The influence of postoperative infection in survival of patients with high-grade gliomas

Alexiou, George Α.; Kallinteri, Amalia; Michos, Euaggelos; Zagorianakou, Panagiota; Priavali, Efthalia; Pachatouridis, Dimitrios; Levidiotou, S.; Voulgaris, Spyridon

doi:10.4103/2347-8659.149418

Cited by 7 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence from the literature to date is sparse and does not provide a clear conclusion on whether or not the postoperative infection affects survival in patients with HGG (7,8). However, several case reports have been published of patients with a local wound infection after HGG resection and long-term survival (7,(9)(10)(11). Below, we discuss two cases of patients with long-term survival after treatment for GBM, IDH-wildtype, WHO grade IV (diseasefree survival of 61 months after the second resection of first GBM recurrence), and AA, IDH-mutant, WHO grade III (OS 152 months) both cases were reclassified based on the WHO classification 2016 (2).…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

et al. 2022

View full text Add to dashboard Cite

High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The most common organisms in the studies by Salle et (23). While the largest clinical study on topic didn't report the type of infections involved (21), another series reported survival benefit after infection with a Gram negative organism, Enterobacter (Klebsiella) aerogenes (24).…”

Section: Methodological Constraints In Available Clinical Literaturementioning

confidence: 99%

“…In a case series, Alexiou et al reported a survival time of 42 months in a GBM patient with postoperative bacterial infection, with an institutional median survival of 15.5 months (23). Another GBM patient in the same series with postoperative bacterial infection had an overall survival time of 14 years (168 months) (23).…”

Section: Clinical Studies On the Potential Role Of Postoperative Bacterial Infection On Survival In Gbm Patientsmentioning

confidence: 99%

See 1 more Smart Citation

The Survival Benefit of Postoperative Bacterial Infections in Patients With Glioblastoma Multiforme: Myth or Reality?

et al. 2021

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM), the most common malignant brain tumor, universally carries a poor prognosis. Despite aggressive multimodality treatment, the median survival is ~18–20 months, depending on molecular subgroups. A long history of observations suggests antitumor effects of bacterial infections against malignant tumors. The present review summarizes and critically analyzes the clinical data providing evidence for or against the survival benefit of post-operative bacterial infections in GBM patients. Furthermore, we explore the probable underlying mechanism(s) from basic science studies on the topic. There are plausible explanations from immunobiology for the mechanism of the “favorable effect” of bacterial infections in GBM patients. However, available clinical literature does not provide a definitive association between postoperative bacterial infection and prolonged survival in GBM patients. The presently available, single-/multi-center and national database retrospective case-control studies on the topic provide conflicting results. A prospective randomized study on the subject is clearly not possible. Immunobiology literature supports development of genetically modified bacteria as part of multimodal regimen against GBM.

show abstract

“…[5] GBM cases of increased survival after bacterial infection have been documented, whereas patients with neutrophil to lymphocyte ratio in the blood that exceeded 4.7 differ significantly from those with neutrophil to lymphocyte ratio lower than 4.7 and were associated with worse survival. [6,7] Nevertheless, GBM can evade by several mechanisms immune surveillance, such as loss of major histocompatibility complex (MHC) antigen expression that prevent their recognition by the CD8 + T cells. [8] CD8 + T cell cytotoxic activity has been considered key for tumor eradication and these cells have been detected in GBM tissue.…”

Section: Introductionmentioning

confidence: 99%

Immunotherapeutic strategies for glioma treatment

Alexiou¹,

Kyritsis²

2016

View full text Add to dashboard Cite

Glioblastoma is the most common and malignant primary brain tumor. Despite intensive clinical investigation and several novel therapeutic approaches, the median survival continues to remain poor and it is usually in the range of fifteen months. Immunotherapy is a beacon of hope for cancer treatment and offers a different approach against glioma. Various approaches have been used, such as dendritic cell based vaccines, peptide vaccines, T-cell-based therapies and immune checkpoint blockade with promising results. This paper provided an overview of the results of the most exciting immune therapeutic strategies for the treatment of gliomas.

show abstract

The influence of postoperative infection in survival of patients with high-grade gliomas

Cited by 7 publications

References 0 publications

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

The Survival Benefit of Postoperative Bacterial Infections in Patients With Glioblastoma Multiforme: Myth or Reality?

Immunotherapeutic strategies for glioma treatment

Contact Info

Product

Resources

About