The influence of marital status on survival in patients with nasopharyngeal carcinoma: A surveillance, epidemiology, and end results database analysis

Yu, Bin; Lin, Fei; Duan, Jie; Hong, Nian

doi:10.1097/md.0000000000030516

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Furthermore, marital status has been associated with disparities in early cancer diagnoses ( 33 ). Previous results suggested that married patients are more likely to receive earlier clinical diagnoses, which generally correspond to better prognoses ( 34 , 35 ), whereas unmarried patients often face delays in diagnosis and may not receive adequate treatment ( 36 ). These factors highlight the potential role of maintaining a good marital relationship can therefore improve the prognosis of patients with NECB.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and survival outcomes of neuroendocrine carcinoma of the breast: a SEER data analysis

Xia,

Lai,

Liu

et al. 2023

Transl Cancer Res

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Background Neuroendocrine carcinoma of the breast (NECB) is a rare subtype of breast cancer, comprising only 0.1% to 5% of all breast cancer cases. Despite its rarity, it is important to gain a better understanding of the epidemiological, clinical, and prognostic features of NECB. The purpose of the study was to obtain population-based evaluations of the epidemiological and survival outcomes of NECB. Methods The data of patients with neuroendocrine carcinoma diagnosed and enrolled between 2000 and 2017 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Descriptive statistical analyses were used to assess the distribution and tumor-related characteristics of these patients. Kaplan-Meier curves and univariate and multivariate Cox proportional risk models were used to analyze variables that might be associated with prognosis. Results This study included 7,856 patients with neuroendocrine carcinoma. The median age of the patients was 64 years, and most of them were female, White, and diagnosed at ≥60 years old. The most common pathological type was neoplasm. Survival analysis indicated that there were significant differences in age, marital status, registration location, American Joint Committee on Cancer (AJCC) stage, breast subtype, surgery of primary tumor, and no cancer cause surgery patients with NECB. The results also indicated that treatment with surgery, including surgery of primary tumor, surgery combined with radiation, and no cancer cause surgery, were all effective in improving the prognosis compared with not providing surgical treatment. Conclusions In conclusion, NECB is a very rare lesion for which age, marital status, registration location, and surgery, AJCC stage, breast subtype were found to be independent prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Epidemiological and survival outcomes of neuroendocrine carcinoma of the breast: a SEER data analysis

Xia,

Lai,

Liu

et al. 2023

Transl Cancer Res

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“…The time of index date was the date one year after the NPC diagnosis. To make the general condition of our study population more homogenous, the following exclusion criteria were obeyed to discard patients with extreme morbidity: (1) age younger than 20 years old, (2) blindness before the index date, (3) the diagnosis of ocular tumor before index date, (4) the receipt of eyeball removal before the index date, (5) the receipt of corneal transplantation before the index date, (6) achievement of outcome before index date, (7) died before index date. After the exclusion process, we performed two matching processes for the constitution of NPC and non-NPC groups.…”

Section: Patient Selectionmentioning

confidence: 99%

“…The Epstein-Barr virus, human papillomavirus, and tobacco smoking were shown to be causally linked to the development of NPC [1,3,4]. Currently, the main treatments for NPC are radiotherapy and chemotherapy, with a recurrence rate of approximately 10-20 percent [5,6], and the median of survival period is 3 years in the advanced stage, which could be influenced by marital status [7,8].…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal Carcinoma and Its Effect on Dry Eye Disease: A Nationwide Cohort Study

Chen

Yang

Chao

et al. 2022

IJERPH

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The aim of the current study was to investigate the relationship between nasopharyngeal carcinoma (NPC) and dry eye disease (DED) using the National Health Insurance Research Database (NHIRD) of Taiwan. A retrospective cohort study was conducted, and patients with an NPC diagnosis were included. Next, one NPC patient was matched to four non-NPC participants via demographic data and systemic comorbidities. In total, 4184 and 16,736 participants were enrolled in the NPC and non-NPC groups, respectively. The primary outcome was the development of DED one year after the diagnosis of NPC. Cox proportional hazard regression was applied to estimate the adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of DED. In this study, 717 and 2225 DED cases were found in the NPC and non-NPC groups, respectively, and the NPC group showed a significantly higher incidence of DED development compared to the non-NPC group (aHR: 1.45, 95% CI: 1.33–1.58, p < 0.0001) in the multivariable analysis. The other covariates that were positively correlated with DED development included age over 40 years, an education level higher than senior high school, hypertension, DM, allergic pulmonary diseases, allergic otolaryngologic diseases, and allergic dermatological diseases (all p < 0.05). In conclusion, the presence of NPC is an independent risk factor for subsequent DED.

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“…The choices of treatments for the NPC involve chemotherapy and radiotherapy and the recurrence of NPC is not uncommon [5,6]. The mean survival interval of late-stage NPC patients were near 3 years which could be further shortened if the patient was under the divorce status [7,8].…”

Section: Introductionmentioning

confidence: 99%

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

Lu¹,

Lin²,

Hsin³

et al. 2023

Int. J. Med. Sci.

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This study aimed to investigate the possible association between nasopharyngeal carcinoma (NPC) and following open angle glaucoma (OAG). A retrospective research applying the National Health Insurance Research Database (NHIRD) of Taiwan was conducted with a follow up period from January 1, 2000 to December 31, 2016. There were 4184 and 16736 participants that selected and categorized into the NPC and non-NPC groups after exclusion. The major outcome of our study was the development of OAG according to diagnostic codes, exam and managements. The Cox proportional hazard regression was employed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of OAG between the two groups. In this study, a numbers of 151 and 513 OAG episodes occurred in the NPC and non-NPC groups and the NPC population showed a significantly higher incidence of OAG compared to the non-NPC population in multivariable analysis (aHR: 1.293, 95% CI: 1.077-1.551, p = 0.0057). Besides, the cumulative probability of OAG was significantly higher in the NPC group than that in the non-NPC population (p = 0.0041). About other risk factor for OAG, age older than 40 years old, diabetes mellitus and persistent steroid usage were related to OAG occurrence (all p < 0.05). In conclusion, the NPC may be an independent risk factor of following OAG development.

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The influence of marital status on survival in patients with nasopharyngeal carcinoma: A surveillance, epidemiology, and end results database analysis

Cited by 4 publications

References 26 publications

Epidemiological and survival outcomes of neuroendocrine carcinoma of the breast: a SEER data analysis

Epidemiological and survival outcomes of neuroendocrine carcinoma of the breast: a SEER data analysis

Nasopharyngeal Carcinoma and Its Effect on Dry Eye Disease: A Nationwide Cohort Study

Association of the nasopharyngeal carcinoma and the subsequent open glaucoma development: a nationwide cohort study

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