The Influence of Melanin on the Gastric Mucosa and Hypothalamicpituitary-Adrenocortical Axis Under Acute Stress Conditions

D.V., Golyshkin D.V. Golyshkin; T.M., Falalyeyeva T.M. Falalyeyeva; K.S., Neporada K.S. Neporada; Beregova, Beregova T.V.

doi:10.15407/fz61.02.065

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…This is consistent with previous studies, where melanin was shown to reduce the level of pro-inflammatory cytokine IL-1β and restore the level of antiinflammatory cytokines (IL-10, TGF-b) in the serum of rats with non-alcoholic liver disease induced by monosodium glutamate (Belemets, 2017). As noted previously, the antioxidant properties of melanin are linked to its anti-inflammatory, antitumour and gastroprotective effects, as demonstrated in several articles (Falalyeyeva et al, 2009;Golyshkіn et al, 2015;Permyakova et al, 2016;Belemets et al, 2017). Taking into account that melanin doesn't elevate but reduces arginase activity, which was decreased in obese animals, it can be assumed that it cannot stimulate the ability of macrophages to polarize towards the pro-inflammatory phenotype that was suppressed in obesity.…”

Section: Discussionsupporting

confidence: 90%

“…Previously, melanin was observed to exhibit anti-inflammatory, antiulcer (Golyshkіn et al, 2015), antistress (Falalyeyeva et al, 2009) and antitumour properties (Permyakova et al, 2016). Yeast melanin prevents visceral fat accumulation in animals with glutamate-induced nonalcoholic liver disease, decreases the blood level of proinflammatory cytokine IL-1β and increases the level of anti-inflammatory cytokines IL-10, TGF-b (Belemets et al, 2017).…”

Section: Introductionmentioning

confidence: 97%

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Functional polarization of macrophages of rats with progesterone-induced obesity treated with melanin from the Antarctic yeast Nadsoniella nigra

Konopelnuk

Kompanets

Svyatetska

et al. 2019

Regul. Mech. Biosyst.

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Progesterone-induced obesity develops in women who use this drug for contraception and the menopause treatment, though its mechanisms remain poorly understood. We studied functional M1 and M2 polarizations of the abdominal cavity macrophages of rats with progesterone induced obesity during 28 days of administration. The effect of melanin from the Antarctic yeast Nadsoniella nigra (Chaetothyriales, Herpotrichiellaceae, Nadsoniella Issatsch, 1914) was investigated. The NO level was determined by the accumulation of nitrites, ROS level was estimated by the NBT-test, arginase activity was assayed by the reaction of L-arginine hydrolysis. The body weights of rats administrated progesterone increased by 27% and continued to increase one month after withdrawal of progesterone (55% higher than control). Melanin prevents the weight gain when administered during one month after progesterone withdrawal. The NO production by peritoneal macrophages of obese animals intensified by 31% indicating their polarization towards pro-inflammatory M1 type. Production of ROS did not change. A 14% increase in arginase activity was observed, indicating the inhibition of M2 (anti-inflammatory) polarization. In the progesterone withdrawal group all these rates significantly decreased, indicating a reduction in the functional activity of peritoneal macrophages’. Melanin decreased the NO and ROS production by 60% and 18% respectively in comparison with the progesterone group and unexpectedly reduced arginase activity. Our data provide evidence of the spread of inflammation in response to progesterone-induced obesity. Peritoneal macrophages are involved in the inflammation in obesity, undergoing polarization towards the pro-inflammatory phenotype. The long-term consequences of such inflammation include the continuation of weight gain and likely the development of systemic inflammation associated with the exhaustion of the functional capacity of peritoneal cavity macrophages. Melanin has an anti-obesity effect and exhibits anti-inflammatory properties preventing progesterone-induced weight gain and macrophage M1 polarization. This requires detailed elucidation and can be valuable in designing countermeasures to prevent obesity outcomes.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 97%

Functional polarization of macrophages of rats with progesterone-induced obesity treated with melanin from the Antarctic yeast Nadsoniella nigra

Konopelnuk

Kompanets

Svyatetska

et al. 2019

Regul. Mech. Biosyst.

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“…As a negatively charged brown macromolecule, A. auricular melanin (AAM) has higher edible safety and biological activity compared with chemical synthetic pigments [8]. More and more evidences show that natural melanin has a variety of biological activities, including protecting gastric mucosa [9], reducing liver fatty lesions [10], preventing oxidative stress [11], inhibiting the growth of colon cancer cells [12], anti-radiation [13], anti-adsorption of heavy metals [14]. It was previously reported that oral administration of AAM had an obvious hepatoprotective effect to alleviate alcoholic liver injury in mice [15].…”

Section: Introductionmentioning

confidence: 99%

Auricularia auricula Melanin Protects against Alcoholic Liver Injury and Modulates Intestinal Microbiota Composition in Mice Exposed to Alcohol Intake

Lin

Chen

Cao

et al. 2021

Foods

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The potential effects of Auricularia auricula melanin (AAM) on the intestinal flora and liver metabolome in mice exposed to alcohol intake were investigated for the first time. The results showed that oral administration of AAM significantly reduced the abnormal elevation of serum total triglyceride (TG), cholesterol (TC), low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and significantly inhibited hepatic lipid accumulation and steatosis in mice exposed to alcohol intake. Besides, the abnormally high levels of bile acids (BAs) and lactate dehydrogenase (LDH) in the liver of mice with alcohol intake were significantly decreased by AAM intervention, while the hepatic levels of glutathione (GSH) and superoxide dismutase (SOD) were appreciably increased. Compared with the model group, AAM supplementation significantly changed the composition of intestinal flora and up-regulated the levels of Akkermansia, Bifidobacterium, Romboutsia, Muribaculaceae, Lachnospiraceae_NK4A136_group, etc. Furthermore, liver metabolomics demonstrated that AAM had a significant regulatory effect on the composition of liver metabolites in mice with alcohol intake, especially the metabolites involved in phosphatidylinositol signaling system, ascorbate and aldarate metabolism, starch and sucrose metabolism, galactose metabolism, alpha-linolenic acid metabolism, glycolysis/gluconeogenesis, and biosynthesis of unsaturated fatty acids. At the gene level, AAM treatment regulated the mRNA levels of lipid metabolism and inflammatory response related genes in liver, including ACC-1, FASn, CPT-1, CD36, IFN-γ, LDLr and TNF-α. Conclusively, these findings suggest that AAM has potential beneficial effects on alleviating alcohol-induced liver injury and is expected to become a new functional food ingredient.

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Effects of polyphenol compounds melanin on NAFLD/NASH prevention

Belemets

Kobyliak

Virchenko

et al. 2017

Biomedicine & Pharmacotherapy

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The Influence of Melanin on the Gastric Mucosa and Hypothalamicpituitary-Adrenocortical Axis Under Acute Stress Conditions

Cited by 6 publications

References 10 publications

Functional polarization of macrophages of rats with progesterone-induced obesity treated with melanin from the Antarctic yeast Nadsoniella nigra

Functional polarization of macrophages of rats with progesterone-induced obesity treated with melanin from the Antarctic yeast Nadsoniella nigra

Auricularia auricula Melanin Protects against Alcoholic Liver Injury and Modulates Intestinal Microbiota Composition in Mice Exposed to Alcohol Intake

Effects of polyphenol compounds melanin on NAFLD/NASH prevention

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