The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components

Maslii, Yu. S.; Рубан, О. А.; Kasparavičienė, Giedrė; Kalvėnienė, Zenona; Ivanauskas, Liudas; Mazurkevičiūtė, Agnė; Kopustinskienė, Dalia M.; Bernatonienė, Jurga

doi:10.3390/molecules25215018

Cited by 42 publications

(28 citation statements)

References 33 publications

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“…Further, increasing pH is known to increase the viscosity of Carbopol gel. (47) The spreadability of all three hand sanitizer gel formulations increased with time. This is due to the drop in the viscosity of the tested formulations during storage.…”

Section: Discussionmentioning

confidence: 94%

Formulation and Characterization of Essential Oils Based Antibacterial Hand Sanitizer Gels

Diviyagahage¹,

Thuvaragan

et al. 2021

Pharm. J. SL

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Purpose:The usage of herbal-based antibacterial sanitizers is increasing, and they have considerably shown fewer side-effects than sanitizers with synthetic compounds. In the present study, essential oils obtained from cinnamon and lime were used to formulate hand sanitizer gels, and their efficacy was evaluated. Method: Three different hand sanitizer gel formulations were prepared using cinnamon oil (Formulation A), lime oil (Formulation B) and a mixture of cinnamon and lime oil (Formulation C). Carbopol 940 was used as the gelling agent. Tests for organoleptic, physicochemical characteristics and stability were conducted on the prepared formulations. The antibacterial activity of the prepared formulations was evaluated using the agar diffusion method. All three formulations were compared with a commercial liquid hand wash product for their in vitro antibacterial activity. Three-way ANOVA with Tukey's honestly significant difference test was used to compare the antibacterial activity of the hand sanitizer gel formulations. Stability of the three hand sanitizer formulations were assessed. Results: Considerable differences in the pH and viscosity were not observed between the prepared hand sanitizer gel formulations. However, considerable changes in the spreadability were observed between the prepared hand sanitizer gel formulations. A statistically significant difference in antibacterial activity was observed among the three hand sanitizer gels and the commercial hand wash (p<0.05). Formulation C showed the highest antibacterial activity among the prepared hand sanitizer formulations. Based on the stability studies, Formulation A was found to be the most stable. Conclusion: Hand sanitizer gel containing a mixture of cinnamon and lime oils showed the highest antibacterial activity among prepared formulations. However, the most stable formulation was the hand sanitizer gel containing cinnamon oil.

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Section: Discussionmentioning

confidence: 94%

Formulation and Characterization of Essential Oils Based Antibacterial Hand Sanitizer Gels

Diviyagahage¹,

Thuvaragan

et al. 2021

Pharm. J. SL

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“…Spreadability is an important characteristic to assess the spreading capabilities of the gel under the influence of facial muscle forces. The dosage form that is placed in between the buccal mucosa and the gingiva is pressed when the patient normally responds with facial expressions, speaking as well as ingesting reflexes [ 24 ]. Theoretically, there should be a definite value of spreadability so that the mucoadhesive surface area is exposed to mucosal tissue and the gel is not ingested during the former exercises of patient responses.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

et al. 2022

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Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that is converted to hydrocolloid gel in hot water with notable gel strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was to evaluate the mucoadhesive potential of AG binary dispersions in combination with Carbopol 934P (CP) as mucoadhesive gel preparations. The gels fabricated via homogenization were evaluated for ex vivo mucoadhesion, swelling index (SI), dissolution and stability studies. The mucoadhesive properties of AG were concentration dependent and it was improved by the addition of CP. Maximum mucoadhesive strength (MS) (27.03 g), mucoadhesive flow time (FT) (192.2 min), mucoadhesive time in volunteers (MT) (203.2 min) and SI (23.6% at 4 h) were observed with formulation F9. The mucoadhesive time investigated in volunteers (MT) was influenced by AG concentration and was greater than corresponding FT values. Formulations containing 0.3%, w/v AG (F3 and F9) were able to sustain the release (~99%) for both drugs till 3 h. The optimized formulation (F9) did not evoke any inflammation, irritation or pain in the buccal cavity of healthy volunteers and was also stable up to 6 months. Therefore, AG could be considered a natural and potential polymer with profound mucoadhesive properties to deliver drugs through the mucosal route.

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“…An Erweka SSP tester (ERWEKA GmbH, Germany) was used as device. The determination was performed according to the method 2.2.15 "Melting point -open tube capillary method" SPhU [22]. The sample considered to have passed the test if the melting point was ≤ 37.2 ° C.…”

Section: Research Of Technological Parameters Of Suppository Samplesmentioning

confidence: 99%

Comprehensive study for the development of rectal suppositories with diosmin and hesperidin

Борко

Kovalevska

Grudko

et al. 2022

SR: PS

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The aim. To conduct a comprehensive study of biphasic-type suppositories that contain diosmin and hesperidin. Materials and methods. Samples of biphasic-type suppositories with a mass of 4.0 were objects of the study. Pharmacological, technological and analytical research methods were used to directly or indirectly analyze the strength and completeness of the drug activity. Thus, in this work we combined the study of the specificity of the pharmacological action of the drug, experimental verification of the quantitative content of API, analysis of the structural properties of suppositories and study of the profile of the release of active pharmaceutical ingredients. Results. Therefore, based on the obtained data, the most effective dose was 75 mg / kg (in terms of a human dose of 300 mg per suppository). The drug in the selected dose showed a significant therapeutic effect, which significantly exceeded that of the test sample at a lower dose and the reference agent. According to the results of technological studies, it was determined that all samples of suppositories had satisfactory structural and mechanical properties. Studies of the histological structure of the mucous membrane of rats proved that there is a positive effect of treatment with suppositories with diosmin and hesperidin due to the improvement of the normal condition of the mucous membrane, the absence of edema and ulcerative defect. Research of the release profile of active pharmaceutical ingredients showed that the best percentage of release is characteristic of sample 2 (99.8 %) Conclusions. Therefore, suppositories with diosmin and hesperidin in therapeutically dose of 75 mg/kg of animal weight can be used for further research and will be of interest in the treatment of hemorrhoids of both acute and chronic forms

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The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components

Cited by 42 publications

References 33 publications

Formulation and Characterization of Essential Oils Based Antibacterial Hand Sanitizer Gels

Formulation and Characterization of Essential Oils Based Antibacterial Hand Sanitizer Gels

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

Comprehensive study for the development of rectal suppositories with diosmin and hesperidin

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