalers (DPIs) are easy to handle and appropriate for high-dose formulations. Moreover, the progress of disciplines such as nanotechnology, particle engineering, material science and molecular biology permits further expansion of treatment capability and efficiency. Thus, this article will focus on the role of novel DPIs systems for treatment of TB. This article also contains a dedicated section discussing about technical limitations and clinical challenges with help of strengths, weaknesses, opportunities and threats (SWOT) analysis. Additionally, it will also offer some basic background information for drug repurposing, formulation development and drug delivery systems.

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The influence of mannitol on morphology and disintegration of spray-dried nano-embedded microparticles

Cited by 60 publications

References 36 publications

PLA/PLGA nanoparticles prepared by nano spray drying

PLA/PLGA nanoparticles prepared by nano spray drying

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Potential of dry powder inhalers for tuberculosis therapy: facts, fidelity and future

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