The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns

Hu, Hao; Gu, Xia; Cai, Yujun; Xiong, Hui; Huang, Liping; Shen, Wei; Ma, Fei; Xiao, Xueshan; Li, Sitao

doi:10.21037/tp-20-211

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…It is not only used for disease diagnosis and prognosis assessments, but also serves as an important means of exploring new therapeutic approaches for diseases (6). Among the plethora of metabolomics research methodologies, tandem mass spectrometry (MS/MS) is a fundamental technique that has been extensively utilized in the investigation of newborns and the treatment of inherited metabolic diseases (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies

Cai,

Deng,

Yang

et al. 2024

Front. Immunol.

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IntroductionPregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear.MethodsIn this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants.ResultsWe found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE.DiscussionBy constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE.

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Section: Introductionmentioning

confidence: 99%

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies

Cai,

Deng,

Yang

et al. 2024

Front. Immunol.

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Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios

Yang,

Song,

Deng

et al. 2023

Eur J Pediatr

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Application value of analgesia throughout labor and analgesia during the first stage of labor in women with pregnancy-induced hypertension

Yang

Yan

et al. 2023

THC

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BACKGROUND: Effective analgesia is required to ensure maternal and neonatal safety. OBJECTIVE: To compare the therapeutic effects of analgesia applied throughout labor and analgesia applied during the first stage of labor in women with pregnancy-induced hypertension (PIH). METHODS: In this study, 120 puerperae with PIH who gave birth in our hospital were enrolled as the study participants and were randomized into two groups (n= 60 in each group) using a coin flip. Those who received analgesia throughout labor were enrolled in the observation group, and those administered analgesia during the first stage of labor were enrolled in the control group. The analgesic effects, changes in blood pressure during labor, and neonatal health were compared between the two groups. RESULTS: Differences in visual analog scale (VAS) scores before analgesia, 10 min after analgesia, and full cervical dilation between the two groups were not statistically significant (P> 0.05 in all). The VAS scores of the puerperae in the observation group during forced breathing in the second stage of labor and fetal head expulsion were lower than those in the control group (P< 0.05 for both). The incidence of postpartum hemorrhage, forceps delivery, and antihypertensive treatment in the observation group was slightly lower than in the control group, but the differences were not statistically significant (P> 0.05). The rate of oxytocin treatment in puerperae in the observation group was significantly lower than in the control group (P< 0.05). The differences in base excess, arterial partial pressure of oxygen, partial pressure of carbon dioxide, and pH between the two groups of newborns were not statistically significant (P> 0.05 for all). Differences in changes in systolic and diastolic blood pressure between the two groups of puerperae were not statistically significant (P> 0.05 for both). Eclampsia did not occur during labor in either group. CONCLUSION: For patients with PIH, the application of analgesia throughout labor had a positive analgesic effect, effectively controlling the changes in blood pressure and ensuring the health of newborns. This is worthy of widespread clinical application.

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The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns

Cited by 3 publications

References 22 publications

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies

Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios

Application value of analgesia throughout labor and analgesia during the first stage of labor in women with pregnancy-induced hypertension

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