The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability

Nesterkina, Mariia; Bilokon, Svitlana; Алєксєєва, Т. Г.; Chubyk, Inna; Kravchenko, Iryna

doi:10.1016/j.aspen.2018.06.004

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Як і проліферативний ріст, ендоредуплікація є досить чутливою до дії як генетичних, так і зовнішніх чинників [17]. Зокрема, у роботі [18] з'ясовано вплив на ендоредуплікацію та життєздатність плодових мушок монотерпеноїдів та похідних фенолу. Зокрема, пригнічувальну дію мало додавання евгенолу у культуральне середовище.…”

Section: результати та обговоренняunclassified

Reproduction and endoreduplication in Drosophila melanogaster Meig. when influenced by lead nitrate

Strashnyuk¹,

Taglina²

2020

Fakt. eksp. evol. org.

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Aim. The purpose of investigation was to study the reproductive ability and polyteny degree of chromosomes in Drosophila melanogaster Meig. under the influence of various concentrations of lead nitrate. Methods. Canton-S wild-type strain was used as the material. Flies developed on standard sugar-yeast medium, to which in the experiment lead nitrate was added in concentrations of 0.1, 1, and 10 mg/ml. The reproductive ability of the strain was evaluated by the number of adult offspring. The polyteny degree of chromosomes was studied on squashed preparations of larva salivary glands stained with acetoorsein by cytomorphometry. The preparations were obtained at late 3rd instar. Results. The number of adult offsprings decreased when lead nitrate was added to the nutrient medium: at a concentration of 0.1 mg/ml – by 22.8 %, at 1 mg/ml – by 38.9 %. A concentration of 10 mg/ml was lethal. Males showed greater sensitivity to the drug compared to females. The degree of polyteny of chromosomes in the salivary glands of larvae decreased on average by 5.0–6.5 %. Conclusions. Lead nitrate causes a significant, dose-dependent decrease in the reproductive ability of fruit flies and has a toxic effect on Drosophila cells, inhibiting the process of endoreduplication. Keywords: Drosophila melanogaster Meig., heavy metals, fecundity, giant chromosomes, polyteny.

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Section: результати та обговоренняunclassified

Reproduction and endoreduplication in Drosophila melanogaster Meig. when influenced by lead nitrate

Strashnyuk¹,

Taglina²

2020

Fakt. eksp. evol. org.

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“…Dietary supplementation of vitamins (Bahadorani, Bahadorani, Phillips, & Hilliker, 2008), blueberry (Senthilkumar et al, 2020), and apple phenols (Nesterkina, Bilokon, Alieksieieva, Chubyk, & Kravchenko, 2018) have been revealed to lengthen adult life span in flies. Nevertheless, why antioxidants have acted poorly in clinical trials might have to do with the reality that these compounds may only be efficient in a constricted temporal windowpane in relative to oxidative damage (Lananna & Musiek, 2020).…”

Section: Introductionmentioning

confidence: 99%

Hesperidin modulates the rhythmic proteomic profiling in Drosophila melanogaster under oxidative stress

Jayapalan

Subramanian

Kani

et al. 2020

Arch Insect Biochem Physiol

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The circadian clock regulates vital aspects of physiology including protein synthesis and oxidative stress response. In this investigation, we performed a proteome-wide scrutiny of rhythmic protein accrual in Drosophila melanogaster on exposure to rotenone, rotenone + hesperidin and hesperidin in D. melanogaster. Total protein from fly samples collected at 6 h intervals over the 24 h period was subjected to two-dimensional gel electrophoresis and mass spectrometry. Bioinformatics tool, Protein ANalysis THrough Evolutionary Relationships classification system was used to the determine the biological processes of the proteins of altered abundance. Conspicuous variations in the proteome (151 proteins) of the flies exposed to oxidative stress (by rotenone treatment) and after alleviating oxidative stress (by hesperidin treatment) were observed during the 24 h cycle. Significantly altered levels of abundance of a wide variety of proteins under oxidative stress (rotenone treatment) and under alleviation of oxidative stress (rotenone + hesperidin treatment) and hesperidin (alone) treatment were observed. These proteins are involved in metabolism, muscle activity, heat shock response, redox homeostasis, protein synthesis/folding/degradation, development, ion-channel/cellular transport, and gustatory and olfactory function of the flies. Our data indicates that

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“…An increase in endoreduplication was observed in D. melanogaster ovarian pseudonurse cells at low temperatures and protein-rich food (Mal`ceva et al 1995). In contrast, the depleted amino acid composition of the nutrient medium inhibited endoreduplication in the larval tissues of Drosophila(Britton and Edgar 1998) Nesterkina et al (2018Nesterkina et al ( , 2020. reported on the action of terpenoids and phenols, which are used in the development of modern insect pest control technologies, on the degree of chromosome polyteny Lei et al (2020).…”

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Variability of polyteny of giant chromosomes in Drosophila melanogaster salivary glands

2022

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Polyteny is an effective mechanism for accelerating growth and enhancing gene expression in eukaryotes. The purpose of investigation was to study the genetic variability of polyteny degree of giant chromosomes in the salivary glands of Drosophila melanogaster Meig. in relation to the differential tness of different genotypes. 16 strains, lines and hybrids of fruit ies were studied. This study demonstrates the signi cant in uence of hereditary factors on the level of polytenization of giant chromosomes in Drosophila. This is manifested in the differences between strains and lines, the effect of inbreeding, chromosome isogenization, hybridization, adaptively signi cant selection, sexual differences, and varying degrees of individual variability of a trait in different strains, lines, and hybrids. The effect size of the genotype on the degree of chromosome polyteny in Drosophila salivary glands was 45.3%, the effect size of sex was 9.5%. The data obtained allow us to conclude that the variations in the level of polyteny should be considered as a manifestation of the structural and functional polymorphism of giant chromosomes, which is an essential factor in the differential tness of ies and has a selective value.

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The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability

Cited by 7 publications

References 11 publications

Reproduction and endoreduplication in Drosophila melanogaster Meig. when influenced by lead nitrate

Reproduction and endoreduplication in Drosophila melanogaster Meig. when influenced by lead nitrate

Hesperidin modulates the rhythmic proteomic profiling in Drosophila melanogaster under oxidative stress

Variability of polyteny of giant chromosomes in Drosophila melanogaster salivary glands

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