The Influence of Plum (Prunus salicina Lindl) Extract to Liver MDA Levels in Rats Induced by High Fat Diet

Abstract

This observation was performed to evaluate the effect of Plum extract on liver damage with indicators of MDA levels in male rats. The goal of this study was to obtain the benefits of herbal elements such as hepatoprotection in rats induced by an excessive-fat diet. A high-fat diet is expected to produce a state of fatty liver with the aid of increasing the liver MDA. This study is a laboratory observation with a very randomized design, the use of 25 samples which had been grouped into five organizations which includes five rats, which are a negative group, a positive group, and three treatment groups who were given ethanol extract of plum dose of 0,8 mg/kg BW/day, 1,6 mg/kg BW/day and 2,4 mg/kg BW/day. The negative group was only given standard pellets while the positive group were given a high-fat diet and induced by propylthiouracil. The indicator that will be assessed is the liver MDA. The data obtained were analyzed using analysis of variance (ANOVA) and further tests were carried out with Duncan's test. The consequences confirmed that the liver MDA levels in the group given Plum fruit extract at doses of 0.8 mg/kg BW and 1.6 mg/kg BW were significantly lower than the positive control group. Plum fruit extract was able to inhibit the increase in liver MDA levels at an effective dose of 0.8 mg/kg BW.