The influence of matrix and laser energy on the molecular mass distribution of synthetic polymers obtained by MALDI-TOF-MS

Wetzel, S; Guttman, Charles M.; Girard, James E.

doi:10.1016/j.ijms.2004.04.019

Cited by 70 publications

(44 citation statements)

References 27 publications

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“…These results verify previous observations that average molecular mass plays a significant role in the ability to accurately quantify polymer blends [29][30][31]. Our interpretation of these results is that the most accurate wt% PEG quantitation will be obtained when the added PEG is closest in average molar mass to the observed residual PEG in the ethoxylated surfactant.…”

Section: Effect Of Molar Mass Of the Selected Peg Standardsupporting

confidence: 89%

Development of a Combined Standard Additions/Internal Standards Method to Quantify Residual PEG in Ethoxylated Surfactants by MALDI TOFMS

Szyszka

Hanton

Henning

et al. 2011

J. Am. Soc. Mass Spectrom.

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Measuring the residual polyethylene glycol (PEG) in polyethylene oxide (PEO)-based surfactants is important to fully understanding the performance of these materials. Traditional methods of quantitating PEG in PEO-based surfactants can be time-consuming and struggle with low amounts or overlapping molecular mass distributions. This paper describes a matrixassisted laser desorption/ionization (MALDI) mass spectrometry method developed to quantitate residual PEG in a series of ethoxylated surfactants. The technique addresses the difficulties faced in doing quantitative MALDI experiments by utilizing both internal standard and standard additions protocols. The method produces excellent straight line standard addition plots, and the quantitative results are verified using both a constructed standard and an independent traditional chromatographic separation.

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Section: Effect Of Molar Mass Of the Selected Peg Standardsupporting

confidence: 89%

Development of a Combined Standard Additions/Internal Standards Method to Quantify Residual PEG in Ethoxylated Surfactants by MALDI TOFMS

Szyszka

Hanton

Henning

et al. 2011

J. Am. Soc. Mass Spectrom.

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“…the distribution of the molecular weight for each polymeric fraction (Table 1). According to the molecular mass distribution obtained from SEC chromatograms, PCE1 showed an almost unimodal distribution around 5000 g mol Finally, the use of MALDI-TOF mass spectrometry gave important parameters regarding the architecture of the molecular structure of the two superplasticizers, as it is an analytical technique with capability to provide information about molecular mass, end group and branching of the polymers [32]. MALDI-TOF is able to provide a mass spectrum reflecting the oligomers distribution and their relative amounts.…”

Section: Characterization Of the Polycarboxylate Ester Copolymersmentioning

confidence: 99%

Assessment of the interaction of polycarboxylate superplasticizers in hydrated lime pastes modified with nanosilica or metakaolin as pozzolanic reactives

Navarro-Blasco

Perez-Nicolas

Fernández

et al. 2014

Construction and Building Materials

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Two polycarboxylate ether copolymers were assessed as superplasticizers (SPs) for hydrated lime pastes modified with two reactive compounds, nanosilica (NS) and ceramic metakaolin (MK). Characterization of the molecular structure of the SPs by Size Exclusion Chromatography, XRD, FTIR and MALDI-TOF (Matrix Assisted LaserDesorption Ionization Time-of-Flight) mass spectrometry was performed. The structures of the polymers were seen to be star-and worm-like shapes. A close relationship was found between the molecular architecture and the flowability of the pastes, being the star-shaped plasticizer the most efficient. Zeta potential assessment allowed us to elucidate a steric hindrance as the main action mechanism for these polymers. The large specific surface area of nanosilica led to a large SPs consumption as compared with metakaolin with lower surface area. However, SPs in MK-lime samples were attached favourably on the C-S-H and aluminate hydrates, so that the dispersing action was greater with respect to NS-lime suspensions.2

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“…This difference in the effect of laser energy on the S/N is attributable to the difference in the matrix properties. Dithranol requires more laser energy than RA to ablate polystyrene into the gas phase [9]. In summary, the best settings for polystyrene in dithranol are (detector voltage ϭ ϩ, laser energy ϭ ϩ, parameter effects are seen for delay time, the interaction between delay time and laser energy, and the interaction between delay time and detector voltage.…”

Section: Resultsmentioning

confidence: 99%

“…These parameters, as well as laser energy, were most influential for the polystyrene with dithranol as the matrix. any factors influence the quality of matrixassisted laser desorption/ionization (MALDI) time-of flight (TOF) mass spectra of synthetic polymers [1][2][3][4][5][6][7][8][9][10][11]. Foremost is the nature of the sample itself.…”

mentioning

confidence: 99%

“…The matrix type and concentrations of the polymer analyte and matrix salt used to prepare the sample have also been shown to influence the polymer distribution obtained by MALDI-TOF-MS [16 -18]. Laser energy has been shown to cause fragmentation in some polymers while often higher mass oligomers require higher laser energies for desorption [9]. Even with a given sample preparation, instrument-toinstrument variation may be significant [19].…”

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confidence: 99%

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Significant parameters in the optimization of MALDI-TOF-MS for synthetic polymers

Wetzel

Guttman

Flynn

et al. 2006

J. Am. Soc. Mass Spectrom.

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One of the most significant issues in any analytical practice is optimization. Optimization and calibration are key factors in quantitation. In matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), instrument optimization is a limitation restricting quantitation. An understanding of the parameters that are most influential and the effects of these parameters on the mass spectrum is required for optimization. This understanding is especially important when characterizing synthetic polymers by MALDI-TOF-MS, due to the breadth of the polymer molecular mass distribution (MMD). Two considerations are important in quantitation, additivity of signal and signal-to-noise (S/N). In this study, the effects of several instrument parameters were studied using an orthogonal experimental design to understand effects on the signal-to-noise (S/N) of a polystyrene distribution. The instrument parameters examined included detector voltage, laser energy, delay time, extraction voltage, and lens voltage. Other parameters considered were polymer concentration and matrix. The results showed detector voltage and delay time were the most influential of the instrument parameters for polystyrene using all trans-retinoic acid (RA) as the matrix. These parameters, as well as laser energy, were most influential for the polystyrene with dithranol as the matrix. (J Am Soc Mass Spectrom 2006, 17, 246 -252)

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The influence of matrix and laser energy on the molecular mass distribution of synthetic polymers obtained by MALDI-TOF-MS

Cited by 70 publications

References 27 publications

Development of a Combined Standard Additions/Internal Standards Method to Quantify Residual PEG in Ethoxylated Surfactants by MALDI TOFMS

Development of a Combined Standard Additions/Internal Standards Method to Quantify Residual PEG in Ethoxylated Surfactants by MALDI TOFMS

Assessment of the interaction of polycarboxylate superplasticizers in hydrated lime pastes modified with nanosilica or metakaolin as pozzolanic reactives

Significant parameters in the optimization of MALDI-TOF-MS for synthetic polymers

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