The influence of polymorphonuclear leukocytes and macrophages on the growth of lymphocytes and fibroblasts in vitro

Polymorphonuclear Leukocyte Lysosome Activities and Lymphocyte Transformation in Multiple Sclerosis and some other Central Nervous System Chronic Diseases

“…Temporary decrease of lymphocyte transformation was ob served within a week of the tuberculin skin test [36], The new autosen sitization stimulus might have caused analogical reactions in MS patients. The unknown pathogenic factors have induced the PMNL lysosomal pro teins mitogenic potency which enhanced the lymphocyte proliferation [34], It is possible that PMNL lysosome mitogenic proteins influenced, like PHA [27], the immune response in vivo. The increase of mitogenic potency of PMNL lysosomes was observed in apoplexy; this central nerv ous system lesion may induce the autoimmune phenomena.…”

“…Increased awareness of the im portance of PMNL lysosomes in the pathogenesis of human diseases has prompted us to their study in some lesions of the central nervous system. The PMNL lysosome proteins contain not only the tissue-destructing en zymes but the lymphocyte and fibroblast-stimulating factors as well [32,34,35]. The possibility of an immunological basis for MS gains some support from lymphocyte reactivity studies in vitro, although there is some controversy as to whether there are any changes in lymphocyte re sponsiveness to PHA or to the suspected autoantigen [12,37].…”