The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

Santos, Andrea; Azevedo, George Dantas de; Lemos, Telma Maria Araújo Moura

doi:10.21767/2172-0479.1000100

Cited by 9 publications

(14 citation statements)

References 24 publications

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“…Furthermore, in this study, the mean SOD activity for the test group was significantly lower than that of the control group. This finding is in agreement with some previous studies [2427], but not with certain other works [2025] that demonstrated significantly higher SOD activity in PCOS patients, when compared with control groups. The authors actually concluded that the elevations in SOD activity recorded in those studies might have been due to a compensatory response by the body's defense mechanisms to higher circulating levels of oxidants [25].…”

Section: Discussionsupporting

confidence: 92%

“…This particular finding has also been documented previously [20]. However; a number of other authors demonstrated significantly lower activity of GSH-Px among obese PCOS patients, when compared with other obese women without PCOS [27]. GSH-Px eliminates peroxides in biological systems by employing a reduced form of glutathione as a hydrogen ion donor [16].…”

Section: Discussionsupporting

confidence: 77%

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Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

et al. 2019

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ObjectiveTo determine the activities of oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome (PCOS) in Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.MethodsThis was a nested case-control study consisting of 50 PCOS patients and 50 healthy women of the same age range without any evidence of PCOS. The study measured the levels of malondialdehyde (MDA), activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC); concentrations of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C) using standard spectrophotometric methods. Anthropometric indices were also assessed. P-values of <0.05 were taken to be statistically significant.ResultsThere were significantly higher levels of MDA (P=0.002), lower activity of SOD (P<0.001), and lower TAC (P=0.001) in PCOS patients when compared with the controls. There were higher concentrations of TC (P=0.017) and LDL-C P=0.012) in PCOS patients than in controls. Significant differences were not observed between the 2 groups in terms of the activity of GSH-Px, as well as the concentrations of HDL-C and TG. The body mass index, waist circumference, and waist-hip ratio were all significantly higher in PCOS patients.ConclusionThis study revealed higher levels of MDA, as well as lower activity of SOD and TAC, among PCOS patients. Furthermore, there were higher levels of TC and LDL-C among the PCOS patients. Hence, monitoring these parameters may improve the clinical management of PCOS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 77%

Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

et al. 2019

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“…In the present study, significantly lower plasma catalase levels, a marker for antioxidant, demonstrate poor antioxidant status and higher MDA level, index of oxidant reflecting the prevalence of higher oxidative stress in PCOS agrees the observation of other studies done on PCOS patients 13,15,[26][27][28][29][30] . These result indicates presence of higher oxidative stress in the current series of PCOS patients.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, a number of clinical studies found increased oxidative stress in PCOS patients [13][14][15] . Several researchers also reported, increased oxidative stress contributes to increased risk of cardiovascular disease (CVD) in PCOS, which was related to their insulin resistance, hypertension, central obesity, and dyslipidemia 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Autonomic impairment and oxidative stress: Relationship in PCOS patients

Mostafa

Ferdousi

Sultana

et al. 2020

J Bangladesh Soc Physiol

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Background: Polycystic ovary syndrome (PCOS) is one of the most common, heterogeneous endocrine disorder of reproductive aged women. Association of autonomic impairment and elevated oxidative stress may predispose these patients to increased cardiovascular risks. Objective: To evaluate the relationship between cardiac autonomic nerve function (CANF) and oxidative stress in patients with PCOS. Methods: This cross sectional study was conducted in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from September, 2018 to August, 2019. For this study, 30 newly diagnosed PCOS patients aged 20-35 years were recruited and similar age, body mass index (BMI) 30 apparently healthy, regularly menstruating women were enrolled as control. CANF was assessed by analyzing time domain measures of Heart Rate Variability (HRV). HRV data were recorded by a digital data acquisition device, Powerlab 8/35 (AD instruments, Australia). For evaluation of oxidative stress, plasma catalase and plasma Malondialdehyde (MDA) levels were measured. Statistical analysis was done by unpaired “t” test and Pearson’s correlation test as applicable. Results: In this study, resting pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly higher (p<0.001, p<0.01, p<0.01 respectively) and standard deviation of the RR intervals (SDRR) (p<0.01), mean R-R interval, standard deviation of the difference between successive RR intervals (SDSD), square root of mean squared differences of successive RR intervals (RMSSD), proportion of RR interval with duration >50 ms (pRR50%) were significantly lower (p<0.001) in PCOS than healthy controls. In addition, plasma catalase was significantly lower (p<0.01) and plasma MDA was significantly higher (p<0.001) in PCOS patients compared to controls. On correlation analysis, mean heart rate, SDRR, SDSD, RMSSD and pRR50% showed negative correlation with plasma catalase and plasma MDA (p<0.05) in PCOS patients but these were not significant. Conclusion: The present study reveals that reduced parasympathetic activity in PCOS patients may be related to oxidative stress. J Bangladesh Soc Physiol. 2019, December; 14(2): 82-88

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“…Catalase is present in peroxisomes of all cells. It efficiently reduces H 2 O 2 to water and O 2 , thus protecting the body from its harmful effects of H 2 O 2 21 .Serum catalase level was found lower in PCOS compared to normal women in several studies [24][25][26] . olycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder associated with anovulatory P infertility affecting 8-13% of women worldwide 1 .…”

Section: Introductionmentioning

confidence: 99%

Relationship between parasympathetic reactivity and oxidative stress in Polycystic ovary syndrome

Akhter

Ferdousi

Sultana

et al. 2020

J Bangladesh Soc Physiol

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Background: Polycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder. Altered cardiovagal autonomic modulation and oxidative stress may predispose PCOS patients to increased cardiovascular morbidity. Objective: To assess the relationship between parasympathetic reactivity and oxidative stress in patients with PCOS. Methods: This crosssectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy women were also enrolled as control. Three noninvasive conventional autonomic function tests, such as heart rate response to deep breathing, standing and the Valsalva maneuver, were used for evaluation of parasympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level (oxidant) and plasma catalase level(antioxidant) were measured in all subjects by spectrophotometry. Data were expressed as mean± SD. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done as applicable. Results: In this study PCOS patients had significantly higher (p<0.01)resting heart rate, systolic and diastolic blood pressure than that of healthy control. But Expiration: Inspiration ratio, Expiration:Inspiration difference and 30:15 ratio during standing were significantly lower (p<0.001, p<0.01 and p<0.05 respectively) in PCOS compared to control. In addition, plasma catalase level was significantly lower (p<0.01)and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. Multiple regression analysis showed plasma catalase as a significant positive predictor (p<0.05) of the Valsalva ratio in PCOS. Also, Valsalva ratio showed significant negative association (p<0.05) with plasma malondialdehyde (p<0.01)in PCOS. Conclusion: Based on these results it is concluded that impaired parasympathetic reactivity showed inverse relationship with oxidative stress in PCOS. J Bangladesh Soc Physiol. 2019, December; 14(2): 48-55

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The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

Cited by 9 publications

References 24 publications

Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

Autonomic impairment and oxidative stress: Relationship in PCOS patients

Relationship between parasympathetic reactivity and oxidative stress in Polycystic ovary syndrome

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