The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome

Özgün, Mahmut Tuncay; Uludağ, Semih; Öner, Gökalp; Batukan, Cem; Aygen, Ercan; Şahin, Yılmaz

doi:10.3109/01443615.2010.546906

Cited by 32 publications

(44 citation statements)

References 44 publications

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“…Overweight is associated with several symptoms of PCOS including hirsutism, a clinical marker of elevated androgens, higher rates of oligo‐ and amenorrhoea, infertility and miscarriage compared with lean women . We found that AMH and AMHR‐II expression both PCOS and non‐PCOS women was negatively correlated with BMI.…”

Section: Discussionmentioning

confidence: 64%

“…17 Overweight is associated with several symptoms of PCOS including hirsutism, a clinical marker of elevated androgens, 18 higher rates of oligo-and amenorrhoea, infertility and miscarriage compared with lean women. 19 We found that AMH and AMHR-II expression both PCOS and non-PCOS women was negatively correlated with BMI. The observed inverse association between AMH, AMHR-II expression and BMI suggests that obesity-related hormonal dysfunction of adipose tissue is a factor leading to the reduction in ovarian reserve in both obese PCOS and non-PCOS women.…”

Section: Discussionmentioning

confidence: 66%

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Association between BMI and gene expression of anti‐Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome

Nouri¹,

Aghadavod

Khani³

et al. 2016

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 66%

Association between BMI and gene expression of anti‐Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome

Nouri¹,

Aghadavod

Khani³

et al. 2016

Clinical Endocrinology

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“…A cohort analysis on 1417 cycles with 487 patients indicated the number of oocytes retrieved was negatively correlated with BMI increasing and the dose of gonadotropin [14]. While high level of leptin inhibit FSH secretion in obese patients and suppress the secretion of estrogen from theca cells [42], obese PCOS women was found to be associated with reduced number of oocytes retrieved [43][44][45]. However, the relationship between obesity, PCOS and the outcomes of IVF/ICSI remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index on Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Among Polycystic Ovarian Syndrome Patients

Cui

Wang

et al. 2016

Cell Physiol Biochem

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Background: The aim of this study is to assess the effect of body mass index (BMI) on outcomes of in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) among polycystic ovarian syndrome (PCOS) and non-PCOS patients. Methods: This was a retrospective cohort study that was performed in the Second Hospital of Hebei Medical University. Patients who were under 35 years old were included in the study and were divided into four groups based on their BMI. The number of retrieved oocytes, implantation rate, clinical pregnancy rate, miscarriage rate and live births among PCOS and non-PCOS patients were compared between different BMIs. Results: IVF/ICSI pregnancies in obese PCOS women had a considerably higher risk of miscarriage and low rate of clinical pregnancy than in non-obese PCOS pregnancies. However, in non-PCOS patient, obesity significantly elevated miscarriage rate but did not affect clinical pregnancy rate. Conclusion: Obesity in PCOS patients led to poor outcomes of IVF/ICSI.

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“…Hirsutism, a clinical marker of elevated androgens, is also more severe in obese PCOS women (45). Obese PCOS patients also have higher rates of oligo-and amenorrhea, infertility, and miscarriage compared with lean women with the disorder (8,45,65). Additionally, between 50 and 70% of women with PCOS suffer from some degree of insulin insensitivity, and SI scores worsen with increasing body mass index (BMI) (21,28,43,62).…”

mentioning

confidence: 99%

Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys

McGee

Bishop

Pohl

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

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McGee WK, Bishop CV, Pohl CR, Chang RJ, Marshall JC, Pau FK, Stouffer RL, Cameron JL. Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306: E1292-E1304, 2014. First published April 15, 2014; doi:10.1152/ajpendo.00310.2013.-Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n ϭ 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to the reproductive axis [increased luteinizing hormone (LH) pulse frequency] at 5 yr, without remarkable changes in ovarian or metabolic features. To examine the combined effects of T and obesity, at 5.5 yr (human equivalent age: 17 yr), monkeys were placed on a high-calorie, high-fat diet typical of Western cultures [Western style diet (WSD)], which increased body fat from Ͻ2% (pre-WSD) to 15-19% (14 mo WSD). By 6 mo on WSD, LH pulse frequency in the controls increased to that of T-treated animals, whereas LH pulse amplitude decreased in both groups and remained low. The numbers of antral follicles present during the early follicular phase increased in both groups on the WSD, but maximal follicular size decreased by 50%. During the late follicular phase, T-treated females had greater numbers of small antral follicles than controls. T-treated monkeys also had lower progesterone during the luteal phase of the menstrual cycle. Although fasting insulin did not vary between groups, T-treated animals had decreased insulin sensitivity after 1 yr on WSD. Thus, while WSD consumption alone led to some features characteristic of PCOS, T ϩ WSD caused a more severe phenotype with regard to insulin insensitivity, increased numbers of antral follicles at midcycle, and decreased circulating luteal phase progesterone levels. testosterone; obesity; amenorrhea; insulin insensitivity; ovarian follicle POLYCYSTIC OVARY SYNDROME (PCOS) affects 4 -8% of reproductive-aged women (5, 48) and is characterized by hyperandrogenemia (HA), irregular menstrual cycles, and polycystic ovaries, in addition to rapid luteinizing hormone (LH) pulse frequency, increased LH response to gonadotropin-releasing hormone (GnRH), decreased sensitivity to progesterone (P 4 ) negative feedback, and decreased insulin sensitivity (SI) (13,20,90). Moreover, up to 90% of women with PCOS are overweight or obese, which is higher than the general population of the United States, where 65% of women over the age of 20 are overweight or obese (6, 33). Women with PCOS also tend to have a central distribution of adiposity, which is associated with increased rates of high blood pressure and cardiovascular disease (23, 51).Being overweight or obese aggravates many symptoms of PCOS. Basal production of testosterone (T) and free T are reportedly elevated in obese, compar...

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The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome

Cited by 32 publications

References 44 publications

Association between BMI and gene expression of anti‐Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome

Association between BMI and gene expression of anti‐Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome

Impact of Body Mass Index on Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Among Polycystic Ovarian Syndrome Patients

Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys

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