The influence of recombinant human BMP-2 on bone–implant osseointegration: biomechanical testing and histomorphometric analysis

Lan, Jing; Wang, Z.F.; Shu, Bin; Xia, Haibin; Cheng, Xiang‐Rong

doi:10.1016/j.ijom.2006.10.019

Cited by 34 publications

(32 citation statements)

References 18 publications

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“…Further studies are necessary to investigate the early events of bone formation around the metallic surface implants upon the implant is placed. It has been suggested by mechanical testing that bone thickness may improve osseointegration and anchoring of implants (Branemark 1983; Lan et al 2007; Xiao et al 2011). In this context we think that biomechanical tests, such as pull-out test, would provide more information about the stability of the interface between the implant surface and the new bone.…”

Section: Discussionmentioning

confidence: 99%

Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

et al. 2014

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The mechanical properties and good biocompatibility of zirconium and some of its alloys make these materials good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, the surface of pure zirconium modified by anodisation in acidic media at low potentials to enhance its barrier protection given by the oxides and osseointegration. Bare, commercially pure zirconium cylinders were compared to samples anodised at 30 V through electrochemical tests and scanning electron microscopy (SEM). For both conditions, in vivo tests were performed in a rat tibial osteotomy model. The histological features and fluorochrome-labelling changes of newly bone formed around the implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical tests and SEM images show that the anodisation treatment increases the barrier effect over the material and the in vivo tests show continuous newly formed bone around the implant with a different amount of osteocytes in their lacunae depending on the region. There was no significant change in bone thickness around either kind of implant but the anodised samples had a significantly higher mineral apposition, suggesting that the anodisation treatment stimulates and assists the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model, making zirconium a strong candidate material for permanent implants.

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Section: Discussionmentioning

confidence: 99%

Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

et al. 2014

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“…BMP-A: non-covalently immobilized rhBMP-2 (596 ng/cm 2 )4. BMP-B: covalently immobilized rhBMP-2 (819 ng/cm 2 )4 weeksBIC and BD: BMP-B > BMP-A > CSA > CLan et al [25]Rabbit - femur1. A: with rhBMP-22.…”

Section: Resultsmentioning

confidence: 99%

Dental implant bioactive surface modifications and their effects on osseointegration: a review

Meng¹,

Chien

2016

Biomark Res

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BackgroundThe purpose of this article is to review and update the current developments of biologically active dental implant surfaces and their effect on osseointegration.MethodsPubMed was searched for entries from January 2006 to January 2016. Only in-vivo studies that evaluated the effects of biomolecular coatings on titanium dental implants inserted into the bone of animals or humans were included.ResultsThirty four non-review studies provided data and observations were included in this review. Within the criteria, four categories of biomolecular coatings were evaluated. The potential biomolecules include bone morphogenetic proteins in 8 articles, other growth factors in 8 articles, peptides in 5 articles, and extracellular matrix in 13 articles. Most articles had a healing period of 1 to 3 months and the longest time of study was 6 months. In addition, all studies comprised of implants inserted in animals except for one, which evaluated implants placed in both animals and humans. The results indicate that dental implant surface modification with biological molecules seem to improve performance as demonstrated by histomorphometric analysis (such as percentage of bone-to-implant contact and peri-implant bone density) and biomechanical testing (such as removal torque, push-out/pull-out tests, and resonance frequency analysis).ConclusionsBioactive surface modifications on implant surfaces do not always offer a beneficial effect on osseointegration. Nevertheless, surface modifications of titanium dental implants with biomolecular coatings seem to promote peri-implant bone formation, resulting in enhanced osseointegration during the early stages of healing. However, long-term clinical studies are needed to validate this result. In addition, clinicians must keep in mind that results from animal experiments need not necessarily reflect the human clinical reality.

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“…In this study, rhBMP-2 was selected because its production process is simple, and the production cycle is short 3,8,16,18,19 . Simple BMP can be diluted easily or degraded in vivo and it will barely induce osteogenesis; hence, it is important to find a suitable scaffold material as a carrier 1,2,[4][5][6]9,15 .…”

Section: Discussionmentioning

confidence: 99%

Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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The influence of recombinant human BMP-2 on bone–implant osseointegration: biomechanical testing and histomorphometric analysis

Cited by 34 publications

References 18 publications

Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

Dental implant bioactive surface modifications and their effects on osseointegration: a review

Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology

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