The influence of measles vaccination on the incidence of otosclerosis in Germany

Arnold, W.; Busch, Raymonde; Arnold, A.; Ritscher, Björn; Neiss, A; Niedermeyer, Hans P.

doi:10.1007/s00405-007-0253-9

Cited by 41 publications

(24 citation statements)

References 32 publications

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“…However, there have been conflicting results as in the study by Grayeli et al [49], which could not detect measles virus RNA in the otosclerotic bone. According to the study of Arnold et al [50] and Niedermeyer et al [51,52], anti-measles vaccination seems to be correlated with decreasing numbers of stapes surgery as well as increasing age of patients at the time of surgery. In conclusion, a great body of evidence suggests that otosclerosis is an inflammatory disease associated with persistent measles virus infection.…”

Section: Persistent Measles Virus Infection In Otosclerosismentioning

confidence: 95%

Etiopathogenesis of otosclerosis

Karosi

Sziklai

2010

Eur Arch Otorhinolaryngol

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The objectives of our study was to review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance to pharmacotherapy. Relevant publications on the etiopathogenesis, molecular biology, genetics and histopathology of otosclerosis from 1984 to 2009 were analyzed. Otosclerosis is a bone remodeling disorder of the human otic capsule; however, the etiopathogenesis remains unclear. Genetic predisposition, disturbed bone metabolism, persistent measles virus infection, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. Since diagnosis of otosclerosis is still based on histopathological examination of the removed stapes footplate, systemic prospective studies based on comprehensive histopathological and molecular biological analysis are necessary to obtain further information on the background of the disease.

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Section: Persistent Measles Virus Infection In Otosclerosismentioning

confidence: 95%

Etiopathogenesis of otosclerosis

Karosi

Sziklai

2010

Eur Arch Otorhinolaryngol

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“…It is well known that vaccination against measles provides a milder seropositivity (serum anti-measles IgG level) than natural infection [ 82 , 86 , 87 ]. In populations of different countries, as high as >20 % of the vaccinated population exhibited negligible anti-measles IgG serum levels, which may indicate the necessity of a revaccination [ 82 ]. The low response rate to vaccination makes possible subclinical measles infection that can be the cause of a persistent measles virus presence in the affected individuals.…”

Section: Etiopathogenetic Models For Otosclerosismentioning

confidence: 95%

The Putative Role of Measles Virus in the Pathogenesis of Otosclerosis

Karosi

Sziklai

2016

Surgery of Stapes Fixations

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“…Recently, we published our results of all patients that were hospitalized in Germany for otosclerosis from 1993 to 2004 [47] . Summarizing, we analyzed data obtained from the Federal Office of Statistics (Wiesbaden, Germany) based on the International Classification of Diseases (ICD) code (ICD-9: 387; ICD-10: H80) which defines otosclerosis unequivocally.…”

Section: And Otosclerosis: Consistency Of Associationmentioning

confidence: 99%

Otosclerosis and Measles Virus – Association or Causation?

Niedermeyer

Arnold²

2008

ORL

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Otosclerosis is a frequent condition which occurs exclusively in the human temporal bone. This peculiar disease affects mainly Caucasians and Indians and may cause conductive, mixed conductive-sensorineural or occasionally merely sensorineural hearing loss. Morphological investigations of the otosclerotic focus show all three phases of a chronic inflammation with bone resorption, formation of new bone and finally eburnation. Various hypotheses about the cause of inflammation were proposed in the past. Immunological reactivity to collagen, the existence of otosclerosis genes (OTSC 1–5) including mutations of the collagen gene 1A1 and 1A2 or a measles virus (MV) infection were suggested. The existence of the MV proteins and RNA within the otosclerotic tissue has been shown by several authors. However, due to mainly technical problems, no further progress to elucidate the role of the virus could be made. Epidemiological studies revealed a dramatic decrease of measles and related diseases such as the subacute sclerosing panencephalitis since the introduction of MV vaccination programs in USA and Europe. Indeed, some surgeons reported decreasing numbers of stapes surgery and a shift towards elder patients. Our epidemiological survey of all patients hospitalized with otosclerosis in Germany between 1993 and 2004 demonstrates a highly significant decrease in otosclerosis among the population vaccinated against the MV. The strong correlation makes it most plausible that the MV is at least one triggering factor for the development of otosclerosis.

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The influence of measles vaccination on the incidence of otosclerosis in Germany

Abstract: The pathologic process of otosclerosis is characterized by an inXammatory lytic phase followed by an abnormal bone remodeling at very speciWc sites of predilection. There is a clear genetic predisposition with about half of all cases occurring in families with more than one aVected member.

Cited by 41 publications

References 32 publications

Etiopathogenesis of otosclerosis

Etiopathogenesis of otosclerosis

The Putative Role of Measles Virus in the Pathogenesis of Otosclerosis

Otosclerosis and Measles Virus – Association or Causation?

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